6-Chloro-2-fluoropurine
- Product Name
- 6-Chloro-2-fluoropurine
- CAS No.
- 1651-29-2
- Chemical Name
- 6-Chloro-2-fluoropurine
- Synonyms
- uoropurine;6-CHLORO-2-FLUORO;6-CHLORO-2-FLUORPURINE;2-fluoro-6-chloropurine;6-CHLORO-2-FLUOROPURINE;6-CHLORO-2-FLUORO-9H-PURINE;6-Chloro-2-fluoropurine >6-chloro-2-fluoro-7H-purine;6-chloro-2-fluoropurine 98%;9H-Purine, 6-chloro-2-fluoro-
- CBNumber
- CB9460810
- Molecular Formula
- C5H2ClFN4
- Formula Weight
- 172.55
- MOL File
- 1651-29-2.mol
6-Chloro-2-fluoropurine Property
- Melting point:
- 162-163°C
- Boiling point:
- 221.8±50.0 °C(Predicted)
- Density
- 1.98±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
- pka
- 4.88±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Green
- InChI
- InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
- InChIKey
- UNRIYCIDCQDGQE-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(F)=NC=2Cl)NC=1
- CAS DataBase Reference
- 1651-29-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22-37/39-26
- Safety Statements
- 26-36/37/39-39
- WGK Germany
- 3
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2221
- Product name
- 6-Chloro-2-fluoropurine
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $99
- Updated
- 2025/07/31
- Product number
- 30481
- Product name
- 6-Chloro-2-fluoropurine
- Packaging
- 250mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 30481
- Product name
- 6-Chloro-2-fluoropurine
- Packaging
- 1g
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 3H31-7-69
- Product name
- 6-Chloro-2-fluoro-7H-purine
- Packaging
- 10g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- FC03333
- Product name
- 6-Chloro-2-fluoropurine
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
6-Chloro-2-fluoropurine Chemical Properties,Usage,Production
Description
6-Chloro-2-fluoropurine is a heterocyclic building block. It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro. 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.
Chemical Properties
Beige solid
Uses
6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2''-Fluoro-3''-Hydroxymethyl-5''-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2'',5'',5''-trifluoro-3''-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties.
Synthesis
10310-21-1
1651-29-2
General procedure for the synthesis of 6-chloro-2-fluoro-9H-purine from 2-amino-6-chloropurine: 0.3 M NaNO2 aqueous solution (200 mL, 60 mmol) was slowly added dropwise to a vigorously stirred suspension of 2-amino-6-chloro-9H-purine (6.0 g, 35.4 mmol) at -15 °C. Subsequently, 120 mL of 48% HBF4 aqueous solution (0.92 mol) was added over 75 min. The reaction mixture was stirred at room temperature and kept in a light yellow reaction solution state for 20 min. After cooling again to -15 °C, it was neutralized with 50% NaOH aqueous solution to pH=6.0. The water was removed by vacuum and the orange solid obtained was purified by silica gel column chromatography (eluent ratio 90:10 dichloromethane to methanol, Rf value 0.50). 6-Chloro-2-fluoro-9H-purine was finally obtained as a white solid (3.0 g, 49.1% yield).
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 14, p. 3887 - 3894
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1746 - 1767
[3] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1161 - 1164
[4] Patent: US2002/68721, 2002, A1
[5] Patent: WO2004/16612, 2004, A2. Location in patent: Page 54
6-Chloro-2-fluoropurine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-2-fluoropurine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 6-Chloro-2-fluoropurine manufacturers
- Product
- 6-Chloro-2-fluoropurine 1651-29-2
- Price
- US $0.00/Kg
- Min. Order
- 50Kg
- Purity
- 98％
- Supply Ability
- 100kg
- Release date
- 2025-04-12
- Product
- 6-Chloro-2-fluoropurine 1651-29-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 6-Chloro-2-fluoropurine 1651-29-2
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11