4-BROMO-3-CHLOROANILINE
- Product Name
- 4-BROMO-3-CHLOROANILINE
- CAS No.
- 21402-26-6
- Chemical Name
- 4-BROMO-3-CHLOROANILINE
- Synonyms
- AKOS 90302;4-Bromo-3-chlo;EINECS 244-370-3;4-Brom-3-chloranilin;Chloro-4-bromoaniline;4-BROMO-3-CHLOROANILINE;3-Chloro-4-Bromoaniline;4-Bromo-3-chloroaniline,96%;4-Bromo-3-chlorobenzenamine;4-Bromo-3-chloroaniline >
- CBNumber
- CB9382316
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 21402-26-6.mol
4-BROMO-3-CHLOROANILINE Property
- Melting point:
- 74 °C
- Boiling point:
- 276.3±20.0 °C(Predicted)
- Density
- 1.722±0.06 g/cm3(Predicted)
- Flash point:
- >100 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.84±0.10(Predicted)
- color
- White to Light yellow
- BRN
- 1210160
- InChI
- InChI=1S/C6H5BrClN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
- InChIKey
- QLYHPNUFNZJXOQ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Br)C(Cl)=C1
- CAS DataBase Reference
- 21402-26-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 20/21/22-33-36/37/38-22
- Safety Statements
- 28-36/37-36/37/39-26-23
- RIDADR
- 2811
- Hazard Note
- Harmful
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B3709
- Product name
- 4-Bromo-3-chloroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- B3709
- Product name
- 4-Bromo-3-chloroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $361
- Updated
- 2025/07/31
- Product number
- B685443
- Product name
- 4-Bromo-3-chloroaniline
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 003693
- Product name
- 4-Bromo-3-chloroaniline
- Purity
- 99%
- Packaging
- 100g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 133050
- Product name
- 4-Bromo-3-chloroaniline
- Purity
- 97%
- Packaging
- 100g
- Price
- $120
- Updated
- 2021/12/16
4-BROMO-3-CHLOROANILINE Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
4-Bromo-3-chloroaniline is a precursor or building block in medicine, pesticide and dyestuffs.
Synthesis
108-42-9
21402-26-6
General method: A solution was prepared by dissolving m-chloroaniline (2a or 2b) in DMF as starting material. Subsequently, another solution was prepared by dissolving NBS (92 mmol, 1.0 eq.) in 100 ml DMF. The DMF solution of m-chloroaniline was added dropwise to the DMF solution of NBS at room temperature. After the dropwise addition, the reaction mixture was stirred continuously for 3 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with 500 ml of ethyl acetate and washed with 2 x 150 ml of brine. The organic phase was separated, dried with anhydrous Na2SO4, filtered and concentrated to give 4-bromo-3-chloroaniline (3a or 3b) as a brown solid in 90-92% yield. In another experiment, m-chloroaniline (2a or 2b, 0.8 mmol) was dissolved in a solvent of choice (1 ml) and a solution of NBS (0.8 mmol) in the same solvent (1 ml) was added in batches at room temperature. The reaction progression was monitored by LC-MS/MS and a final mixture containing traces of the dibrominated product was obtained.
References
[1] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 539 - 552
[2] Patent: CN107089919, 2017, A. Location in patent: Paragraph 0044; 0045; 0046; 0047
[3] Synthetic Communications, 2009, vol. 39, # 10, p. 1817 - 1824
4-BROMO-3-CHLOROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-3-CHLOROANILINE Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from 4-BROMO-3-CHLOROANILINE manufacturers
- Product
- 4-BROMO-3-CHLOROANILINE 21402-26-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-26
- Product
- 4-Bromo-3-chloroaniline 21402-26-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 4-BROMO-3-CHLOROANILINE 21402-26-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-05