ChemicalBook > CAS DataBase List > 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE

5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE

Product Name
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
CAS No.
57489-77-7
Chemical Name
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Synonyms
oropyrazoL;o[1,5-a]pyrimidine;7-dichloropyrazolo[1;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE CAS 57489-77-7
CBNumber
CB9387447
Molecular Formula
C6H3Cl2N3
Formula Weight
188.01
MOL File
57489-77-7.mol
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property

Melting point:
68-71 °C(Solv: ethanol (64-17-5))
Density 
1.69±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-1.68±0.30(Predicted)
InChI
InChI=1S/C6H3Cl2N3/c7-4-3-5(8)11-6(10-4)1-2-9-11/h1-3H
InChIKey
JMTFWCYVZOFHLR-UHFFFAOYSA-N
SMILES
C12=CC=NN1C(Cl)=CC(Cl)=N2
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D438268
Product name
5,7-Dichloropyrazolo[1,5-A]pyrimidine
Packaging
10mg
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
CAPOD13936
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD143003
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
250mg
Price
$57.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD143003
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
500mg
Price
$100
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-HL
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
1g
Price
$109
Updated
2021/12/16
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

5,7-Dichloropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate compound that can be used in a palladium-catalysed pharmaceutical synthesis cross-coupling reaction. 2,4-Dichloroquinoline reacts with benzylzinc and phenylzinc reagents in the presence of catalytic quantities of palladium complexes to yield only α-substituted products.2,4-Dichloroquinolines have been found to react with benzylzinc and phenylzinc reagents in catalytic amounts of palladium compounds to produce only α-substituted products. LiCl was found to be an effective additive for γ-selective coupling reactions. These α- or γ-selective coupling conditions are applicable to the reaction of 5,7-Dichloropyrazolo[1,5-a]pyrimidine and biphenylmethyl zinc reagents in the synthesis of angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other α,γ-dichloropyrazine systems[1].

References

[1] TAKESHI SHIOTA; Teruo Y. Regioselective Reactions of Organozinc Reagents with 2,4-Dichloroquinoline and 5,7-Dichloropyrazolo[1,5-a]pyrimidine[J]. ACS Applied Electronic Materials, 1999. DOI:10.1021/jo981423a.

5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Suppliers

China 194 China Hong Kong 1 Germany 2 India 5 United Kingdom 3 United States 21 Global 226
Pure Chemistry Scientific Inc.
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View Lastest Price from 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5,7-dichloropyrazolo[1,5-a]pyrimidine 57489-77-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 57489-77-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

57489-77-7, 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINERelated Search:

5,7-dichloroiMidazo[1,2-c]pyriMidine Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5,7-dichloro-, ethyl ester 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-3-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-3-ETHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 2-(4-BROMOPHENYL)-5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-FLUOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE

  • 7-dichloropyrazolo[1
  • 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
  • Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-
  • o[1,5-a]pyrimidine
  • oropyrazoL
  • 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE CAS 57489-77-7
  • 57489-77-7
  • Heterocycle-Pyrimidine series
  • CHIRAL CHEMICALS