(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 139115-92-7
Chemical Name: (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbaMate;BocNH-PEG3-OH;tert-butyl N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamate;Boc-NH-PEG3;NHBoc-PEG3-OH;PROTAC Linker 10;N-Boc-PEG3-alcohol;BocNH-PEG3-alcohol;t-Boc-Amido-PEG3-Alcohol;t-boc-N-amido-PEG3-alcohol
CBNumber: CB9451647
Molecular Formula: C11H23NO5
Formula Weight: 249.3
MOL File: 139115-92-7.mol

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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 374.6±27.0 °C(Predicted)
Density: 1.071±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
pka: 12.22±0.46(Predicted)
color: Colourless to Pale Yellow
Stability:: Light and Moisture Sensitive
InChI: InChI=1S/C11H23NO5/c1-11(2,3)17-10(14)12-4-6-15-8-9-16-7-5-13/h13H,4-9H2,1-3H3,(H,12,14)
InChIKey: FMLOTGGIHAYZLW-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCOCCO

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30496
Product name: Boc-NH-PEG3-OH
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 30496
Product name: Boc-NH-PEG3-OH
Packaging: 100mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 30496
Product name: Boc-NH-PEG3-OH
Packaging: 250mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 30496
Product name: Boc-NH-PEG3-OH
Packaging: 500mg
Price: $356
Updated: 2024/03/01

TRC

Product number: B618580
Product name: 2-[2-(2-t-Boc-aminoethoxy]ethoxy]ethanol
Packaging: 250mg
Price: $145
Updated: 2021/12/16

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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Description

N-Boc-PEG3-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Colourless Oil

Uses

A cross-linking reagent

Synthesis

6338-55-2

24424-99-5

139115-92-7

GENERAL STEPS: Di-tert-butyl dicarbonate (1.75 g, 8.04 mmol) was slowly added to a solution of 2-[2-(2-aminoethoxy)ethoxy]ethanol (600 mg, 4.02 mmol) dissolved in a mixture of methanol/triethylamine (68 mL, 9:1, v/v). The reaction mixture was stirred under reflux conditions. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was separated by extraction with dichloromethane (DCM) and water. The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure to afford tert-butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate (902 mg, 90% yield). Product characterization: light yellow oil; 1H NMR (400 MHz, CDCl3) δ 3.77-3.71 (m, 2H), 3.66-3.55 (m, 8H), 3.49-3.31 (m, 2H), 1.45 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 156.2, 79.9, 73.0. 70.6, 70.5, 70.0, 61.9, 40.5, 28.6; HRMS (ESI) calculated value C11H24NO5 ([M+H]+) 250.1654, measured value 250.1649.

IC 50

PEGs

References

[1] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1697 - 1706
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4443 - 4450
[3] Tetrahedron, 2011, vol. 67, # 49, p. 9588 - 9594
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7029 - 7043
[5] Inorganica Chimica Acta, 2011, vol. 365, # 1, p. 38 - 48

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

Canada 1 China 142 India 3 United Kingdom 2 United States 15 Global 163

A.J Chemicals

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View Lastest Price from (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

LAURENT

Product: BocNH-PEG3-OH 139115-92-7
Price: US $8246.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate 139115-92-7
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Xian confluore Biological Technology Co., Ltd.

Product: NHBoc-PEG3-OH 139115-92-7
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 100g
Release date: 2024-03-25

139115-92-7, (2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID BOC-11-AMINO-3,6,9-TRIOXAUNDECANOIC ACID DCHA ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID DODECA(ETHYLENE GLYCOL) O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)DECAETHYLENE GLYCOL O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID 1-BOC-AMINO-3,6,9-TRIOXAUNDECANYL-11-BROMIDE O-(2-(BOC-AMINO)-ETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG6 N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID OCTA(ETHYLENE GLYCOL) 2-[2-[2-(2-T-BOC-AMINOETHOXY]ETHOXY]ETHOXY]-4-[3-(TRIFLUOROMETHYL)-3H-DIAZIRIN-3-YL]BENZOIC ACID, METHYL ESTER 3-(11-BOC-AMINO-3,6,9-TRIOXAUNDECANOXY)BENZOIC ACID METHYL ESTER BOC-PEG-ACID BOC-8-AMINO-3,6-DIOXAOCTANOIC ACID DCHA O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)

2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHANOL

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

2-[2-(2-tert-ButyloxycarbonylaMinoethoxy)ethoxy]ethanol

N-[2-[2-(2-Hydroxyethoxy)ethoxy]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester

BocNH-PEG3-OH

2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethanol

NHBoc-PEG3-OH

tert-Butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbaMate

tert-butyl N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamate

N-Boc-PEG3-alcohol

PROTAC Linker 10

Carbamic acid, N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester

t-boc-N-amido-PEG3-alcohol

(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

Boc-NH-PEG3

Boc-NH-PEG3： tert-butyl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate

PROTAC Linker10,PROTAC Linker-10,Boc-NH-PEG-3,Inhibitor,BocNHPEG3,PROTAC Linkers,inhibit,Boc NH PEG3

BocNH-PEG3-OH/Carbamic acid, N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester

BocNH-PEG3-alcohol

t-Boc-Amido-PEG3-Alcohol

139115-92-7

Nitric Oxide Reagents

Cross Linking Reagents

peg