ChemicalBook > CAS DataBase List > 2-Chloro-5-pyridineacetonitrile

2-Chloro-5-pyridineacetonitrile

Product Name
2-Chloro-5-pyridineacetonitrile
CAS No.
39891-09-3
Chemical Name
2-Chloro-5-pyridineacetonitrile
Synonyms
2-Chloro-5-pyridinea;2-chloro-5-acetonitrile;oro-5-pyridineacetonitriL;2-CHLORO-5-PYRIDINEACETONITRILE;2-CHLOROPYRIDINE-5-ACETONITRILE;6-Chloro-3-pyridineacetonitrile;6-Chloro-3-(cyanomethyl)pyridine;2-CHLORO-5-(CYANOMETHYL)PYRIDINE;3-Pyridineacetonitrile, 6-chloro-;2-(6-chloropyridin-3-yl)acetonitrile
CBNumber
CB9450903
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
39891-09-3.mol
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2-Chloro-5-pyridineacetonitrile Property

Melting point:
49-54°C
Boiling point:
182 °C(Press: 1 Torr)
Density 
1.262±0.06 g/cm3(Predicted)
Flash point:
>110℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-1.02±0.10(Predicted)
Appearance
Brown to reddish brown Solid
InChI
InChI=1S/C7H5ClN2/c8-7-2-1-6(3-4-9)5-10-7/h1-2,5H,3H2
InChIKey
BLGUCBUETMYJTB-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC=C1CC#N
CAS DataBase Reference
39891-09-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T,Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
RIDADR 
UN 3439 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT, TOXIC
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
734810
Product name
2-Chloropyridine-5-acetonitrile
Purity
95%
Packaging
5g
Price
$40.97
Updated
2025/07/31
TRC
Product number
C380763
Product name
2-Chloro-5-cyanomethylpyridine
Packaging
1g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC10678
Product name
2-Chloro-5-(cyanomethyl)pyridine
Packaging
5G
Price
$40
Updated
2021/12/16
AK Scientific
Product number
N420
Product name
2-Chloro-5-pyridineacetonitrile
Packaging
5g
Price
$54
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC10678
Product name
2-Chloro-5-(cyanomethyl)pyridine
Packaging
10g
Price
$70
Updated
2021/12/16
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2-Chloro-5-pyridineacetonitrile Chemical Properties,Usage,Production

Uses

2-Chloro-5-cyanomethylpyridine

Synthesis

773837-37-9

70258-18-3

39891-09-3

General procedure for the synthesis of 2-chloro-5-pyridylacetonitrile from 2-chloro-5-chloromethylpyridine and sodium cyanide: Step 1. Synthesis of (6-chloropyridin-3-yl)acetonitrile. To a stirred solution of 2-chloro-5-chloromethylpyridine (25 g, 0.154 mol) in ethanol (40 mL) was slowly added an aqueous solution of sodium cyanide (8.17 g, 0.167 mol) (18 mL) at 0 °C. The reaction mixture was heated to reflux for 2 hours, followed by continued stirring at room temperature for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was dissolved in water and extracted with dichloromethane (500 mL). The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with the eluent being a 70/30 dichloromethane/hexane solvent mixture to give 20 g (85% yield) of brown oily product. The product was solidified by standing and ESI-MS m/z 153 (MH+).

References

[1] Patent: WO2010/130708, 2010, A1. Location in patent: Page/Page column 105
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2168 - 2173
[3] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 111
[4] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 221
[5] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0705

2-Chloro-5-pyridineacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-pyridineacetonitrile Suppliers

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View Lastest Price from 2-Chloro-5-pyridineacetonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-5-pyridineacetonitrile 39891-09-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-5-pyridineacetonitrile 39891-09-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
2-Chloro-5-pyridineacetonitrile 39891-09-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26

39891-09-3, 2-Chloro-5-pyridineacetonitrileRelated Search:

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