ML414(NGI-1)

Product Name: ML414(NGI-1)
CAS No.: 790702-57-7
Chemical Name: ML414(NGI-1)
Synonyms: NGI-1;ML414;NGI1 NEW;ML414(NGI-1);NGI-1 (ML414);NGI-1 >=95% (HPLC);ML-414;ML414;NGI 1;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;ML 414,inhibit,Inhibitor,NGI 1,ML-414,NGI-1,Virus Protease,NGI1;5-(N,N-Dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
CBNumber: CB94664139
Molecular Formula: C17H22N4O3S2
Formula Weight: 394.51
MOL File: 790702-57-7.mol

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ML414(NGI-1) Property

Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 5 mg/ml)
form: powder
pka: 7.48±0.50(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1620
Product name: NGI-1
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1620
Product name: NGI-1
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $261
Updated: 2024/03/01

Tocris

Product number: 6652
Product name: NGI1
Purity: ≥98%(HPLC)
Packaging: 25
Price: $181
Updated: 2021/12/16

Tocris

Product number: 6652
Product name: NGI1
Purity: ≥98%(HPLC)
Packaging: 5
Price: $78
Updated: 2021/12/16

TRC

Product number: D477148
Product name: 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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ML414(NGI-1) Chemical Properties,Usage,Production

Description

NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.

storage

Store at +4°C

References

1) Lopez-Sambrooks et al. (2016), Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells; Nature Chem. Biol. 12 1023 2) Puschnik et al. (2017), A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity; Cell Rep. 21 3032 3) Lopez-Sambrooks et al. (2018), Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors; Cancer Res. July 19, 2018 Epub ahead of print 4) Baro et al. (2018), Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity; Clin. Cancer Res. July 2, 2018 Epub ahead of print

ML414(NGI-1) Preparation Products And Raw materials

Raw materials

Preparation Products

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ML414(NGI-1) Suppliers

China 50 India 1 United Kingdom 2 United States 6 Global 59

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790702-57-7, ML414(NGI-1)Related Search:

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ML414(NGI-1)

ML414

NGI-1

NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、

NGI-1 (ML414)

5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide

ML-414;ML414;NGI 1

NGI1 NEW

5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide

Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-

NGI-1 >=95% (HPLC)

<br>5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benz amide

5-(N,N-Dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide

ML 414,inhibit,Inhibitor,NGI 1,ML-414,NGI-1,Virus Protease,NGI1

790702-57-7

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