N-ACETYL-DL-PENICILLAMINE Property

Melting point:

186-189 °C (dec.)(lit.)

Density 

1.2684 (rough estimate)

refractive index 

1.6370 (estimate)

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml,Ethanol: 5 mg/ml

form 

A crystalline solid

pka

pK1: 9.90 (30°C)

Safety

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

YV9380000

F 

10-23

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

N-ACETYL-DL-PENICILLAMINE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

2-(acetylamino)-3-mercapto-3-methylbutanoic acid is an amino acid derivative.

Purification Methods

Both forms are recrystallised from hot H2O. A pure sample of the D-form is obtained after five recrystallisations. [Crooks in The Chemistry of Penicillin Clarke, Johnson and Robinson eds, Princeton University Press, 470 1949, Review: Chain et al. Antibiotics (Oxford University Press) 2 1949, Beilstein 4 III 1662.]