ChemicalBook > CAS DataBase List > Phenylmethylsulfonyl fluoride

Phenylmethylsulfonyl fluoride

Product Name
Phenylmethylsulfonyl fluoride
CAS No.
329-98-6
Chemical Name
Phenylmethylsulfonyl fluoride
Synonyms
PMSF;PHENYLMETHANESULFONYL FLUORIDE;TOSYL FLUORIDE;α-toluenesulphonyl fluoride;4-METHYLBENZENESULFONYL FLUORIDE;abs9146;PMSF PLUS;PMSF, PMs-F;BCS ASSAY KIT;PMSF solution
CBNumber
CB9454820
Molecular Formula
C7H7FO2S
Formula Weight
174.19
MOL File
329-98-6.mol
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Phenylmethylsulfonyl fluoride Property

Melting point:
92-95 °C
Boiling point:
112 °C16 mm Hg(lit.)
Density 
0.797 g/mL at 20 °C
Flash point:
222 °F
storage temp. 
2-8°C
solubility 
dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C.
form 
Needles (May Agglomerate)
pka
7.0
color 
White
biological source
synthetic
Water Solubility 
hydrolysis
Sensitive 
Moisture Sensitive
Merck 
14,7542
BRN 
2088311
Stability:
Moisture Sensitive
InChIKey
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
CAS DataBase Reference
329-98-6(CAS DataBase Reference)
EPA Substance Registry System
Benzenemethanesulfonyl fluoride (329-98-6)
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Safety

Hazard Codes 
F,T,C
Risk Statements 
11-34-25-23/24/25
Safety Statements 
7-16-45-36/37/39-28A-26-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
XT8050000
F 
3-10-21
Hazard Note 
Highly Toxic/Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29241990
Toxicity
LD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PMSF-RO
Product name
PMSF
Purity
Phenylmethylsulfonyl fluoride
Packaging
10g
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
PMSF-RO
Product name
PMSF
Purity
Phenylmethylsulfonyl fluoride
Packaging
25g
Price
$314
Updated
2024/03/01
Sigma-Aldrich
Product number
93482
Product name
Phenylmethanesulfonyl fluoride solution
Purity
~0.1?M in ethanol (T)
Packaging
50mL
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
93482
Product name
Phenylmethanesulfonyl fluoride solution
Purity
~0.1?M in ethanol (T)
Packaging
250ML
Price
$572
Updated
2024/03/01
Sigma-Aldrich
Product number
7110-OP
Product name
OmniPur Phenylmethyl Sulfonyl Fluoride - CAS 329-98-6 - Calbiochem
Packaging
5G
Price
$93.3
Updated
2024/03/01
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Phenylmethylsulfonyl fluoride Chemical Properties,Usage,Production

Chemical Properties

White to cream solid

Uses

PMSF is an irreversible serine/cysteine protease inhibitor

Uses

Phenylmethylsulfonyl fluoride is used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase.

Uses

Standard protease inhibitor in biological research; in protein purification to prevent proteolytic degradation.

Definition

ChEBI: Phenylmethanesulfonyl fluoride is an acyl fluoride with phenylmethanesulfonyl as the acyl group. It has a role as a serine proteinase inhibitor. It derives from a phenylmethanesulfonic acid.

General Description

In biochemistry, Phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor commonly used in preparation of cell lysates. It is rapidly degraded in water and stock solutions are usually made up in anhydrous ethanol, isopropanol, corn oil, or DMSO (Dimethyl sulfoxide).    

Hazard

Extremely corrosive and destructive to tissues. May cause irreversible eye damage. PMSF hydrolyzes upon exposure to water/moisture, liberating a toxic and corrosive gas (hydrogen flouride) that in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.

