ChemicalBook > CAS DataBase List > Eosin Disodium

Eosin Disodium

Product Name
Eosin Disodium
CAS No.
17372-87-1
Chemical Name
Eosin Disodium
Synonyms
Acid Red 87;Esoin Y;Eosin Y Na;AMI-5;RED 22;eosina;RED 21 LAKE;EOSIN Y DISODIUM;May-Grünwald Stain;MAY-GRUNWALD STAIN
CBNumber
CB9461211
Molecular Formula
C20H6Br4Na2O5
Formula Weight
691.85418
MOL File
17372-87-1.mol
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Eosin Disodium Property

Melting point:
>300°C
Density 
1.02 g/mL at 20 °C
vapor pressure 
0Pa at 25℃
Flash point:
11 °C
storage temp. 
Store at RT.
solubility 
H2O: 0.1 g/mL, dark red
Colour Index 
45380
form 
Solid
pka
2.9, 4.5(at 25℃)
color 
Reddish
PH Range
0(yellow)-3(green fluoresc.)
PH
9.2 (10g/l, H2O, 20℃)
Water Solubility 
freely soluble
λmax
514nm
Merck 
14,3603
BRN 
3586809
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Treating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials
Major Application
Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters
LogP
-1.33
CAS DataBase Reference
17372-87-1(CAS DataBase Reference)
EPA Substance Registry System
Eosin Yellowish (YS) (17372-87-1)
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Safety

Hazard Codes 
F,T,Xn,Xi
Risk Statements 
11-23/24/25-39/23/24/25-52/53-41-22-36-10
Safety Statements 
7-16-36/37-45-24/25-61-39-26
RIDADR 
UN 1230 3/PG 2
WGK Germany 
1
RTECS 
LM5850000
TSCA 
Yes
HS Code 
32041200
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
318906
Product name
Eosin Y solution
Purity
5wt. % in H
Packaging
500ml
Price
$98.2
Updated
2024/03/01
Sigma-Aldrich
Product number
205435
Product name
May-Grünwald Stain
Packaging
25g
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
1.15935
Product name
Eosin Y (yellowish) (C.I. 45380)
Purity
for microscopy Certistain?
Packaging
100g
Price
$400
Updated
2023/06/20
Sigma-Aldrich
Product number
200-M
Product name
Eosin Y Powder
Packaging
25g
Price
$100
Updated
2023/01/07
Sigma-Aldrich
Product number
200-M
Product name
Eosin Y Powder
Packaging
100g
Price
$187
Updated
2023/01/07
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Eosin Disodium Chemical Properties,Usage,Production

Chemical Properties

brownish-red powder

Uses

Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.

Uses

Anti Septic

Uses

Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.

Preparation

countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.

Definition

ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.

Flammability and Explosibility

Not classified

Biological Activity

ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.

in vitro

ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].

IC 50

0.78 and 1.41 μm for hmt1p and prmt1, respectively

storage

+4°C

Purification Methods

Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]

Properties and Applications

yellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.

Standard Light Fastness Soaping Persperation Fastness Oxygen bleaching Fastness to seawater
Fading Stain Fading Stain Fading Stain
ISO 2 3 3 2 1 2 2 2
AATCC 1 2 2 3 1 1 3 3

References

[1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62.

Eosin Disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Eosin Disodium Suppliers

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View Lastest Price from Eosin Disodium manufacturers

Hebei Longbang Technology Co., Ltd
Product
EOSIN 17372-87-1
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-27
HebeiShuoshengImportandExportco.,Ltd
Product
EOSIN 17372-87-1
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-05
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Eosin Y disodium salt 17372-87-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000kg/month
Release date
2021-07-28

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