ChemicalBook > CAS DataBase List > Dinoprost tromethamine

Dinoprost tromethamine

Product Name
Dinoprost tromethamine
CAS No.
38562-01-5
Chemical Name
Dinoprost tromethamine
Synonyms
583e;u14585;lutalyse;PGF2αTris;Ensaprost;u-14,583e;PGF2ALPHA;Zinoprost;PGF2a-THAM;THAM PGF2α
CBNumber
CB9394313
Molecular Formula
C24H45NO8
Formula Weight
475.62
MOL File
38562-01-5.mol
More
Less

Dinoprost tromethamine Property

Melting point:
100-101°
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
form 
powder
color 
white
Merck 
13,7970
BRN 
4087514
Stability:
Hygroscopic
InChIKey
IYGXEHDCSOYNKY-RZHHZEQLSA-N
More
Less

Safety

Hazard Codes 
T
Risk Statements 
60-22
Safety Statements 
53-45
WGK Germany 
3
RTECS 
UK8025000
F 
8-10
HS Code 
2937500000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0424
Product name
Prostaglandin F2α tris salt
Purity
≥99%, synthetic, powder
Packaging
1mg
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
1213001
Product name
Dinoprost tromethamine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1396
Updated
2024/03/01
Alfa Aesar
Product number
J67245
Product name
Prostaglandin F2alpha tris salt, 99%
Packaging
1mg
Price
$69.9
Updated
2023/06/20
Alfa Aesar
Product number
J67245
Product name
Prostaglandin F2alpha tris salt, 99%
Packaging
5mg
Price
$283
Updated
2023/06/20
Cayman Chemical
Product number
16020
Product name
Prostaglandin F2α (tromethamine salt)
Purity
≥99%
Packaging
1mg
Price
$33
Updated
2024/03/01
More
Less

Dinoprost tromethamine Chemical Properties,Usage,Production

Description

Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.

Chemical Properties

White Solid

Originator

Prostin F2A,Upjohn,UK,1972

Uses

One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.

Indications

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

Definition

dinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.

Manufacturing Process

A solution of tris(hydroxymethyl)aminomethane (1.645 grams) in 3.0 ml of water at 60°C is added with vigorous stirring to a solution of PGF2α, (5.00 grams) in 700 ml of acetonitrile which has just been
ought to its boiling point. The vessel which contained the aqueous amine solution is rinsed with three 0.66 ml portions of water, each rinsing being added with vigorous stirring to the acetonitrile solution. The mixture is then cooled to 25°C by immersion of the vessel in cool water. At the cloud point, the vessel wall (glass) below the liquid surface is scratched vigorously with a glass rod. The mixture is then maintained at 25°C for 24 hours.
The resulting crystals are collected by filtration under nitrogen, washed on the filter with 50 ml of acetonitrile, and then dried by passing nitrogen at 50°C through the filter cake for one hour. Drying is completed in an oven at 70°C for 8 hours to give 5.965 grams of the tris(hydroxymethyl)aminomethane salt of PGF2α in free flowing crystalline form; MP 100°-101°C.

brand name

Prostin F2 Alpha (Pharmacia & Upjohn).

Therapeutic Function

Smooth muscle stimulant

Biochem/physiol Actions

Prostaglandin F2α is induced by uterine-produced oxytocin and acts on the corpus luteum to cause luteolysis and inhibit progesterone production.

Safety Profile

Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also other prostaglandin entries.

storage

Store at -20°C

Dinoprost tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Dinoprost tromethamine Suppliers

Belgium 1 Brazil 1 Canada 3 China 179 Europe 2 France 2 Germany 5 India 5 Poland 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 47 Global 261
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Pfizer CentreOne
Tel
--
Fax
--
Email
pfizercentreone@pfizer.com
Country
United States
ProdList
14
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
Byron Chemical Company, Inc
Tel
--
Fax
--
Email
bcc@byronchemical.com
Country
United States
ProdList
88
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
Parchem Fine & Specialty Chemicals
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
1031
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
eNovation Chemicals LLC
Tel
--
Fax
--
Email
ales@eNovationChem.com
Country
United States
ProdList
1673
Advantage
58
Advanced Compounds International. (ACI)
Tel
--
Fax
--
Email
info@advancedcompounds.com
Country
United States
ProdList
74
Advantage
58
Genegobio Inc.
Tel
--
Fax
--
Email
mark@genegobio.com
Country
United States
ProdList
195
Advantage
0
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
PHARMACIA AND UPJOHN CO LLC WHOLLY OWNED SUB OF PFIZER INC
Tel
--
Fax
--
Country
United States
ProdList
19
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Tecoland Corporation
Tel
--
Fax
--
Email
info@tecoland.com
Country
United States
ProdList
275
Advantage
50
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
More
Less

