ChemicalBook > CAS DataBase List > METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE

METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE

Product Name: METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE
CAS No.: 1196-90-3
Chemical Name: METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE
Synonyms: Methyl 4-bromo-N-methyl-2-pyrrolecarboxylate;Methyl 4-bromo-1-methylpyrrole-2-carboxylate;Methyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxyl;4-Bromo-2-(methoxycarbonyl)-1-methyl-1H-pyrrole;METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE;Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate, ≥95%;1H-Pyrrole-2-carboxylic acid, 4-bromo-1-methyl-, methyl ester;methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate(SALTDATA: FREE)
CBNumber: CB9404456
Molecular Formula: C7H8BrNO2
Formula Weight: 218.05
MOL File: 1196-90-3.mol

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METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Property

Melting point:: 63-65°C
Boiling point:: 263.1±20.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: -10.16±0.70(Predicted)
color: Brown

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00082
Product name: Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate
Purity: AldrichCPR
Packaging: 1G
Price: $259
Updated: 2025/07/31

Sigma-Aldrich

Product number: 902861
Product name: Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate
Packaging: 1G
Price: $153
Updated: 2023/06/20

TRC

Product number: M296368
Product name: Methyl4-bromo-1-methylpyrrole-2-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 042890
Product name: Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate
Purity: >95%
Packaging: 1g
Price: $92
Updated: 2021/12/16

Apolloscientific

Product number: OR15346
Product name: Methyl4-bromo-1-methyl-1H-pyrrole-2-carboxylate
Packaging: 1g
Price: $167
Updated: 2021/12/16

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METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

124-41-4

184643-69-4

1196-90-3

To a stirred solution of 1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone (3.28 g, 10.74 mmol, 1 eq.) in anhydrous MeOH (30 mL) was slowly added sodium methanol solution (0.5 mL) using a syringe. Sodium methanol solution was prepared from 60% NaH in mineral oil (43 mg, 1.07 mmol, 0.1 equiv) and was pre-washed with hexane. The reaction mixture was heated to reflux for 30 min until TLC analysis showed complete consumption of the feedstock. Subsequently, a few drops of concentrated H2SO4 were added to the reaction solution to neutralize the base (pH 2). Excess MeOH was removed by vacuum evaporation and the resulting oil was redissolved in EtOAc (50 mL) and washed with deionized water (40 mL). The aqueous layer was back-extracted with EtOAc (3 x 40 mL), and the organic phases were combined, dried with anhydrous MgSO4, filtered and concentrated in vacuum to afford methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate as a light white solid (2.28 g, 97% yield). The product was confirmed by IR, 1H-NMR, 13C-NMR and EIMS characterization.

References

[1] Patent: WO2013/164592, 2013, A1. Location in patent: Page/Page column 50
[2] Patent: WO2013/164593, 2013, A1. Location in patent: Page/Page column 42
[3] Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 8151 - 8153
[4] Tetrahedron Letters, 1996, vol. 37, # 43, p. 7801 - 7804
[5] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 47 - 58

METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Suppliers

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View Lastest Price from METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE 1196-90-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-14

1196-90-3, METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATERelated Search:

Methyl 5-aMino-4-cyano-1H-pyrazole-1-carboxylate methyl 4-bromo-3-methyl-1H-pyrazole-5-carboxylate(SALTDATA: FREE) Methyl 5-broMo-1H-pyrazole-3-carboxylate METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE methyl 5-methoxy-1-methyl-1H-pyrazole-3-carboxylate METHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Potassium pyrrolidonecarboxylate Methyl triazole-3-carboxylate Pyrrole-2-carboxylic acid Methyl 2-pyrrolecarboxylate METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Methyl 4-bromopyrrole-2-carboxylate 4-BROMOPYRROLE-2-CARBOXYLIC ACID 1-(tert-Butyl) 2-methyl 4-bromo-1H-pyrrole-1,2-dicarboxylate 4-BROMO-PYRROLE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-ETHYL ESTER

METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE

Methyl 4-bromo-1-methylpyrrole-2-carboxylate

methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate(SALTDATA: FREE)

Methyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxyl

4-Bromo-2-(methoxycarbonyl)-1-methyl-1H-pyrrole

Methyl 4-bromo-N-methyl-2-pyrrolecarboxylate

1H-Pyrrole-2-carboxylic acid, 4-bromo-1-methyl-, methyl ester

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate, ≥95%

1196-90-3

Esters

Pyrroles & Indoles