tert-Butyl glycinate
- Product Name
- tert-Butyl glycinate
- CAS No.
- 6456-74-2
- Chemical Name
- tert-Butyl glycinate
- Synonyms
- tert-butyl 2-aminoacetate;Gly-OtBu;GLYCINE TERT-BUTYL ESTER;Gly-Otbu-OH;tert-Butyl glycite;Glycine tert-butyl;TERT-BUTYL GLYCINATE;GLYCINE T-BUTYL ESTER;tert-Butyl aminoacetate;GLYCIN-TERT-BUTYL ESTER
- CBNumber
- CB9455418
- Molecular Formula
- C6H13NO2
- Formula Weight
- 131.17
- MOL File
- 6456-74-2.mol
tert-Butyl glycinate Property
- Melting point:
- 148-150 °C (decomp)
- Boiling point:
- 29-31°C 2mm
- Density
- 0,96 g/cm3
- refractive index
- 1.4240
- Flash point:
- 29-31°C/2mm
- storage temp.
- Store at +2°C to +8°C.
- form
- liquid
- pka
- 7.36±0.29(Predicted)
- color
- colorless to pale yellow transparent
- Water Solubility
- Miscible with acetone and methanol. Slightly miscible with ehtanol. Immiscible with water.
- Sensitive
- Air Sensitive
- BRN
- 2039000
- CAS DataBase Reference
- 6456-74-2(CAS DataBase Reference)
Safety
- Risk Statements
- 36/38
- Safety Statements
- 26-36/37/39
- TSCA
- No
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T243442
- Product name
- TERT-BUTYL AMINOACETATE
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $113
- Updated
- 2025/07/31
- Product number
- B810023
- Product name
- tert-Butyl2-Aminoacetate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B810023
- Product name
- tert-Butyl2-Aminoacetate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 0034TG
- Product name
- tert-Butylglycinate,tech.
- Packaging
- 25g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 300080
- Product name
- Glycine tert-butyl ester, 99%
- Packaging
- 1g
- Price
- $49.5
- Updated
- 2021/12/16
tert-Butyl glycinate Chemical Properties,Usage,Production
Chemical Properties
The amino group in the structure of tert-butyl glycinate has a certain nucleophilicity and can undergo a series of nucleophilic substitution reactions, for example, it can be reacted with haloalkanes to obtain alkylated products. As a chemical intermediate, tert-butyl glycinate can be converted into a variety of organic compounds through a series of reactions, such as amino acids, peptides, heterocyclic compounds and so on. In the synthesis of amino acids, tert-butyl glycinate can be used as a starting material for the synthesis of other amino acids, and can be converted to the target product through nucleophilic substitution reaction, acylation reaction and other reactions.
Uses
Glycine tert-butyl ester is used in the preparation of Schiff base by reacting with benzophenone. The resultant Schiff base undergoes asymmetric alkylation with arylmethyl bromides in the presence of O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide as chiral phase transfer catalyst to give guanidine-containing pentacyclic compound.
Synthesis
1634-04-4
56-40-6
6456-74-2
10 mmol of glycine, 4 g of molecular sieves, and 20 mL of methyl tert-butyl ether were added to a 50 mL round-bottomed flask fitted with a septum, and the mixture was cooled to 25 °C. 30 mmol of sulfuric acid was slowly added dropwise to the solution using a syringe. The reaction was maintained at 25 °C for the indicated time as shown in Table 5. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into 25 mL of saturated aqueous sodium bicarbonate solution. The organic phase was separated and the aqueous phase was extracted twice with hexane. The organic phases were combined, washed with water and subsequently dried with anhydrous sodium sulfate. Finally, the solvent was removed by distillation to give tert-butyl glycinate.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 6, p. 641 - 645
tert-Butyl glycinate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl glycinate Suppliers
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View Lastest Price from tert-Butyl glycinate manufacturers
- Product
- tert-Butyl glycinate 6456-74-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Gly-Otbu 6456-74-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-24
- Product
- tert-Butyl glycinate 6456-74-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27