View Lastest Price from Dinoprost tromethamine manufacturers

Sinoway Industrial co., ltd.
Product
Dinoprost Tromethamine 38562-01-5
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
EP9.0, GMP, DMF
Supply Ability
20 tons
Release date
2024-06-27
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Dinoprost tromethamine 38562-01-5
Price
US $15.00/gram
Min. Order
10gram
Purity
99%
Supply Ability
50000 kilograms
Release date
2022-11-18
Nantong Guangyuan Chemicl Co,Ltd
Product
Dinoprost 38562-01-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-10-18

38562-01-5, Dinoprost tromethamineRelated Search:

Prostaglandin E2 Tricine BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) Fosfomycin tromethamine BIS-Tris Sodium chloride Ketorolac tromethamine Dienogestrel Tris(hydroxymethyl)aminomethane Dexketoprofen trometamol Prostaglandin F2a TRISTEARIN PROSTAGLANDIN H2 15(S)-15-Methyl prostaglandin Carboprost tromethamine PROSTAGLANDIN G2 Candicidin 19(R)-HYDROXY PROSTAGLANDIN F2ALPHA

  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Prostaglandin F2α THAM salt
  • Prostaglandin F2α tris(hydroxymethyl)aminomethane
  • Prostaglandin F2α tris(hydroxymethyl)aminomethane salt
  • Prostaglandin F2α tromethamine
  • Prostaglandin F2α tromethamine salt
  • Prostaglandin F2α-tham
  • THAM PGF2α
  • Tromethamine prostaglandin F2α
  • PGF2a-THAM
  • PGF2α-Tris, Prostaglandin F2α tris salt, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
  • PGF2α-Tris, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
  • PGF2αTris
  • Prostaglandin F2a tromethamine salt
  • PROSTAGLANDIN F2A TROMETHAMINE SALT;PGF2Α THAM;PROSTAGLANDIN F2Α THAM
  • DINOPROST TROMMETAMOL
  • 7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]-5-heptenoic acid
  • Dinoprost Prostaglandin F2α Tromethamine Salt
  • lutalyse
  • pgf2-alphatromethamine
  • pgf2-alphatromethaminesalt
  • prostaglandinf2-alphatham
  • prostaglandinf2-alphathamsalt
  • prostaglandinf2atromethamine
  • protaglandinf2-alpha-thamsalt
  • DINOPROST TROMETHAMINE
  • DINOPROST (TROMETHAMINE SALT)
  • dinoprost, trometamol salt
  • prostaglandin F2A tris
  • prostaglandin F2-alpha, trometamol salt
  • PROSTAGLANDIN F2A TRIS GAMMA-IRRADIATED CELL CULTUR
  • PROSTAGLANDIN F2A TRIS CELL*CULTURE TEST ED
  • [5Z,9ALPHA,11ALPHA,13E,15S]-9,11,15-TRIHYDROXYPROSTA-5,13-DIENOIC ACID TRIS SALT
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • (5z,9α,11α,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt
  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oate (salt) (9CI)
  • Minprostin F2α
  • NSC 196515
  • PGF2α THAM
  • PGF2α THAM salt
  • PGF2α Tris salt
  • PGF2α tromethamine
  • PGF2α tromethamine salt
  • Pronalgon F
  • (5z,9-alpha,11-alpha,13e,15s)-9,11,15-trihydroxy-prosta-13-dien-1-oicacid
  • 583e
  • 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet
  • Tromethamine salt
  • Dinoprostaglandin aminobutanol salt
  • PGF2α (Prostaglandin F2α)
  • Dinoprost TroMethaMine USP
  • Dinorprost tromethamine
  • (E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable
  • Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Ensaprost
  • Dinoprost Tromethamine (50 mg)
  • (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid 2-AMino-2-(hydroxyMethyl)-1,3-propanediol
  • 7-[3,5-Dihydroxy-2-(3-hydroxy-1- octenyl)cyclopentyl]-5-heptenoic Acid TroMethaMine