2,3-Dimethylanisole
- Product Name
- 2,3-Dimethylanisole
- CAS No.
- 2944-49-2
- Chemical Name
- 2,3-Dimethylanisole
- Synonyms
- 3-METHOXY-O-XYLENE;2,3-DIMETHYLANISOLE;2,3-Dimethylanisole>2,3-DIMETHYLANISOLE 97%;2,3-Dimethylanisole,97%;1,2-Dimethyl-6-methoxybenzene;1-Methoxy-2,3-dimethylbenzene;1,2-Dimethyl-3-methoxybenzene;2,3-DiMethylanisole, 97% 100GR;2,3-Dimethylphenol methyl ether
- CBNumber
- CB9441765
- Molecular Formula
- C9H12O
- Formula Weight
- 136.19
- MOL File
- 2944-49-2.mol
2,3-Dimethylanisole Property
- Melting point:
- 29 °C(lit.)
- Boiling point:
- 195 °C(lit.)
- Density
- 0.984 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.52(lit.)
- Flash point:
- 155 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to lump
- Specific Gravity
- 0.984
- color
- White to Almost white
- Water Solubility
- immiscible
- BRN
- 1859736
- InChI
- InChI=1S/C9H12O/c1-7-5-4-6-9(10-3)8(7)2/h4-6H,1-3H3
- InChIKey
- BLMBNEVGYRXFNA-UHFFFAOYSA-N
- SMILES
- C1(OC)=CC=CC(C)=C1C
- LogP
- 3.211 (est)
- CAS DataBase Reference
- 2944-49-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,3-Dimethylanisole(2944-49-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D2200
- Product name
- 2,3-Dimethylanisole
- Purity
- >98.0%(GC)
- Packaging
- 10mL
- Price
- $40
- Updated
- 2025/07/31
- Product number
- D459970
- Product name
- 2,3-Dimethylanisole
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK545562
- Product name
- 2,3-Dimethylanisole
- Purity
- 98%
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- FD64635
- Product name
- 2,3-Dimethylanisole
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-M2533
- Product name
- Benzene,1-methoxy-2,3-dimethyl-
- Purity
- >97.0%
- Packaging
- 25g
- Price
- $68
- Updated
- 2021/12/16
2,3-Dimethylanisole Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid
Uses
2,3-Dimethylanisole is used as starting reagent in the synthesis of biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2. It can be used to produce 2-methoxy-6-methyl-benzaldehyde by heating.
Synthesis
526-75-0
616-38-6
2944-49-2
General procedure: 1-methoxy-2,3-dimethylbenzene was synthesized by alkylation of 2,3-dimethylphenol with dimethyl carbonate. The specific operation was as follows: 3 mmol of Mn2(CO)10, W(CO)6 or Co2(CO)8 catalyst, 100 mmol of 2,3-dimethylphenol, and 300 mmol of dimethyl carbonate were sequentially added to a 17 mL stainless steel high-pressure microreactor. After sealing the reactor, the reaction was heated at 180 °C for 1 hour. Upon completion of the reaction, the reactor was cooled to room temperature, opened and the reaction mixture was filtered through an alumina layer. The unreacted dimethyl carbonate was removed by distillation, and the residue was distilled under atmospheric or reduced pressure conditions or recrystallized using ethanol to obtain the target product 1-methoxy-2,3-dimethylbenzene. The yield of the reaction was 99% and the boiling point of the product was 95.8-96 °C (30 mmHg).13C NMR data (δC, ppm): 11.99 (CH3), 20.56 (CH3), 55.83 (OCH3), 110.02 (C6), 122.43 (C4), 124.78 (C2), 128.74 (C5). 137.70 (C3), 157.36 (C1). Elemental analysis results (measured values): C 79.29%, H 8.82%; calculated values for molecular formula C9H12O: C 79.37%, H 8.88%.
References
[1] Russian Journal of Organic Chemistry, 2015, vol. 51, # 3, p. 330 - 334
[2] Methylation of Phenol and Its Derivatives with Dimethyl Carbonate in the Presence of Mn2(CO)10, W(CO)6, and Co2(CO)8, 2015, vol. 51, # 3, p. 330 - 334,5
2,3-Dimethylanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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