PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
- Product Name
- PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
- CAS No.
- 4664-08-8
- Chemical Name
- PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
- Synonyms
- FURO[3,4-C]PYRIDINE-1,3-DIONE;3,4-PYRIDINEDICARBOXYLIC ANHYDRIDE;CINCHOMERONIC ANHYDRIDE;PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE;1H,3H-furo[3,4-c]pyridine-1,3-dione;3,4-Pyridinecarboxylic acid anhydride;3,4-Pyridinecarboxylic anhydride, 97%;3,4-Pyridinedicarboxylic anhydride 97%;3,4-PYRIDINEDICARBOXYLIC ACID ANHYDRIDE;3,4-Pyridinedicarboxylic anhydride ,97%
- CBNumber
- CB9671924
- Molecular Formula
- C7H3NO3
- Formula Weight
- 149.1
- MOL File
- 4664-08-8.mol
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Property
- Melting point:
- 75-77 °C (lit.)
- Boiling point:
- 139-142 °C(Press: 12 Torr)
- Density
- 1.556±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -0.38±0.20(Predicted)
- form
- solid
- color
- White to off-white
- Water Solubility
- Decomposes in water.
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C7H3NO3/c9-6-4-1-2-8-3-5(4)7(10)11-6/h1-3H
- InChIKey
- KFKMGUPDWTWQFM-UHFFFAOYSA-N
- SMILES
- C1=NC=CC2C(=O)OC(=O)C1=2
- CAS DataBase Reference
- 4664-08-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 282715
- Product name
- 3,4-Pyridinedicarboxylic anhydride
- Purity
- 97%
- Packaging
- 1g
- Price
- $55.5
- Updated
- 2023/01/07
- Product number
- 282715
- Product name
- 3,4-Pyridinedicarboxylic anhydride
- Purity
- 97%
- Packaging
- 5g
- Price
- $178
- Updated
- 2023/01/07
- Product number
- P3035
- Product name
- Furo[3,4-c]pyridine-1,3-dione
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $45
- Updated
- 2025/07/31
- Product number
- P3035
- Product name
- Furo[3,4-c]pyridine-1,3-dione
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $135
- Updated
- 2025/07/31
- Product number
- P991905
- Product name
- 3,4-Pyridinedicarboxylic anhydride
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Chemical Properties,Usage,Production
Chemical Properties
White to light yellow solid
Uses
Pyridine-3,4-dicarboxylic anhydride is an important organic intermediate. It is used in agrochemical, pharmaceutical and dyestuff field.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 37, p. 828, 1994 DOI: 10.1021/jm00032a018
The Journal of Organic Chemistry, 14, p. 97, 1949 DOI: 10.1021/jo01153a015
Synthesis
490-11-9
4664-08-8
The general procedure for the synthesis of pyridine-3,4-dicarboxylic anhydride from 3,4-pyridinedicarboxylic acid is as follows: in a 1 L round-bottomed flask fitted with a drying tube, 3,4-pyridinedicarboxylic acid (160 g, 1 mol) and acetic anhydride (500 mL) were added. The reaction mixture was refluxed in an oil bath at 165°C for 2 hours. Upon completion of the reaction, decompression concentration was carried out to remove excess acetic anhydride. After cooling, a residual oily substance was obtained. Methyl tert-butyl ether (500 mL) was added to the residue and stirred overnight at room temperature. Subsequently, a dark brown solid precipitate precipitated and was separated by filtration. The filter cake was washed with 100 mL of methyl tert-butyl ether (MTBE) and dried under vacuum at 45°C to give 99 g of solid product in 76% yield.
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 22, p. 5891 - 5899
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 6, p. 828 - 837
[3] Patent: EP503537, 1992, A1
[4] Patent: CN104557704, 2017, B. Location in patent: Paragraph 0042; 0043; 0044
[5] Monatshefte fuer Chemie, 1890, vol. 11, p. 144
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Suppliers
- Tel
- --
- Fax
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- info@specs.net
- Country
- The Netherlands
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- 6833
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View Lastest Price from PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE manufacturers
- Product
- Pyridine-3,4-Dicarboxylic Anhydride 4664-08-8
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-31
- Product
- PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE 4664-08-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11