ChemicalBook > CAS DataBase List > (PYRAZIN-2-YLMETHYL)AMINE

(PYRAZIN-2-YLMETHYL)AMINE

Product Name: (PYRAZIN-2-YLMETHYL)AMINE
CAS No.: 20010-99-5
Chemical Name: (PYRAZIN-2-YLMETHYL)AMINE
Synonyms: RARECHEM AL BW 0125;2-Pyrazinemethanamine;2-AMINOMETHYL PYRAZINE;2-(Aminomethyl)pyradine;(PYRAZIN-2-YLMETHYL)AMINE;2-Pyrazin-2-ylmethanamine;Pyrazinemethanamine (9CI);2-Aminomethylpyrazine ,97%;1-(2-Pyrazinyl)methanamine;2-(Aminomethyl)pyrazine 97%
CBNumber: CB9410178
Molecular Formula: C5H7N3
Formula Weight: 109.13
MOL File: 20010-99-5.mol

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(PYRAZIN-2-YLMETHYL)AMINE Property

Melting point:: 125 °C
Boiling point:: 117-118 °C
Density: 1.138g/ml
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
pka: 8.13±0.40(Predicted)
color: Clear, dark yellow
Stability:: Hygroscopic
InChI: InChI=1S/C5H7N3/c6-3-5-4-7-1-2-8-5/h1-2,4H,3,6H2
InChIKey: HQIBSDCOMQYSPF-UHFFFAOYSA-N
SMILES: C1(CN)=NC=CN=C1

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P3116
Product name: Pyrazin-2-ylmethanamine
Purity: min. 95.0 %
Packaging: 1G
Price: $51
Updated: 2025/07/31

TRC

Product number: A617440
Product name: 2-(Aminomethyl)pyrazine
Packaging: 1g
Price: $110
Updated: 2021/12/16

TRC

Product number: A617440
Product name: 2-(Aminomethyl)pyrazine
Packaging: 5g
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 068391
Product name: Pyrazin-2-ylmethanamine
Purity: >95%
Packaging: 1g
Price: $152
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-X2
Product name: 2-(Aminomethyl)pyrazine
Purity: 98%
Packaging: 5G
Price: $165
Updated: 2021/12/16

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(PYRAZIN-2-YLMETHYL)AMINE Chemical Properties,Usage,Production

Uses

2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition.

Synthesis

19847-12-2

20010-99-5

The general procedure for the synthesis of 2-aminomethylpyrazine from 2-cyanopyrazine is as follows: the method described in the literature (JP A 2001-894594) was referred to as follows. The raw material 2-cyanopyridine was purchased from Sigma-Aldrich Co. LLC. 1.05 g (10 mmol) of 2-cyanopyridine and 100 mg of 60 wt% Ni/SiO2 catalyst were placed in 20 mL of toluene and loaded into an autoclave (model 5U5316), followed by argon replacement of the air in the autoclave. The reaction was pressurized to 50 atm under hydrogen atmosphere and stirred at 140 °C reaction temperature for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to quantitatively obtain the target product 2-aminomethylpyridine (2-AMPZ). The product was characterized by 1H-NMR (399.78 MHz, CDCl3): δ 8.60-8.45 (m, 3H), 4.07 (s, 2H), 1.79 (br, 2H).

References

[1] Patent: US2015/31920, 2015, A1. Location in patent: Paragraph 0150; 0151; 0152
[2] Patent: EP2230241, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: EP2404921, 2012, A1. Location in patent: Page/Page column 9
[4] Patent: US2012/65209, 2012, A1. Location in patent: Page/Page column 9
[5] Patent: TWI522358, 2016, B. Location in patent: Page/Page column 15; 18

(PYRAZIN-2-YLMETHYL)AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (PYRAZIN-2-YLMETHYL)AMINE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: (PYRAZIN-2-YLMETHYL)AMINE 20010-99-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-21

Career Henan Chemical Co

Product: (PYRAZIN-2-YLMETHYL)AMINE 20010-99-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kgs
Release date: 2020-01-02

20010-99-5, (PYRAZIN-2-YLMETHYL)AMINERelated Search:

Pyrazinamide 6-Biopterin Lumazine 2-Amino-4-hydroxy-1H-pteridine LUMICHROME PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE ALLOXAZINE Aminopterin METHYL-PYRAZIN-2-YLMETHYL-AMINE,N-METHYL-N-(PYRAZIN-2-YLMETHYL)AMINE 2-AMINO-4-HYDROXYPTERIDINE-6-CARBOXYLIC ACID 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT 2,3-PYRAZINEDICARBOXAMIDE N10-(TRIFLUOROACETYL)PTEROIC ACID 6-METHYLPTERINE 6-hydroxymethylpterin D(-)-AMETHOPTERIN HYDRATE, 98 3',5'-DICHLOROFOLIC ACID

RARECHEM AL BW 0125

(PYRAZIN-2-YLMETHYL)AMINE

2-AMINOMETHYL PYRAZINE

2-(Aminomethyl)pyradine

1-Pyrazin-2-ylmethanamine hydrochloride

2-Pyrazin-2-ylmethanamine

2-Pyrazinemethanamine

2-Aminomethylpyrazine ,97%

(Pyrazin-2-yl)methylamine, 2-(Aminomethyl)-1,4-diazine

2-(Aminomethyl)pyrazine 97%

(PYRAZIN-2-YLMETHYL)AMINE ISO 9001：2015 REACH

Pyrazinemethanamine (9CI)

1-(2-Pyrazinyl)methanamine

20010-99-5

Nitrogen cyclic compounds

Piperazine series