6-Chloro-2-fluoropurine

Product Name: 6-Chloro-2-fluoropurine
CAS No.: 1651-29-2
Chemical Name: 6-Chloro-2-fluoropurine
Synonyms: uoropurine;6-CHLORO-2-FLUORO;6-CHLORO-2-FLUORPURINE;2-fluoro-6-chloropurine;6-CHLORO-2-FLUOROPURINE;6-CHLORO-2-FLUORO-9H-PURINE;6-Chloro-2-fluoropurine >6-chloro-2-fluoro-7H-purine;6-chloro-2-fluoropurine 98%;9H-Purine, 6-chloro-2-fluoro-
CBNumber: CB9460810
Molecular Formula: C5H2ClFN4
Formula Weight: 172.55
MOL File: 1651-29-2.mol

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6-Chloro-2-fluoropurine Property

Melting point:: 162-163°C
Boiling point:: 221.8±50.0 °C(Predicted)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
pka: 4.88±0.20(Predicted)
form: powder to crystal
color: White to Light yellow to Green
InChI: InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
InChIKey: UNRIYCIDCQDGQE-UHFFFAOYSA-N
SMILES: N1C2C(=NC(F)=NC=2Cl)NC=1
CAS DataBase Reference: 1651-29-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22-37/39-26
Safety Statements: 26-36/37/39-39
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2221
Product name: 6-Chloro-2-fluoropurine
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $99
Updated: 2025/07/31

Cayman Chemical

Product number: 30481
Product name: 6-Chloro-2-fluoropurine
Packaging: 250mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 30481
Product name: 6-Chloro-2-fluoropurine
Packaging: 1g
Price: $72
Updated: 2024/03/01

Apolloscientific

Product number: PC408500
Product name: 6-Chloro-2-fluoro-7H-purine
Purity: 98%
Packaging: 10g
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC03333
Product name: 6-Chloro-2-fluoropurine
Packaging: 5G
Price: $55
Updated: 2021/12/16

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6-Chloro-2-fluoropurine Chemical Properties,Usage,Production

Description

6-Chloro-2-fluoropurine is a heterocyclic building block. It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro. 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.

Chemical Properties

Beige solid

Uses

6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2''-Fluoro-3''-Hydroxymethyl-5''-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2'',5'',5''-trifluoro-3''-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties.

Synthesis

10310-21-1

1651-29-2

General procedure for the synthesis of 6-chloro-2-fluoro-9H-purine from 2-amino-6-chloropurine: 0.3 M NaNO2 aqueous solution (200 mL, 60 mmol) was slowly added dropwise to a vigorously stirred suspension of 2-amino-6-chloro-9H-purine (6.0 g, 35.4 mmol) at -15 °C. Subsequently, 120 mL of 48% HBF4 aqueous solution (0.92 mol) was added over 75 min. The reaction mixture was stirred at room temperature and kept in a light yellow reaction solution state for 20 min. After cooling again to -15 °C, it was neutralized with 50% NaOH aqueous solution to pH=6.0. The water was removed by vacuum and the orange solid obtained was purified by silica gel column chromatography (eluent ratio 90:10 dichloromethane to methanol, Rf value 0.50). 6-Chloro-2-fluoro-9H-purine was finally obtained as a white solid (3.0 g, 49.1% yield).

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 14, p. 3887 - 3894
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1746 - 1767
[3] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1161 - 1164
[4] Patent: US2002/68721, 2002, A1
[5] Patent: WO2004/16612, 2004, A2. Location in patent: Page 54

6-Chloro-2-fluoropurine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-2-fluoropurine Suppliers

Americas 1 Belgium 1 Canada 2 China 187 Europe 3 Germany 5 India 12 Japan 3 Switzerland 2 Ukraine 1 United Kingdom 17 United States 52 Global 286

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Capot Chemical Co., Ltd

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View Lastest Price from 6-Chloro-2-fluoropurine manufacturers

Henan Research New Materials Co., Ltd.

Product: 6-Chloro-2-fluoropurine 1651-29-2
Price: US $0.00/Kg
Min. Order: 50Kg
Purity: 98％
Supply Ability: 100kg
Release date: 2025-04-12

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Chloro-2-fluoropurine 1651-29-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Henan Fengda Chemical Co., Ltd

Product: 6-Chloro-2-fluoropurine 1651-29-2
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

1651-29-2, 6-Chloro-2-fluoropurineRelated Search:

6-Chloropurine Cyhalothrin Purine Flucloxacillin sodium Fluroxypyr Flucloxacillin λ-Cyhalothrin Fluorine Difluorochloromethane 2-Fluoropurine 2-FLUOROPYRIMIDINE 6-Chloro-2-fluoropurine

6-CHLORO-2-FLUORO-9H-PURINE

6-CHLORO-2-FLUOROPURINE

6-CHLORO-2-FLUORPURINE

2-fluoro-6-chloropurine

6-Chloro-2-fluoro-7H-purine 98%

6-CHLORO-2-FLUORO

6-chloro-2-fluoro-7H-purine

6-Chloro-2-fluoropurine &gt

uoropurine

9H-Purine, 6-chloro-2-fluoro-

6-chloro-2-fluoropurine 98%

1651-29-2

1654-29-2

C5H2N4ClF

C5H2FClN4

C5H2ClFN4

Heterocyclic Building Blocks

PurinesHeterocyclic Building Blocks

Thiazoles

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Fused Ring Systems

Building Blocks

Halogenated Heterocycles

Halides

Purine

Purines