Diethyl L-malate

Product Name: Diethyl L-malate
CAS No.: 691-84-9
Chemical Name: Diethyl L-malate
Synonyms: DIETHYL L-(-)-MALATE;(S)-diethyl 2-hydroxysuccinate;DIETHYL L-MALATE;(S)-(-)-DIETHYLMALATE;Malicaciddiethylester;DiethylL-(-)-Malate>Malic Acid Impurity 14;L-MALIC ACID DIETHYL ESTER;691-84-9 Diethyl L-malate;L-Matic acid dimethyl ester
CBNumber: CB9428692
Molecular Formula: C8H14O5
Formula Weight: 190.19
MOL File: 691-84-9.mol

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Diethyl L-malate Property

alpha: -10.18°
Boiling point:: 253℃
Density: 1.13
refractive index: 1.4330 to 1.4370
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.35±0.20(Predicted)
form: Oil
color: Colourless
Specific Gravity: 1.1280 (20/4℃)
Dielectric constant: 9.5（20℃）
CAS DataBase Reference: 691-84-9(CAS DataBase Reference)

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Safety

HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1348
Product name: Diethyl L-(-)-Malate
Purity: >97.0%(GC)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: M1348
Product name: Diethyl L-(-)-Malate
Purity: >97.0%(GC)
Packaging: 25g
Price: $100
Updated: 2025/07/31

TRC

Product number: D444510
Product name: Diethyl L-(-)-Malate
Packaging: 10g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J54724
Product name: Diethyl L-(-)-Malate
Packaging: 5g
Price: $20
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0005210
Product name: DIETHYL L-(-)-MALATE
Purity: 95.00%
Packaging: 5G
Price: $129.15
Updated: 2021/12/16

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Diethyl L-malate Chemical Properties,Usage,Production

Uses

Diethyl L-(-)-Malate is a reagent in the stereoselective synthesis of crucigasterin A and antitumor activity of crucigasterin A, B, and D.

Definition

ChEBI: Diethyl L-malate is a 3-hydroxy carboxylic acid.

Synthesis

64-17-5

97-67-6

691-84-9

Step 1 (Synthesis of compound 34-2) (0217) L-malic acid (80 g, 600 mmol) was dissolved in anhydrous ethanol (500 mL) and thionyl chloride (100 mL, 1.5 mol) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 20 min, then warmed to room temperature and continued to stir overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was extracted with ethyl acetate (1000 mL x 3). The organic phases were combined and washed sequentially with water (500 mL×2) and saturated sodium chloride solution (500 mL×2), and the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent system: petroleum ether/ethyl acetate = 20:1) to afford diethyl (S)-2-hydroxysuccinate (113 g, 99% yield). (0218) 1H NMR (400 MHz, CDCl3) δ: 4.47 (q, J = 4.8 Hz, 1H), 4.26 (dq, J = 2.4, 7.2 Hz, 2H), 4.16 (q, J = 7.2 Hz, 2H), 3.28 (d, J = 4.8 Hz, 1H), 2.72-2.89 (m, 2H), 1.20- 1.34 (m, 6H).

References

[1] Patent: US2017/197986, 2017, A1. Location in patent: Paragraph 0216; 0217; 0218
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 969 - 974
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2015, vol. 53, # 22, p. 2586 - 2597
[4] European Journal of Organic Chemistry, 2012, # 5, p. 995 - 1002
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 18, p. 5192 - 5194

Diethyl L-malate Preparation Products And Raw materials

Raw materials

Preparation Products

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Diethyl L-malate Suppliers

Americas 1 China 101 Europe 1 France 2 Germany 3 India 3 Italy 1 Japan 4 The Netherlands 1 United Kingdom 6 United States 15 Global 138

HBCChem, Inc.

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View Lastest Price from Diethyl L-malate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Diethyl L-malate 691-84-9
Price: US $120.00-1200.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 200tons
Release date: 2025-08-19

Qingdao RENAS Polymer Material Co., Ltd.

Product: Diethyl L-malate 691-84-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-08-26

Career Henan Chemical Co

Product: L-Matic acid dimethyl ester 691-84-9
Price: US $30.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-01

691-84-9, Diethyl L-malateRelated Search:

CITRIC ACID TRI-N-PROPYL ESTER CITRIC ACID TRIALLYL ESTER Tributyl citrate Triethyl citrate STEARYL CITRATE Diisopropyl D-tartrate tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate Triethyl acetyl citrate Acetyl tributyl citrate (-)-DIBUTYL-D-TARTRATE (2S,3S)(-)-Dihydroxybutane-1,4-dioic acid diethyl ester TRIS(2-ETHYLHEXYL)CITRATE DIETHYL DL-MALATE,Diethyl DL-Malate, 99% (GC) DIETHYL DL-MALATE DIETHYL D-(+)-MALATE TRI-N-AMYL CITRATE (-)-DI-TERT-BUTYL D-TARTRATE (2S,3S)-(+)-DIETHYL 2,3-O-BENZYLIDENETARTRATE

(2S)-2-Hydroxybutanedioic acid diethyl ester

(S)-2-Hydroxybutanedioic acid diethyl ester

L-(-)-Apple Acid Diethyl Ester L-(-)-Malic Acid Diethyl Ester

(S)-diethyl 2-hydroxysuccinate

(S)-(-)-DIETHYL HYDROXYSUCCINATE

(S)-(-)-DIETHYLMALATE

(S)-2-HYDROXY-SUCCINIC ACID DIETHYL ESTER

DIETHYL L-(-)-MALATE

DIETHYL L-MALATE

L-(-)-MALIC ACID DIETHYL ESTER

L-MALIC ACID DIETHYL ESTER

L-(-)-APPLE ACID DIETHYL ESTER

Malicaciddiethylester

L-Matic acid dimethyl ester

DiethylL-(-)-Malate&gt

Malic Acid Impurity 14

Butanedioic acid, 2-hydroxy-, 1,4-diethyl ester, (2S)-

691-84-9 Diethyl L-malate

691-84-9

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