ChemicalBook > CAS DataBase List > 6-Chloro-2-fluoropurine

6-Chloro-2-fluoropurine

Product Name
6-Chloro-2-fluoropurine
CAS No.
1651-29-2
Chemical Name
6-Chloro-2-fluoropurine
Synonyms
uoropurine;6-CHLORO-2-FLUORO;6-CHLORO-2-FLUORPURINE;2-fluoro-6-chloropurine;6-CHLORO-2-FLUOROPURINE;6-CHLORO-2-FLUORO-9H-PURINE;6-Chloro-2-fluoropurine >6-chloro-2-fluoro-7H-purine;6-chloro-2-fluoropurine 98%;9H-Purine, 6-chloro-2-fluoro-
CBNumber
CB9460810
Molecular Formula
C5H2ClFN4
Formula Weight
172.55
MOL File
1651-29-2.mol
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6-Chloro-2-fluoropurine Property

Melting point:
162-163°C
Boiling point:
221.8±50.0 °C(Predicted)
Density 
1.98±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
pka
4.88±0.20(Predicted)
form 
powder to crystal
color 
White to Light yellow to Green
InChI
InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
InChIKey
UNRIYCIDCQDGQE-UHFFFAOYSA-N
SMILES
N1C2C(=NC(F)=NC=2Cl)NC=1
CAS DataBase Reference
1651-29-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22-37/39-26
Safety Statements 
26-36/37/39-39
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2221
Product name
6-Chloro-2-fluoropurine
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$99
Updated
2025/07/31
Cayman Chemical
Product number
30481
Product name
6-Chloro-2-fluoropurine
Packaging
250mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30481
Product name
6-Chloro-2-fluoropurine
Packaging
1g
Price
$72
Updated
2024/03/01
SynQuest Laboratories
Product number
3H31-7-69
Product name
6-Chloro-2-fluoro-7H-purine
Packaging
10g
Price
$79
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC03333
Product name
6-Chloro-2-fluoropurine
Packaging
10g
Price
$90
Updated
2021/12/16
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6-Chloro-2-fluoropurine Chemical Properties,Usage,Production

Description

6-Chloro-2-fluoropurine is a heterocyclic building block. It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro. 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.

Chemical Properties

Beige solid

Uses

6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2''-Fluoro-3''-Hydroxymethyl-5''-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2'',5'',5''-trifluoro-3''-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties.

Synthesis

10310-21-1

1651-29-2

General procedure for the synthesis of 6-chloro-2-fluoro-9H-purine from 2-amino-6-chloropurine: 0.3 M NaNO2 aqueous solution (200 mL, 60 mmol) was slowly added dropwise to a vigorously stirred suspension of 2-amino-6-chloro-9H-purine (6.0 g, 35.4 mmol) at -15 °C. Subsequently, 120 mL of 48% HBF4 aqueous solution (0.92 mol) was added over 75 min. The reaction mixture was stirred at room temperature and kept in a light yellow reaction solution state for 20 min. After cooling again to -15 °C, it was neutralized with 50% NaOH aqueous solution to pH=6.0. The water was removed by vacuum and the orange solid obtained was purified by silica gel column chromatography (eluent ratio 90:10 dichloromethane to methanol, Rf value 0.50). 6-Chloro-2-fluoro-9H-purine was finally obtained as a white solid (3.0 g, 49.1% yield).

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 14, p. 3887 - 3894
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1746 - 1767
[3] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1161 - 1164
[4] Patent: US2002/68721, 2002, A1
[5] Patent: WO2004/16612, 2004, A2. Location in patent: Page 54

6-Chloro-2-fluoropurine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-2-fluoropurine Suppliers

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View Lastest Price from 6-Chloro-2-fluoropurine manufacturers

Henan Research New Materials Co., Ltd.
Product
6-Chloro-2-fluoropurine 1651-29-2
Price
US $0.00/Kg
Min. Order
50Kg
Purity
98％
Supply Ability
100kg
Release date
2025-04-12
Henan Aochuang Chemical Co.,Ltd.
Product
6-Chloro-2-fluoropurine 1651-29-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Henan Fengda Chemical Co., Ltd
Product
6-Chloro-2-fluoropurine 1651-29-2
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11

1651-29-2, 6-Chloro-2-fluoropurineRelated Search:

6-Chloropurine Cyhalothrin Purine Flucloxacillin sodium Fluroxypyr Flucloxacillin λ-Cyhalothrin Fluorine Difluorochloromethane 2-Fluoropurine 2-FLUOROPYRIMIDINE 6-Chloro-2-fluoropurine

  • 6-CHLORO-2-FLUORO-9H-PURINE
  • 6-CHLORO-2-FLUOROPURINE
  • 6-CHLORO-2-FLUORPURINE
  • 2-fluoro-6-chloropurine
  • 6-Chloro-2-fluoro-7H-purine 98%
  • 6-CHLORO-2-FLUORO
  • 6-chloro-2-fluoro-7H-purine
  • 6-Chloro-2-fluoropurine &gt
  • uoropurine
  • 9H-Purine, 6-chloro-2-fluoro-
  • 6-chloro-2-fluoropurine 98%
  • 1651-29-2
  • 1654-29-2
  • C5H2N4ClF
  • C5H2FClN4
  • C5H2ClFN4
  • Heterocyclic Building Blocks
  • PurinesHeterocyclic Building Blocks
  • Thiazoles
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Fused Ring Systems
  • Building Blocks
  • Halogenated Heterocycles
  • Halides
  • Purine
  • Purines