COMBRETASTATIN A-4

ChemicalBook > CAS DataBase List > COMBRETASTATIN A-4

Product Name: COMBRETASTATIN A-4
CAS No.: 117048-59-6
Chemical Name: COMBRETASTATIN A-4
Synonyms: CA4;CS-A4;CS-284;CRC 87-09;NSC 817373;NSC-817373;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4
CBNumber: CB9496826
Molecular Formula: C18H20O5
Formula Weight: 316.35
MOL File: 117048-59-6.mol

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COMBRETASTATIN A-4 Property

Melting point:: 84.5-85.5°C
Boiling point:: 490.3±45.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL
pka: 9.65±0.10(Predicted)
form: powder
color: off-white
Merck: 14,2494

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-41
Safety Statements: 26-36/37-39-45
RIDADR: UN 2811
WGK Germany: 2
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29095000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7744
Product name: Combretastatin A4
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $70.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 234200
Product name: Combretastatin A-4
Packaging: 10mg
Price: $230
Updated: 2024/03/01

TCI Chemical

Product number: C2520
Product name: Combretastatin A4
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: C2520
Product name: Combretastatin A4
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $812
Updated: 2024/03/01

Cayman Chemical

Product number: 10007412
Product name: Combrestatin A4
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

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COMBRETASTATIN A-4 Chemical Properties,Usage,Production

Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC₅₀ values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC₅₀ value of 2.2 μM.

Chemical Properties

Crystalline Powder

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Uses

Combretastatin A4 has been used:

as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae

Definition

ChEBI: Combretastatin A4 is a stilbenoid.

General Description

Combretastatin A4 belong to the class of colchicinoids compounds.

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

Biochem/physiol Actions

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

Anticancer Research

It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).

COMBRETASTATIN A-4 Preparation Products And Raw materials

Raw materials

Isovanillin Copper Quinoline Acetic anhydride Triethylamine 3,4,5-Trimethoxyphenylacetic acid Hydrochloric acid

Preparation Products

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COMBRETASTATIN A-4 Suppliers

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View Lastest Price from COMBRETASTATIN A-4 manufacturers

PNP Biotech Co. Ltd

Product: Combretastatin A4 117048-59-6
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-10-25

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Combretastatin A4 117048-59-6 117048-59-6
Price: US $17.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

Baoji Guokang Healthchem co.,ltd

Product: Combretastatin A4 117048-59-6
Price: US $390.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1kg
Release date: 2021-06-07

117048-59-6, COMBRETASTATIN A-4Related Search:

2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Hydroxyecdysone Artemether beta-Sitosterol alpha-Terpineol hydroxygenkwanin MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one 4-Hydroxyphenethyl alcohol Combretastatin A4 phosphate disodium salt COMBRETASTATIN A-4 COMBRETASTATIN A1 (Z)-3-Ethoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol BENZENEACETIC ACID, 3-HYDROXY-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)- 2,3-DIMETHOXY-5-[(Z)-2-(4-METHOXY-3-(2-[2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-4-YL)OXY)ETHOXY]ETHOXY)PHENYL)ETHENYL]PHENYL METHYL ETHER Combretastatin A-1 di-O-phosphate tetra-sodium salt 3-(3-Hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-acrylic acid

Combretastatin A4 117048-59-6

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

CS-284

CRC 87-09

2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z

(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4

Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )

(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%

2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol

3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol

5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol

Combretastatin A4

(Z)-CombretastatinA4

combretastatin A-4 (CA-4)

2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol

Combrestatin A4

(Z)-2-Methoxy-5-[2-(3,4,5-triMethoxyphenyl)ethenyl]phenol, 3,4,5-TriMethoxy-3'-hydroxy-4'-Methoxy-(Z)-stilbene

CS-A4

CoMbretastatin A

CA-4, Combretastatin A-4

1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene

CA4

(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol

2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol

(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol

Combretastatin A4 (CRC 87-09)

Combretastatin A4 &gt

Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-

Recombinant Human Carbonic Anhydrase IV/CA4 Protein, His Tag

3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene

Combretastatin TXB-4

NSC 817373

NSC-817373

117048-59-6

17048-59-6

API

Anti-cancer & immunity

Inhibitors

Combretastatin