ChemicalBook > CAS DataBase List > 4-(Aminomethyl)tetrahydro-2H-pyran

4-(Aminomethyl)tetrahydro-2H-pyran

Product Name
4-(Aminomethyl)tetrahydro-2H-pyran
CAS No.
130290-79-8
Chemical Name
4-(Aminomethyl)tetrahydro-2H-pyran
Synonyms
oxan-4-ylmethanamine;ASINEX-REAG BAS 07731534;4-Aminotetrahydro-4H-pyran;4-AMINOMETHYLTETRAHYDROPYRAN;4-AMINOMETYYLTETRAHYDROPYRAN;4-(Aminomethyl)tetrahydro...;4-(Aminomethyl) tetrahydro-2;4-(Aminomethyl)tetrahydropyrane;4-AMinoMethyltetrahydropyran 1GR;4-AMinoMethyltetrahydropyran 5GR
CBNumber
CB9418437
Molecular Formula
C6H13NO
Formula Weight
115.17
MOL File
130290-79-8.mol
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4-(Aminomethyl)tetrahydro-2H-pyran Property

Boiling point:
75 °C
Density 
1.02
refractive index 
1.4630-1.4670
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
clear liquid
pka
10.01±0.29(Predicted)
color 
Colorless to Light yellow
InChI
InChI=1S/C6H13NO/c7-5-6-1-3-8-4-2-6/h6H,1-5,7H2
InChIKey
IPBPLHNLRKRLPJ-UHFFFAOYSA-N
SMILES
C1OCCC(CN)C1
CAS DataBase Reference
130290-79-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C,Xn
Risk Statements 
34-41-37/38-22
Safety Statements 
26-36/37/39-45-39
RIDADR 
2735
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2550
Product name
4-Aminomethyltetrahydropyran
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$74
Updated
2025/07/31
TCI Chemical
Product number
A2550
Product name
4-Aminomethyltetrahydropyran
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$236
Updated
2025/07/31
TRC
Product number
A615885
Product name
4-Aminomethyltetrahydropyran
Packaging
2.5g
Price
$220
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0025391
Product name
4-AMINOMETHYLTETRAHYDROPYRAN
Purity
95.00%
Packaging
1G
Price
$605.22
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0025391
Product name
4-AMINOMETHYLTETRAHYDROPYRAN
Purity
95.00%
Packaging
5G
Price
$854.7
Updated
2021/12/16
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4-(Aminomethyl)tetrahydro-2H-pyran Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

4-Aminomethyltetrahydropyran is a reagent that is used in core modification in discovery of CC214-2 which is an orally available , selective inhibitor of mTOR kinase. 4-Aminomethyltetrahydropyran is also used as a reagent in the development of pyrazoloquinolines as PDE10A inhibitor for the treatment of schizophrenia.

Synthesis

4295-99-2

130290-79-8

Example 43 (Synthesis of 4-aminomethyltetrahydropyran): In a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 50.0 g of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 45 to 55 °C and 0.51 to 0.61 MPa pressure for 17 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined, concentrated under reduced pressure and then distilled under reduced pressure at 73-74 °C and 2.67 kPa to give 7.94 g (76.6% isolated yield) of 4-aminomethyltetrahydropyran as a colorless liquid. Its physical properties were as follows: 1H-NMR (DMSO-d6, δ (ppm)): 1.02-1.16 (2H, m), 1.10-1.50 (2H, brs), 1.34-1.45 (1H, m), 1.56-1.61 (2H, m), 2.39 (2H, d, J = 6.3 Hz), 3.20-3.29 (2H, m ), 3.81-3.86 (2H, m); CI-MS (m/e): 116 (M+1), 99. Example 45 (Synthesis of 4-aminomethyltetrahydropyran): in a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 100 mL of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 50 to 60 °C and 0.51 to 0.61 MPa pressure for 5 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined and analyzed by gas chromatography (internal standard method) to confirm the formation of 8.84 g (85.3% reaction yield) of 4-aminomethyltetrahydropyran and no by-product bis(4-tetrahydropyranosylmethyl)amine was detected.

References

[1] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 16-17
[2] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 17
[3] Justus Liebigs Annalen der Chemie, 1938, vol. 535, p. 37,45
[4] Patent: US6372778, 2002, B1. Location in patent: Example 80
[5] Patent: US2006/63804, 2006, A1. Location in patent: Page/Page column 13

4-(Aminomethyl)tetrahydro-2H-pyran Preparation Products And Raw materials

Raw materials

Hexane Ammonium hydroxide Ethanol Potassium hydroxide Acetone Ethyl propionate Potassium carbonate Sodium 2,2'-Dichlorodiethyl ether Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Diethyl malonate Dimethyl sulfate

Preparation Products

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View Lastest Price from 4-(Aminomethyl)tetrahydro-2H-pyran manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Henan Aochuang Chemical Co.,Ltd.
Product
4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

130290-79-8, 4-(Aminomethyl)tetrahydro-2H-pyranRelated Search:

Tetrahydro-4H-pyran-4-one Tetrahydropyran Methyl tetrahydrophthalic anhydride Tetramethylammonium hydroxide pentahydrate Proxorphan ENLOPLATIN 2-(Aminomethyl)tetrahydro-2H-pyran 4-(Aminomethyl)tetrahydro-2H-pyran hydrochloride AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID 2,4-DIMETHOXY-N-((4-PHENYL-TETRAHYDRO-2H-PYRAN-4-YL)METHYL)BENZAMIDE D-4'-TETRAHYDROPYRANYLGLYCINE TERT-BUTOXYCARBONYLAMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-AMINE [4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANOL 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxamide 4-(aminomethyl)tetrahydro-2H-pyran-4-ol 4-(Aminomethyl)tetrahydro-2H-pyran IFLAB-BB F0914-7227

  • C-(TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE
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  • oxan-4-ylmethanamine
  • (Aminomethyl)tetrahydro-2H-pyran
  • 1-(Tetrahydro-2H-pyran-4-yl)methylamine
  • 4-Aminotetrahydro-4H-pyran
  • 2H-Pyran-4-MethanaMine,tetrahydro-
  • (Tetrahydro-2H-pyran-4-yl)methylamine, 4-(Aminomethyl)oxane
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  • 4-(Aminomethyl) tetrahydro-2
  • 4-Aminomethyltetrahydropyran, 98%
  • 130290-79-8
  • Aminomethyl's
  • Pyrans, Piperidines & Piperazines
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