2,2-Difluoro-5-aminobenzodioxole

Product Name: 2,2-Difluoro-5-aminobenzodioxole
CAS No.: 1544-85-0
Chemical Name: 2,2-Difluoro-5-aminobenzodioxole
Synonyms: IFLAB-BB F2108-0168;Paroxetine Impurity 88;5-AMINO-2,2-DIFLUOROBENZODIOXOLE;2,2-DIFLUORO-5-AMINOBENZODIOXOLE;2,2-Difluoro-5-aminobenzodioxole98%;2,2-DIFLUORO-1,3-BENZODIOXOL-5-AMINE;2,2-Difluoro-5-aminobenzodioxole 98%;5-AMino-2,2-difluoro-1,3-benzdioxole;3,4-[(Difluoromethylene)dioxy]aniline;2,2-DIFLUORO-5-AMINO-1,3-BENZODIOXOLE
CBNumber: CB9441174
Molecular Formula: C7H5F2NO2
Formula Weight: 173.12
MOL File: 1544-85-0.mol

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2,2-Difluoro-5-aminobenzodioxole Property

Boiling point:: 95-97°C 12mm
Density: 1.51±0.1 g/cm3(Predicted)
refractive index: 1.498
Flash point:: 95-97°C/12mm
storage temp.: Keep in dark place,Sealed in dry,2-8°C
pka: 4.18±0.40(Predicted)
form: clear liquid
color: Colorless to Brown
Water Solubility: Not miscible or difficult to mix in water.
Sensitive: Light Sensitive
BRN: 1343593
InChI: InChI=1S/C7H5F2NO2/c8-7(9)11-5-2-1-4(10)3-6(5)12-7/h1-3H,10H2
InChIKey: CVYQRDKVWVBOFP-UHFFFAOYSA-N
SMILES: O1C2=CC=C(N)C=C2OC1(F)F
CAS DataBase Reference: 1544-85-0(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 20/21/22-36/37/38-52-43-36
Safety Statements: 26-36/37/39-36/37
RIDADR: 2811
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3107
Product name: 5-Amino-2,2-difluoro-1,3-benzodioxole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $83
Updated: 2025/07/31

TCI Chemical

Product number: A3107
Product name: 5-Amino-2,2-difluoro-1,3-benzodioxole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $328
Updated: 2025/07/31

TRC

Product number: D452193
Product name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 007844
Product name: 2,2-Difluoro-5-aminobenzodioxole
Packaging: 1g
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD42943
Product name: 2,2-Difluoro-5-aminobenzodioxole
Packaging: 1g
Price: $60
Updated: 2021/12/16

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2,2-Difluoro-5-aminobenzodioxole Chemical Properties,Usage,Production

Uses

5-Amino-2,2-difluoro-1,3-benzodioxole is used as a pharmaceutical intermediate.

Synthesis

1645-96-1

1544-85-0

Under nitrogen atmosphere, 2,2-difluoro-5-nitro-1,3-benzodioxolane (69.1, 0.5 g, 2.46 mmol, 1.0 eq.) was dissolved in methanol (3.0 mL) and this solution was added to a 10% palladium/carbon (0.05 g) suspension in methanol (5.0 mL). Subsequently, the reaction system was purged with hydrogen for 2 hours. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with methanol. The collected filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by n-hexane milling to finally give 2,2-difluorobenzo[d][1,3]dioxolan-5-amine (69.2, 0.31 g, 72.5% yield). Mass spectrum (electrospray ionization): m/z 173.12 [M + H]+.

References

[1] Journal of Organic Chemistry, 2008, vol. 73, # 17, p. 6780 - 6783
[2] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0895; 0896; 0897

2,2-Difluoro-5-aminobenzodioxole Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Difluoro-5-aminobenzodioxole Suppliers

Americas 1 Canada 1 China 91 Europe 1 France 1 Germany 4 India 3 Italy 1 Japan 1 Ukraine 1 United Kingdom 10 United States 21 Global 136

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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View Lastest Price from 2,2-Difluoro-5-aminobenzodioxole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,2-Difluoro-5-aminobenzodioxole 1544-85-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

Henan Fengda Chemical Co., Ltd

Product: 2,2-Difluoro-5-aminobenzodioxole 1544-85-0
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Career Henan Chemical Co

Product: 2,2-Difluoro-5-aminobenzodioxole 1544-85-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-23

1544-85-0, 2,2-Difluoro-5-aminobenzodioxoleRelated Search:

ANILINE BLACK 1,3-Benzodioxole 1,5-Diphenylcarbazide Aniline ALTRENOGEST 4,4'-Methylenedianiline 4,4'-Diaminodiphenylsulfone 4-Aminobenzoic acid Glycine 4-Diethylaminobenzaldehyde 6-Aminocaproic acid 2-Aminophenol Tris(hydroxymethyl)aminomethane Anthranilic acid 2,2-DIFLUORO-5-NITRO-1,3-BENZODIOXOLE 2,2-DIFLUORO-4-AMINOBENZODIOXOLE 2,2-Difluoro-1,3-benzodioxole 5-AMINO-6-BROMO-2,2-DIFLUOROBENZODIOXOLE

IFLAB-BB F2108-0168

2,2-Difluoro-1,3-benzodioxol-5-ylamine

2,2-Difluoro-5-aminobenzodioxole 98%

2,2-Difluoro-5-aminobenzodioxole98%

2,2-DIFLUORO-1,3-BENZODIOXOL-5-AMINE

2,2-DIFLUORO-5-AMINOBENZODIOXOLE

2,2-DIFLUORO-5-AMINO-1,3-BENZODIOXOLE

2,2-DIFLUORO-BENZO[1,3]DIOXOL-5-YLAMINE

5-AMINO-2,2-DIFLUORO-1,3-BENZODIOXOLE

5-AMINO-2,2-DIFLUOROBENZODIOXOLE

3,4-[(Difluoromethylene)dioxy]aniline

5-Amino-2,2-difluoro-1,3-benzodioxole, 97+%

2,2-difluorobenzo[d][1,3]dioxol-5-amine

5-Amino-2,2-difluoro-1,3-benzodioxole 98%

5-AMino-2,2-difluoro-1,3-benzdioxole

1,3-Benzodioxol-5-aMine,2,2-difluoro-

2,2-Difluoro-1,3-benzodioxol-5-amine, 3,4-(Difluoromethylenedioxy)aniline

2,2-Difluoro-5-aminobenzo[d][1,3]dioxole

2,2-difluoro-2H-1,3-benzodioxol-5-amine

2,2-Difluorobenzod1,3dioxol-5-ylamine

Paroxetine Impurity 88

1544-85-0

Heterocycles series