PD 173074

Product Name: PD 173074
CAS No.: 219580-11-7
Chemical Name: PD 173074
Synonyms: CS-458;PD176074;PD-0173074;PD173074, >=98%;PD173074/PD-173074;PD 173074, Free Base;Cholest-5-en-3-ol,(9α)-;PD-173074 FGFR1 FGFR3 inhibitor ab141117;FGF/VEGF Receptor Tyrosine Kinase Inhibitor;FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
CBNumber: CB9497090
Molecular Formula: C28H41N7O3
Formula Weight: 523.67
MOL File: 219580-11-7.mol

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PD 173074 Property

Melting point:: 82-85°C
Density: 1.163
storage temp.: 2-8°C
solubility: DMSO: 21 mg/mL
form: solid
pka: 10.12±0.43(Predicted)
color: yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P2499
Product name: PD 173074
Purity: ≥96% (HPLC), powder
Packaging: 5mg
Price: $279
Updated: 2024/03/01

Sigma-Aldrich

Product number: 341607
Product name: FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
Packaging: 5mg
Price: $475
Updated: 2024/03/01

TCI Chemical

Product number: P2474
Product name: PD 173074
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $139
Updated: 2024/03/01

TCI Chemical

Product number: P2474
Product name: PD 173074
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $416
Updated: 2024/03/01

Cayman Chemical

Product number: 13032
Product name: PD 173074
Purity: ≥98%
Packaging: 5mg
Price: $39
Updated: 2024/03/01

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PD 173074 Chemical Properties,Usage,Production

Description

PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1?(IC50?values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3

Chemical Properties

Yellow Solid

Uses

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

Uses

A selective FGFR1 and

Uses

PD 173074 ar signal-related kinase phosphorylation.

Definition

ChEBI: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at pos tions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.

Biological Activity

Selective FGFR1 and FGFR3 inhibitor (IC 50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors.

Biochem/physiol Actions

PD 173074 is a fibroblast growth factor receptor 3 (FGFR3) inhibitor: IC50 = 5 nM inhibition of FGFR3 autophosphorylation. PD 173074 arrests the G0/G1 phase of FGFR3-expressing cells. It is 100-fold more selective for FGFR3 than for VEGF receptors, IGF-1 receptors, and MAPKs.

in vitro

pd173074 was found to block h-510 and h-69 sclc proliferation and clonogenic growth in a dose-dependent fashion and prevent fgf-2-induced chemoresistance as well. these effects correlate with the inhibition of both fgfr1 and fgfr2 transphosphorylation. in addition, pd173074 showed a high degree of selectivity for fgfr tyrosine kinase [2].

in vivo

in the h-510 xenograft mouse model, tumor growth was significanlty improved similar to that seen with single-agent cisplatin administration. accordingly, pd173074 treatment resulted in significanlty prolonged median survival when compared with that of control sham-treated animals. more dramatically, pd173074 also induced complete responses lasting >6 months in 50% of in mice h-69 xenografts [2].

storage

+4°C

References

1 Bansal?et al. (2003),?Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res.,?74?486 2) Kim?et al. (2012),?Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs; Biotechnol. Prog.,?28?1384 3) Zaragosi?et al. (2006),?Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells,?24?2412

PD 173074 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 173074 Suppliers

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View Lastest Price from PD 173074 manufacturers

Career Henan Chemical Co

Product: PD 173074 219580-11-7
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

219580-11-7, PD 173074Related Search:

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CS-458

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

FGF/VEGF Receptor Tyrosine Kinase Inhibitor

PD 173074;PD-173074;FGF/VEGF RECEPTOR TYROSINE KINASE INHIBITOR

n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea

N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-

PD173074/PD-173074

1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-

Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-

PD176074

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074

PD 173074 N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

PD-0173074

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimid

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074

PD 173074, Free Base

PD173074, >=98%

1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea

Cholest-5-en-3-ol,(9α)-

PD-173074 FGFR1 FGFR3 inhibitor ab141117

Inhibitor,Fibroblast growth factor receptor,PD173074,Apoptosis,Vascular endothelial growth factor receptor,inhibit,PD 173074,FGFR,PD-173074,VEGFR

N-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

219580-11-7

C28H41N7O3

Antineoplastic

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