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COMBRETASTATIN A-4

Product Name
COMBRETASTATIN A-4
CAS No.
117048-59-6
Chemical Name
COMBRETASTATIN A-4
Synonyms
CA4;CS-A4;CS-284;CRC 87-09;NSC 817373;NSC-817373;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4
CBNumber
CB9496826
Molecular Formula
C18H20O5
Formula Weight
316.35
MOL File
117048-59-6.mol
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COMBRETASTATIN A-4 Property

Melting point:
84.5-85.5°C
Boiling point:
490.3±45.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
pka
9.65±0.10(Predicted)
form 
powder
color 
off-white
Merck 
14,2494
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-41
Safety Statements 
26-36/37-39-45
RIDADR 
UN 2811
WGK Germany 
2
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
29095000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7744
Product name
Combretastatin A4
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$70.2
Updated
2024/03/01
Sigma-Aldrich
Product number
234200
Product name
Combretastatin A-4
Packaging
10mg
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
C2520
Product name
Combretastatin A4
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
C2520
Product name
Combretastatin A4
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$812
Updated
2024/03/01
Cayman Chemical
Product number
10007412
Product name
Combrestatin A4
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
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COMBRETASTATIN A-4 Chemical Properties,Usage,Production

Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.

Chemical Properties

Crystalline Powder

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Uses

Combretastatin A4 has been used:

  • as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
  • to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
  • as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae

Definition

ChEBI: Combretastatin A4 is a stilbenoid.

General Description

Combretastatin A4 belong to the class of colchicinoids compounds.

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

Biochem/physiol Actions

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

Anticancer Research

It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).

COMBRETASTATIN A-4 Preparation Products And Raw materials

Raw materials

Isovanillin Copper Quinoline Acetic anhydride Triethylamine 3,4,5-Trimethoxyphenylacetic acid Hydrochloric acid

Preparation Products

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COMBRETASTATIN A-4 Suppliers

Americas 1 Canada 1 China 245 Europe 1 Germany 6 India 6 Japan 1 The Netherlands 1 United Kingdom 4 United States 31 Global 297
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62
Toroma Organics Ltd
Tel
--
Fax
--
Country
Germany
ProdList
223
Advantage
58
ENDOTHERM GmbH
Tel
--
Fax
--
Email
dr.kattner@endotherm.de
Country
Germany
ProdList
78
Advantage
42
ENDOTHERM GmbH
Tel
--
Fax
--
Email
info@endotherm.de
Country
Germany
ProdList
375
Advantage
30
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from COMBRETASTATIN A-4 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
COMBRETASTATIN A-4 117048-59-6
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-08-24
PNP Biotech Co. Ltd
Product
Combretastatin A4 117048-59-6
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2022-10-25
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Combretastatin A4 117048-59-6 117048-59-6
Price
US $17.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-09

117048-59-6, COMBRETASTATIN A-4Related Search:

2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Hydroxyecdysone Artemether beta-Sitosterol alpha-Terpineol hydroxygenkwanin MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one 4-Hydroxyphenethyl alcohol Combretastatin A4 phosphate disodium salt COMBRETASTATIN A-4 COMBRETASTATIN A1 (Z)-3-Ethoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol BENZENEACETIC ACID, 3-HYDROXY-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)- 2,3-DIMETHOXY-5-[(Z)-2-(4-METHOXY-3-(2-[2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-4-YL)OXY)ETHOXY]ETHOXY)PHENYL)ETHENYL]PHENYL METHYL ETHER Combretastatin A-1 di-O-phosphate tetra-sodium salt 3-(3-Hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-acrylic acid

  • Combretastatin A4 117048-59-6
  • Combretastatin A-4 - CAS 117048-59-6 - Calbiochem
  • CS-284
  • CRC 87-09
  • 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z
  • (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
  • Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%
  • 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
  • 3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol
  • 5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol
  • Combretastatin A4
  • (Z)-CombretastatinA4
  • combretastatin A-4 (CA-4)
  • 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
  • Combrestatin A4
  • (Z)-2-Methoxy-5-[2-(3,4,5-triMethoxyphenyl)ethenyl]phenol, 3,4,5-TriMethoxy-3'-hydroxy-4'-Methoxy-(Z)-stilbene
  • CS-A4
  • CoMbretastatin A
  • CA-4, Combretastatin A-4
  • 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene
  • CA4
  • (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol
  • 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
  • (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol
  • Combretastatin A4 (CRC 87-09)
  • Combretastatin A4 &gt
  • Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
  • Recombinant Human Carbonic Anhydrase IV/CA4 Protein, His Tag
  • 3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
  • Combretastatin TXB-4
  • NSC 817373
  • NSC-817373
  • 117048-59-6
  • 17048-59-6
  • API
  • Anti-cancer & immunity
  • Inhibitors
  • Combretastatin