Food flavorings Content Analysis Toxicity Limited use
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Vanillylacetone

Food flavorings Content Analysis Toxicity Limited use
Product Name
Vanillylacetone
CAS No.
122-48-5
Chemical Name
Vanillylacetone
Synonyms
ZINGERONE;4-(4-HYDROXY-3-METHOXYPHENYL)BUTAN-2-ONE;ZINGIBERONE;Gingerone;Zingarone;FEMA 3124;NSC 15335;zingherone;[0]-Paradol;(0)-paradol
CBNumber
CB9479326
Molecular Formula
C11H14O3
Formula Weight
194.23
MOL File
122-48-5.mol
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Vanillylacetone Property

Melting point:
40-41 °C(lit.)
Boiling point:
141 °C0.5 mm Hg(lit.)
Density 
1.14 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.541(lit.)
FEMA 
3124 | ZINGERONE
Flash point:
>230 °F
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.03±0.20(Predicted)
color 
White to Pale Yellow
Odor
at 100.00 %. sweet spicy phenolic ginger vanilla woody
Odor Type
spicy
Merck 
14,10166
JECFA Number
730
InChIKey
OJYLAHXKWMRDGS-UHFFFAOYSA-N
LogP
0.64
CAS DataBase Reference
122-48-5(CAS DataBase Reference)
NIST Chemistry Reference
2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)-(122-48-5)
EPA Substance Registry System
2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)- (122-48-5)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
EL8900000
TSCA 
Yes
HS Code 
29333999
Hazardous Substances Data
122-48-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W312420
Product name
Vanillylacetone
Purity
≥98%, natural (US), FG
Packaging
100g
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
W312401
Product name
Vanillylacetone
Purity
≥96%, FG
Packaging
sample
Price
$54.6
Updated
2024/03/01
Sigma-Aldrich
Product number
W312420
Product name
Vanillylacetone
Purity
≥98%, natural (US), FG
Packaging
500g
Price
$576
Updated
2024/03/01
Sigma-Aldrich
Product number
88787
Product name
Vanillylacetone
Purity
analytical reference material
Packaging
50mg
Price
$97.3
Updated
2024/03/01
TCI Chemical
Product number
H1314
Product name
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
Purity
>98.0%(GC)
Packaging
25g
Price
$72
Updated
2024/03/01
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Vanillylacetone Chemical Properties,Usage,Production

Food flavorings

Vanillylacetone also called zingerone , is a food spice which is allowed to be prepared   appropriately according to production needs by Chinese "Sanitary Standards of Using Food Additives" (GB 2760-1996),its chemical name is 4-(4-hydroxy 3-methoxyphenyl)-2-butanone. Yellow or light amber crystal (acetone, petroleum ether or ethyl ether-petroleum ether), at room temperature, after long time ,it becomes to a viscous liquid.It  has a strong irritating odor like spicy ginger and ginger-like pungent taste,it has a sweet, spicy, full-bodied and deep floral aroma, fragrance lasts for a long time. The relative density is 1.138~1.139 (25 ℃), melting point 40~41 ℃, boiling point 290 ℃ (102 ℃), refractive index 1.544~1.545. It  can be dissolved in 50% ethanol in 1:1 ratio , slightly soluble in water and petroleum ether, soluble in dilute alkali. In the steam it slowly evaporates. When heated ,it can deoxidate silver nitrate ammonia solution; and it can react with an alcohol solution of ferric chloride to turn to green. It is derived from the Zingiber officinale essential oils , Vanillylacetone is the main constituent of ginger oil . After the condensation reaction of vanillin and acetone,it is obtained through hydrogenation .it is used as a full-bodied flavor sweeteners and edible flavorings. In the perfumed products ,it can have a "leather", "tobacco" flavor. It is not easy to change color.
Vanillylacetone can be used in the formulation of flavors, it is mainly used as sweeteners for rich aromas and flavors , in very small quantities, the application range is very small. IFRA has no restrictions.
Vanillylacetone is recognized as GRAS by FEMA , FEMA number is 3124, and it is  approved by the FDA for human consumption,it is included in the artificial flavor table by the Council of Europe in the level of 15mg/kg dosage which can be used in foods and is not harmful to human health . Vanillylacetone can be used for food flavor and seasoning product formulations.
FEMA provides: Vanillylacetone highest reference amount is  soft drinks, 6.9mg/kg; ice cream, ices, 7.8mg/kg; candy, 11mg/kg; baked goods, 11mg/kg; chewing gum, 15mg/kg.

Content Analysis

Use gas chromatography (GT-10-4) nonpolar column method for the determination.

Toxicity

GRAS (FEMA).
LD502.58g/kg (rat, dictation).

Limited use

FEMA (mg/kg): Soft drinks 6.9; cold:7.8 ; confectionery, bakery products, 11.0; Chewing Gum:15.0
FDA, §172.515: the right amount limit.

Chemical Properties

Zingerone has a strong, pungent odor reminiscent of ginger. It has a sharp taste, similar to ginger.

Chemical Properties

White solid. Soluble in ether; sparingly soluble in water and petroleum ether.

Occurrence

Reported found in the essential oil of Zingiber officinale. Also reported found in cranberry, raspberry, ginger and mango.

Uses

Vanillylacetone is a phenolic compound that naturally occurs in cranberry and ginger. Studies shows that Vanillylacetone exhibits variable cytotoxic, cytoprotective and antioxidant activity against liver and human tumor cells. Vanillylacetone is also used in herbal medicine for various purposes.

Uses

In fragrances, flavors and cosmetics; in artificial spice oils.

Definition

ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.

Preparation

By condensation of vanillin with acetone followed by hydrogenation.

Aroma threshold values

Aroma characteristics at 10.0%: low impacting, creamy, spicy eugenol clove-like with a slight balsamic vanilla-like note.

Taste threshold values

Taste characteristics at 80 ppm: spicy with a biting, lingering heat. Taste characteristics at 20 ppm in 5% sugar solution: smooth, sweet, creamy and warm, spicy clove with a slight lingering burning bite.

Safety Profile

Moderately toxic by ingestion. A skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Vanillylacetone Preparation Products And Raw materials

Raw materials

Preparation Products

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Vanillylacetone Suppliers

Nanjing Duolong Bio-tech Co.,Ltd.
Tel
18905173768
Fax
025-83263139
Email
sales@dolonchem.com
Country
China
ProdList
2331
Advantage
50
Hubei Lingyan Biotechnology Co., Ltd
Tel
027-59304846 13297025796
Email
2331003879@qq.com
Country
China
ProdList
60
Advantage
58
Wuhan kemike Biomedical Technology Co., Ltd
Tel
13163388153 13163388153
Email
yeqiu416@163.com
Country
China
ProdList
9910
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Vanillylacetone manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Vanillylacetone 122-48-5
Price
US $1000.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
Hebei Chuanghai Biotechnology Co,.LTD
Product
Vanillylacetone 122-48-5
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-20
JINING XINHE CHEMICAL CO., LTD
Product
Vanillylacetone 122-48-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10ton
Release date
2024-07-20

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