Biological Activity

pmsf (phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy. it has a role in a lot of cellular repair and regeneration processes in many kinds of tissues. pmsf is a long acting neuropathy target esterase (nte) inhibitor. nte is a protection was related to inhibition of the putative target of organophosphate-induced delayed polyneuropathy (opidp). pmsf can increase nte inhibition to more than 90%. pmsf also acts as an active site directed reagent for γ-glutamyl transpeptidase.thomas baker, herbert e. lowndes, martin k. johnson, irene c. sandborg. the effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy. archives of toxicology. 1980; 46(3-4): 305 – 311.marcello lotti, stefano caroldi, eugenio capodicasa, angelo moretto. promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride. toxicology and applied pharmacology. 1991; 108(2): 234 – 241.masayasu inoue, seikoh horiuchi, yoshimasa morino. inactivation of γ-glutamyl transpeptidase by phenylmethanesulfonyl fluoride, a specific inactivator of serine enzymes. biochemical and biophysical research communications. 1978; 82(4): 1183 – 1188.

Biochem/physiol Actions

Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.

storage

Desiccate at RT

storage

Phenylmethylsulfonyl fluoride (PMSF) is incompatible with water, acids, bases, and strong oxidizing agents. Do not store PMSF in glass or mild steel/galvanized containers. Store in a cool, dry, and well-ventilated area away from incompatible chemicals.

Purification Methods

Purify PMSF by recrystallisation from *C6H6, pet ether or CHCl3/pet ether. [Davies & Dick J Chem Soc 483 1932, cf Tullock & Coffman J Org Chem 23 2016 1960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney & Gould J Am Chem Soc 85 997 1963]. [Beilstein 11 III 331.]

Phenylmethylsulfonyl fluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Phenylmethylsulfonyl fluoride manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Phenylmethylsulfonyl fluoride 329-98-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-25
Hebei Weibang Biotechnology Co., Ltd
Product
Phenylmethylsulfonyl fluoride 329-98-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
Phenylmethylsulfonyl fluoride 329-98-6
Price
US $19.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
50 ton
Release date
2024-08-23

329-98-6, Phenylmethylsulfonyl fluorideRelated Search:

SULFURYL FLUORIDE Aluminum fluoride Sulfosulfuron Dimethyl sulfone PHENYLGLYOXAL MONOHYDRATE Diethylstilbestrol 4'-(Trifluoromethyl)acetophenone 4-Fluorobenzenesulfonyl chloride Methyl benzoylformate TRIFLUOROMETHANESULFONYL FLUORIDE 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzoic acid Benzoyl peroxide FLUORIDE STANDARD 4-chloro-2-cyclopropylpyrimidine 3-Mercaptopropionic acid POPSO Phenylmethanesulfonyl Fluoride

  • α-toluenesulphonyl fluoride
  • Phenylmethanesulfonyl fluoride,α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride
  • Phenylmethanesulfony
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  • PMSF, Phenylmethanesulphonyl fluoride
  • PhenylMethyl Sulfonyl Fluoride, OMniPur(R)
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  • PhenylMethanesulfonyl fluoride, 99% 1GR
  • PHENYLMETHANESULFONYL FLUORIDE SOLUTION, 0.1 M IN ETHANOL*
  • PhenylMethylSulphonylFluoride>99%
  • Pmsf(PhenylmethylSulfonylFluoride)
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  • Phenylmethanesulphonyl fluoride 99%
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  • Phenylmethanesulfonyl fluoride, Phenylmethylsulfonyl fluoride, PMSF
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  • FLORISIL 100-200 U.S. MESH FR CHROMATOGR
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  • BCS ASSAY KIT
  • Phenylmethylsulfonyl fluoride≥ 99% (GC)
  • PHENYLMETHYLSUFONYL FLUORIDE
  • PHENYLMETHYLSULFONYL FLUORIDE
  • PHENYLMETHYLSULPHONYL FLUORIDE
  • PHENYLMETHANESULFONIC ACID FLUORIDE
  • PHENYLMETHANSULFOFLUORIDE
  • PHENYLMETHANESULFONYL FLUORIDE
  • PHENYLMETHANESULPHONYL FLUORIDE
  • TOSYL FLUORIDE
  • PHENYLMETHYLSULFONYL FLUORIDE;BENZYLSULFONYL FLUORIDE
  • OmniPur Phenylmethyl Sulfonyl Fluoride - CAS 329-98-6 - Calbiochem