ChemicalBook > CAS DataBase List > 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt

Product Name
2'-Deoxyuridine 5'-monophosphate disodium salt
CAS No.
42155-08-8
Chemical Name
2'-Deoxyuridine 5'-monophosphate disodium salt
Synonyms
dump;DUMP 2NA;2'-dUMP?2Na;dUMP·（Na·salt）;D-UMP DISODIUM SALT;Diquafosol Impurity 22;Diquafosol Impurity 30;dUMP 100mM Sodium Solution;2'-Deoxyuridine 5'-monophosphate;2'-Deoxy-5'-uridylic acid disodium salt
CBNumber
CB9482517
Molecular Formula
C9H14N2NaO8P
Formula Weight
332.18
MOL File
42155-08-8.mol
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2'-Deoxyuridine 5'-monophosphate disodium salt Property

storage temp. 
-20°C
solubility 
PBS (pH 7.2): 1 mg/ml
form 
Powder
color 
White to Off-white
Water Solubility 
Soluble in water.
CAS DataBase Reference
42155-08-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3876
Product name
2′-Deoxyuridine 5′-monophosphate disodium salt
Purity
Sigma Grade
Packaging
100mg
Price
$256
Updated
2024/03/01
Sigma-Aldrich
Product number
D3876
Product name
2′-Deoxyuridine 5′-monophosphate disodium salt
Purity
Sigma Grade
Packaging
1g
Price
$1490
Updated
2024/03/01
Alfa Aesar
Product number
J64627
Product name
2'-Deoxyuridine-5'-monophosphate disodium salt, 99%
Packaging
250mg
Price
$110
Updated
2024/03/01
Alfa Aesar
Product number
J64627
Product name
2'-Deoxyuridine-5'-monophosphate disodium salt, 99%
Packaging
1g
Price
$237
Updated
2024/03/01
Sigma-Aldrich
Product number
D3876
Product name
2′-Deoxyuridine 5′-monophosphate disodium salt
Purity
Sigma Grade
Packaging
250mg
Price
$487
Updated
2024/03/01
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2'-Deoxyuridine 5'-monophosphate disodium salt Chemical Properties,Usage,Production

Description

2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus.

Uses

2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

General Description

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

Biochem/physiol Actions

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

2'-Deoxyuridine 5'-monophosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxyuridine 5'-monophosphate disodium salt Suppliers

China 144 Germany 1 India 5 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 21 Global 178
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View Lastest Price from 2'-Deoxyuridine 5'-monophosphate disodium salt manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd
Product
2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP-Na2) 42155-08-8
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥99.0%
Supply Ability
500 kg
Release date
2024-02-07
Henan Aochuang Chemical Co.,Ltd.
Product
2'-Deoxyuridine 5'-monophosphate disodium salt 42155-08-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Shaanxi Dideu Medichem Co. Ltd
Product
2'-Deoxyuridine 5'-monophosphate disodium salt 42155-08-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14

42155-08-8, 2'-Deoxyuridine 5'-monophosphate disodium saltRelated Search:

Thymidine-5'-monophosphate disodium salt Sodium Phosphate, Dibasic Pamidronate disodium salt Ethylenediaminetetraacetic acid disodium salt Broxuridine Floxuridine Clodronate disodium Uridine 2'-Deoxyuridine Sodium Monofluorophosphate Disodium 5'-dGMP 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Uridine 5′-monophosphate disodium salt 5-BROMO-2''-DEOXYURIDINE-5''-MONOPHOSPHATE DISODIUM SALT URIDYLIC ACID Uracil THYMIDINE 5'-MONOPHOSPHATE, [2-14C] DISODIUM SALT [5',5''-2H2]URIDINE 5'-MONOPHOSPHATE DISODIUM SALT

  • dump
  • 2''-Deoxyuridine-5''-monophosphoric acid disodium salt
  • 2'-deoxyuridine 5'-monophosphate*disodium sigma G
  • 5'-Uridylic acid, 2'-deoxy-, disodium salt
  • 2'-Deoxyuridine-5'-monophosphate,sodiumsalt
  • 2'-DEOXYURIDINE 5'-MONOPHOSPHATEDISODIUM SIGMA GRA
  • 2''-DEOXYURIDINE 5''-MONOPHOSPHATE DISODIUM SALT (DUMP-NA2)
  • 2'-Deoxy-5'-uridylic acid disodium salt
  • 2'-Deoxyuridine 5'-(phosphoric acid disodium) salt
  • Sodium ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate
  • 2'-DEOXYURIDINE 5'-MONOPHOSPHATE DISODIUM SALT
  • dUMP, 2'-Deoxyuridine-5'-Monophosphate, disodiuM salt
  • DUMP 2NA
  • D-UMP DISODIUM SALT
  • 2'-dUMP?2Na
  • dUMP·（Na·salt）
  • 2′-Deoxyuridine5′-mono-phos-phatedisodiumsal
  • 2'-Deoxyuridine 5'-monophosphate (disodium)
  • Diquafosol Impurity 22
  • [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • 2`-Deoxyuridine-5`-Monophosphate Disodium Salt (dUMP-Na2) extrapure, 98%
  • 2′-Deoxyuridine-5′-monophosphate disodium salt [dUMP·(Na·salt)
  • Deoxyuridine 5′-monophosphate (sodium salt)
  • Diquafosol Impurity 30
  • Disodium 2'-deoxy-5'-O-phosphonatouridine
  • dUMP 100mM Sodium Solution
  • 2'-Deoxyuridine 5'-monophosphate
  • 2'-Deoxyuridine 5'-monophosphate disodium salt
  • 42155-08-8
  • C9H11N2Na2O8P
  • C9H11N2O8PNa2
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Metabolic Pathways
  • Nucleotide
  • Metabolomics
  • BioChemical
  • Nucleotide