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(PYRAZIN-2-YLMETHYL)AMINE

Product Name
(PYRAZIN-2-YLMETHYL)AMINE
CAS No.
20010-99-5
Chemical Name
(PYRAZIN-2-YLMETHYL)AMINE
Synonyms
RARECHEM AL BW 0125;2-Pyrazinemethanamine;2-AMINOMETHYL PYRAZINE;2-(Aminomethyl)pyradine;(PYRAZIN-2-YLMETHYL)AMINE;2-Pyrazin-2-ylmethanamine;Pyrazinemethanamine (9CI);2-Aminomethylpyrazine ,97%;1-(2-Pyrazinyl)methanamine;2-(Aminomethyl)pyrazine 97%
CBNumber
CB9410178
Molecular Formula
C5H7N3
Formula Weight
109.13
MOL File
20010-99-5.mol
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(PYRAZIN-2-YLMETHYL)AMINE Property

Melting point:
125 °C
Boiling point:
117-118 °C
Density 
1.138g/ml
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
liquid
pka
8.13±0.40(Predicted)
color 
Clear, dark yellow
Stability:
Hygroscopic
InChI
InChI=1S/C5H7N3/c6-3-5-4-7-1-2-8-5/h1-2,4H,3,6H2
InChIKey
HQIBSDCOMQYSPF-UHFFFAOYSA-N
SMILES
C1(CN)=NC=CN=C1
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P3116
Product name
Pyrazin-2-ylmethanamine
Purity
min. 95.0 %
Packaging
1G
Price
$51
Updated
2025/07/31
TRC
Product number
A617440
Product name
2-(Aminomethyl)pyrazine
Packaging
1g
Price
$110
Updated
2021/12/16
TRC
Product number
A617440
Product name
2-(Aminomethyl)pyrazine
Packaging
5g
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
068391
Product name
Pyrazin-2-ylmethanamine
Purity
>95%
Packaging
1g
Price
$152
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-X2
Product name
2-(Aminomethyl)pyrazine
Purity
98%
Packaging
5G
Price
$165
Updated
2021/12/16
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(PYRAZIN-2-YLMETHYL)AMINE Chemical Properties,Usage,Production

Uses

2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition.

Synthesis

19847-12-2

20010-99-5

The general procedure for the synthesis of 2-aminomethylpyrazine from 2-cyanopyrazine is as follows: the method described in the literature (JP A 2001-894594) was referred to as follows. The raw material 2-cyanopyridine was purchased from Sigma-Aldrich Co. LLC. 1.05 g (10 mmol) of 2-cyanopyridine and 100 mg of 60 wt% Ni/SiO2 catalyst were placed in 20 mL of toluene and loaded into an autoclave (model 5U5316), followed by argon replacement of the air in the autoclave. The reaction was pressurized to 50 atm under hydrogen atmosphere and stirred at 140 °C reaction temperature for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to quantitatively obtain the target product 2-aminomethylpyridine (2-AMPZ). The product was characterized by 1H-NMR (399.78 MHz, CDCl3): δ 8.60-8.45 (m, 3H), 4.07 (s, 2H), 1.79 (br, 2H).

References

[1] Patent: US2015/31920, 2015, A1. Location in patent: Paragraph 0150; 0151; 0152
[2] Patent: EP2230241, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: EP2404921, 2012, A1. Location in patent: Page/Page column 9
[4] Patent: US2012/65209, 2012, A1. Location in patent: Page/Page column 9
[5] Patent: TWI522358, 2016, B. Location in patent: Page/Page column 15; 18

(PYRAZIN-2-YLMETHYL)AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(PYRAZIN-2-YLMETHYL)AMINE Suppliers

China 147 Germany 1 India 3 Japan 4 Russia 1 Slovakia 1 United Kingdom 5 United States 18 Global 180
Chemical Block Ltd.
Tel
--
Fax
--
Email
orders@chemical-block.com
Country
Russia
ProdList
3905
Advantage
61
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View Lastest Price from (PYRAZIN-2-YLMETHYL)AMINE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
(PYRAZIN-2-YLMETHYL)AMINE 20010-99-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-21
Career Henan Chemical Co
Product
(PYRAZIN-2-YLMETHYL)AMINE 20010-99-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kgs
Release date
2020-01-02

20010-99-5, (PYRAZIN-2-YLMETHYL)AMINERelated Search:

Pyrazinamide 6-Biopterin Lumazine 2-Amino-4-hydroxy-1H-pteridine LUMICHROME PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE ALLOXAZINE Aminopterin METHYL-PYRAZIN-2-YLMETHYL-AMINE,N-METHYL-N-(PYRAZIN-2-YLMETHYL)AMINE 2-AMINO-4-HYDROXYPTERIDINE-6-CARBOXYLIC ACID 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT 2,3-PYRAZINEDICARBOXAMIDE N10-(TRIFLUOROACETYL)PTEROIC ACID 6-METHYLPTERINE 6-hydroxymethylpterin D(-)-AMETHOPTERIN HYDRATE, 98 3',5'-DICHLOROFOLIC ACID

  • RARECHEM AL BW 0125
  • (PYRAZIN-2-YLMETHYL)AMINE
  • 2-AMINOMETHYL PYRAZINE
  • 2-(Aminomethyl)pyradine
  • 1-Pyrazin-2-ylmethanamine hydrochloride
  • 2-Pyrazin-2-ylmethanamine
  • 2-Pyrazinemethanamine
  • 2-Aminomethylpyrazine ,97%
  • (Pyrazin-2-yl)methylamine, 2-(Aminomethyl)-1,4-diazine
  • 2-(Aminomethyl)pyrazine 97%
  • (PYRAZIN-2-YLMETHYL)AMINE ISO 9001：2015 REACH
  • Pyrazinemethanamine (9CI)
  • 1-(2-Pyrazinyl)methanamine
  • 20010-99-5
  • Nitrogen cyclic compounds
  • Piperazine series