ChemicalBook > CAS DataBase List > (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
139115-92-7
Chemical Name
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbaMate;BocNH-PEG3-OH;tert-butyl N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamate;Boc-NH-PEG3;NHBoc-PEG3-OH;PROTAC Linker 10;N-Boc-PEG3-alcohol;BocNH-PEG3-alcohol;t-Boc-Amido-PEG3-Alcohol;t-boc-N-amido-PEG3-alcohol
CBNumber
CB9451647
Molecular Formula
C11H23NO5
Formula Weight
249.3
MOL File
139115-92-7.mol
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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:
374.6±27.0 °C(Predicted)
Density 
1.071±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
pka
12.22±0.46(Predicted)
color 
Colourless to Pale Yellow
Stability:
Light and Moisture Sensitive
InChI
InChI=1S/C11H23NO5/c1-11(2,3)17-10(14)12-4-6-15-8-9-16-7-5-13/h13H,4-9H2,1-3H3,(H,12,14)
InChIKey
FMLOTGGIHAYZLW-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NCCOCCOCCO
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Safety

HS Code 
2924190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30496
Product name
Boc-NH-PEG3-OH
Packaging
50mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
30496
Product name
Boc-NH-PEG3-OH
Packaging
100mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
30496
Product name
Boc-NH-PEG3-OH
Packaging
250mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
30496
Product name
Boc-NH-PEG3-OH
Packaging
500mg
Price
$356
Updated
2024/03/01
TRC
Product number
B618580
Product name
2-[2-(2-t-Boc-aminoethoxy]ethoxy]ethanol
Packaging
250mg
Price
$145
Updated
2021/12/16
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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Description

N-Boc-PEG3-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Colourless Oil

Uses

A cross-linking reagent

Synthesis

6338-55-2

24424-99-5

139115-92-7

GENERAL STEPS: Di-tert-butyl dicarbonate (1.75 g, 8.04 mmol) was slowly added to a solution of 2-[2-(2-aminoethoxy)ethoxy]ethanol (600 mg, 4.02 mmol) dissolved in a mixture of methanol/triethylamine (68 mL, 9:1, v/v). The reaction mixture was stirred under reflux conditions. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was separated by extraction with dichloromethane (DCM) and water. The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure to afford tert-butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate (902 mg, 90% yield). Product characterization: light yellow oil; 1H NMR (400 MHz, CDCl3) δ 3.77-3.71 (m, 2H), 3.66-3.55 (m, 8H), 3.49-3.31 (m, 2H), 1.45 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 156.2, 79.9, 73.0. 70.6, 70.5, 70.0, 61.9, 40.5, 28.6; HRMS (ESI) calculated value C11H24NO5 ([M+H]+) 250.1654, measured value 250.1649.

IC 50

PEGs

References

[1] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1697 - 1706
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4443 - 4450
[3] Tetrahedron, 2011, vol. 67, # 49, p. 9588 - 9594
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7029 - 7043
[5] Inorganica Chimica Acta, 2011, vol. 365, # 1, p. 38 - 48

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

LAURENT
Product
BocNH-PEG3-OH 139115-92-7
Price
US $8246.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
300kg
Release date
2025-11-18
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate 139115-92-7
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-06
Xian confluore Biological Technology Co., Ltd.
Product
NHBoc-PEG3-OH 139115-92-7
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
100g
Release date
2024-03-25

139115-92-7, (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID BOC-11-AMINO-3,6,9-TRIOXAUNDECANOIC ACID DCHA ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID DODECA(ETHYLENE GLYCOL) O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)DECAETHYLENE GLYCOL O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID 1-BOC-AMINO-3,6,9-TRIOXAUNDECANYL-11-BROMIDE O-(2-(BOC-AMINO)-ETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG6 N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID OCTA(ETHYLENE GLYCOL) 2-[2-[2-(2-T-BOC-AMINOETHOXY]ETHOXY]ETHOXY]-4-[3-(TRIFLUOROMETHYL)-3H-DIAZIRIN-3-YL]BENZOIC ACID, METHYL ESTER 3-(11-BOC-AMINO-3,6,9-TRIOXAUNDECANOXY)BENZOIC ACID METHYL ESTER BOC-PEG-ACID BOC-8-AMINO-3,6-DIOXAOCTANOIC ACID DCHA O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)

  • 2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHANOL
  • (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
  • 2-[2-(2-tert-ButyloxycarbonylaMinoethoxy)ethoxy]ethanol
  • N-[2-[2-(2-Hydroxyethoxy)ethoxy]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester
  • BocNH-PEG3-OH
  • 2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethanol
  • NHBoc-PEG3-OH
  • tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbaMate
  • tert-butyl N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamate
  • N-Boc-PEG3-alcohol
  • PROTAC Linker 10
  • Carbamic acid, N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
  • t-boc-N-amido-PEG3-alcohol
  • (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH
  • Boc-NH-PEG3
  • Boc-NH-PEG3： tert-butyl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate
  • PROTAC Linker10,PROTAC Linker-10,Boc-NH-PEG-3,Inhibitor,BocNHPEG3,PROTAC Linkers,inhibit,Boc NH PEG3
  • BocNH-PEG3-OH/Carbamic acid, N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
  • BocNH-PEG3-alcohol
  • t-Boc-Amido-PEG3-Alcohol
  • 139115-92-7
  • Nitric Oxide Reagents
  • Cross Linking Reagents
  • peg