PD 173074
- Product Name
- PD 173074
- CAS No.
- 219580-11-7
- Chemical Name
- PD 173074
- Synonyms
- CS-458;PD176074;PD-0173074;PD173074, >=98%;PD173074/PD-173074;PD 173074, Free Base;Cholest-5-en-3-ol,(9α)-;PD-173074 FGFR1 FGFR3 inhibitor ab141117;FGF/VEGF Receptor Tyrosine Kinase Inhibitor;FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
- CBNumber
- CB9497090
- Molecular Formula
- C28H41N7O3
- Formula Weight
- 523.67
- MOL File
- 219580-11-7.mol
PD 173074 Property
- Melting point:
- 82-85°C
- Density
- 1.163
- storage temp.
- 2-8°C
- solubility
- DMSO: 21 mg/mL
- form
- solid
- pka
- 10.12±0.43(Predicted)
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- P2499
- Product name
- PD 173074
- Purity
- ≥96% (HPLC), powder
- Packaging
- 5mg
- Price
- $279
- Updated
- 2024/03/01
- Product number
- 341607
- Product name
- FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
- Packaging
- 5mg
- Price
- $475
- Updated
- 2024/03/01
- Product number
- P2474
- Product name
- PD 173074
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- P2474
- Product name
- PD 173074
- Purity
- >95.0%(HPLC)
- Packaging
- 50mg
- Price
- $416
- Updated
- 2024/03/01
- Product number
- 13032
- Product name
- PD 173074
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $39
- Updated
- 2024/03/01
PD 173074 Chemical Properties,Usage,Production
Description
PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1?(IC50?values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3
Chemical Properties
Yellow Solid
Uses
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.
Uses
A selective FGFR1 and
Uses
PD 173074 ar signal-related kinase phosphorylation.
Definition
ChEBI: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at pos tions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.
Biological Activity
Selective FGFR1 and FGFR3 inhibitor (IC 50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors.
Biochem/physiol Actions
PD 173074 is a fibroblast growth factor receptor 3 (FGFR3) inhibitor: IC50 = 5 nM inhibition of FGFR3 autophosphorylation. PD 173074 arrests the G0/G1 phase of FGFR3-expressing cells. It is 100-fold more selective for FGFR3 than for VEGF receptors, IGF-1 receptors, and MAPKs.
in vitro
pd173074 was found to block h-510 and h-69 sclc proliferation and clonogenic growth in a dose-dependent fashion and prevent fgf-2-induced chemoresistance as well. these effects correlate with the inhibition of both fgfr1 and fgfr2 transphosphorylation. in addition, pd173074 showed a high degree of selectivity for fgfr tyrosine kinase [2].
in vivo
in the h-510 xenograft mouse model, tumor growth was significanlty improved similar to that seen with single-agent cisplatin administration. accordingly, pd173074 treatment resulted in significanlty prolonged median survival when compared with that of control sham-treated animals. more dramatically, pd173074 also induced complete responses lasting >6 months in 50% of in mice h-69 xenografts [2].
storage
+4°C
References
1 Bansal?et al. (2003),?Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res.,?74?486 2) Kim?et al. (2012),?Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs; Biotechnol. Prog.,?28?1384 3) Zaragosi?et al. (2006),?Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells,?24?2412
PD 173074 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 173074 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
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- United Kingdom
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- United Kingdom
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- Country
- United Kingdom
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- Tel
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from PD 173074 manufacturers
- Product
- PD 173074 219580-11-7
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20