3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

Product Name: 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
CAS No.: 306936-57-2
Chemical Name: 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
Synonyms: AKOS B000254;AKOS PAO-0297;ART-CHEM-BB B000254;CHEMBRDG-BB 4301174;3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE;3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde;3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde;3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde;Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
CBNumber: CB9396160
Molecular Formula: C10H7FN2O
Formula Weight: 190.17
MOL File: 306936-57-2.mol

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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Property

Melting point:: 160 °C
Boiling point:: 416.0±35.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: powder to crystal
pka: 10.69±0.50(Predicted)
color: White to Orange to Green
Sensitive: Air Sensitive
CAS DataBase Reference: 306936-57-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 683272
Product name: 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $85
Updated: 2023/06/20

TCI Chemical

Product number: F1118
Product name: 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: F1118
Product name: 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $328
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK250171
Product name: 3-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde
Purity: 97%
Packaging: 1g
Price: $116
Updated: 2021/12/16

Apolloscientific

Product number: PC6717
Product name: 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
Purity: 97%
Packaging: 5g
Price: $117
Updated: 2021/12/16

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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow-orange solid

Synthesis

326-33-0

68-12-2

306936-57-2

General procedure for the synthesis of 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde from 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide and N,N-dimethylformamide: Phosphorochloride (2.1 mL, 23 mmol) was slowly added dropwise to N,N-dimethylformamide (4.4 mL, 57 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 30 min. Subsequently, the reaction mixture was cooled in an ice/water bath and 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide (1.96 g, 10 mmol) was slowly added, controlling the temperature not to exceed 50 °C. After the addition was completed, the reaction system was heated to 80 °C and stirred at this temperature for 2 hours. After completion of the reaction, the mixture was poured into ice (15 g) and the pH was adjusted to 10 with 5N NaOH solution and stirred for 2 hours. Subsequently, the reaction solution was acidified with concentrated hydrochloric acid and stirring was continued for 4 hours. The precipitated solid was collected by filtration, washed with a small amount of water and dried under high vacuum to give the target product 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde (1.5 g, 79% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 4932 - 4935
[2] Russian Journal of General Chemistry, 2005, vol. 75, # 5, p. 782 - 789
[3] Patent: WO2013/22766, 2013, A1. Location in patent: Page/Page column 87
[4] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 36 - 49
[5] Journal of Fluorine Chemistry, 2016, vol. 183, p. 59 - 68

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Sodium acetate Ethanol N,N-Dimethylformamide Phosphorus oxitrichloride 4-Fluoroacetophenone Semicarbazide hydrochloride

Preparation Products

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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Suppliers

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View Lastest Price from 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers

Career Henan Chemical Co

Product: 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 306936-57-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

306936-57-2, 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDERelated Search:

AKOS B000254

AKOS PAO-0297

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE

CHEMBRDG-BB 4301174

ART-CHEM-BB B000254

3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde

3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde 97%

3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde97%

3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)

Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-

3-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde ,97%

5-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde

3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde

3-(4-fluorophenyl)-2H-pyrazole-4-carboxaldehyde

JR-8855, 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde, 97%

3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

1H-Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-

3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde

3-(4-FLOURO PHENYLE) -1H-PYRAZOLE -4-CARBOXALDEHYDE

3-(4-Fluorophenyl)-1<i>H</i>-pyrazole-4-carboxaldehyde

306936-57-2

New Products for Chemical Synthesis May/June 2007

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