D(+)-Galactosamine hydrochloride

Product Name: D(+)-Galactosamine hydrochloride
CAS No.: 1772-03-8
Chemical Name: D(+)-Galactosamine hydrochloride
Synonyms: Galactosamine;D-GALACTOSAMINE HYDROCHLORIDE;GALACTOSAMINE HCL;D-GALACTOSAMINE HCL;GALACTOSAMINE HYDROCHLORIDE;2-Amino-2-Deoxy-D-Galactopyranose;D-GALN HCL;CHONDROSAMINE;D-GalactosaMine HC1;actosamine hydrochL
CBNumber: CB9386354
Molecular Formula: C6H14ClNO5
Formula Weight: 215.63
MOL File: 1772-03-8.mol

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D(+)-Galactosamine hydrochloride Property

Melting point:: 182-185 °C (dec.)(lit.)
alpha: 96 º (589nm c=1,H2O,24 hrs)
Density: 1.3965 (rough estimate)
refractive index: 96 ° (C=1, H2O)
storage temp.: room temp
solubility: H₂O: 50 mg/mL, clear, colorless
form: White solid
color: White to Off-White
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
Merck: 14,4334
BRN: 3697825
Stability:: Moisture Sensitive
CAS DataBase Reference: 1772-03-8(CAS DataBase Reference)
EPA Substance Registry System: D-Galactose, 2-amino-2-deoxy-, hydrochloride (1772-03-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26
WGK Germany: 3
RTECS: LW5500000
F: 3-10
TSCA: Yes
HS Code: 29329970

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34539-M
Product name: D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem
Packaging: 34539-1GM
Price: $92.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1287722
Product name: Galactosamine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $536
Updated: 2024/03/01

Sigma-Aldrich

Product number: 34539-M
Product name: D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem
Packaging: 1G
Price: $71.7
Updated: 2022/05/15

Alfa Aesar

Product number: L07462
Product name: D-Galactosamine hydrochloride, 98%
Packaging: 250mg
Price: $23.8
Updated: 2021/12/16

Alfa Aesar

Product number: L07462
Product name: D-Galactosamine hydrochloride, 98%
Packaging: 1g
Price: $79.2
Updated: 2021/12/16

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D(+)-Galactosamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

D-(+)-Galactosamine (D-chondrosamine) is used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.

Uses

D-(+)-Galactosamine hydrochloride has been used to:

induce livery injury
inflammatory liver injury
acute liver failure (ALF) in mice

Uses

Specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Synthesis

A preparation process of D-galactosamine hydrochloride, adding 500ml absolute ethanol into a 1000ml three-necked flask with a reflux condenser, a stirrer and a thermometer, stirring at room temperature and adding 100g of dimethyl dodecyl respectively Tetradecylamine and 500g of solid-supported silica were heated to 110°C within 30 minutes, kept in reflux for 5 hours and then lowered to 29°C, filtered and dried to obtain 589g of organic amine solid-supported catalyst. In a 1000ml three-necked flask with a stirrer and a thermometer, 190g of 5-methyltryptamine hydrochloride and 600ml of dimethylamide were respectively added, 59g of organic amine solid-supported catalyst and 150g of chloropropene were added, and the reaction was carried out for eight hours at room temperature. Liquid filtration, the obtained filtrate was evaporated to dryness and dissolved in 1150ml of isopropanol, and 89ml of 36wt% hydrochloric acid was added to hydrochloride to obtain 130.32g of white crystals of 2-amino-2-deoxy-D-galactose hydrochloride with a yield of 42.05%.

Purification Methods

Dissolve the hydrochloride in a small volume of H2O. Then add three volumes of EtOH, followed by acetone until faintly turbid and keep overnight in a refrigerator. [Roseman & Ludoweig J Am Chem Soc 76 301 1954, Beilstein 4 IV 2024.]

D(+)-Galactosamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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D(+)-Galactosamine hydrochloride Suppliers

Belgium 1 Canada 2 China 381 Czech Republic 1 Europe 4 France 2 Germany 7 India 13 Japan 5 New Zealand 1 South Korea 1 Switzerland 4 United Kingdom 15 United States 50 Global 487

TCI Chemicals (India) Pvt. Ltd.

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Triveni chemicals

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Alfa Aesar

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Sisco Research Laboratories Pvt. Ltd.

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Central Drug House(P) Ltd.

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A.J Chemicals

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CHEMSWORTH

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ProdList: 6700
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View Lastest Price from D(+)-Galactosamine hydrochloride manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: D(+)-Galactosamine hydrochloride 1772-03-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000
Release date: 2023-08-11

Hebei Weibang Biotechnology Co., Ltd

Product: D(+)-Galactosamine hydrochloride 1772-03-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: D(+)-Galactosamine hydrochloride 1772-03-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-14

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