2,3-Difluorobenzyl alcohol
- Product Name
- 2,3-Difluorobenzyl alcohol
- CAS No.
- 75853-18-8
- Chemical Name
- 2,3-Difluorobenzyl alcohol
- Synonyms
- RARECHEM AL BD 0211;2,3-Difluorophenyl alcohol;2,3-DIFLUOROBENZYL ALCOHOL;2,3-difluoro-Benzenemethanol;(2,3-Difluorophenyl)methanol;2,3-Difluorobenzylalcohol98%;Benzenemethanol, 2,3-difluoro-;2,3-Difluorobenzyl Alcohol >2,3-Difluorobenzyl alcohol,94%;2,3-Difluorobenzyl alcohol 98%
- CBNumber
- CB9671979
- Molecular Formula
- C7H6F2O
- Formula Weight
- 144.12
- MOL File
- 75853-18-8.mol
2,3-Difluorobenzyl alcohol Property
- Boiling point:
- 101.45°C (rough estimate)
- Density
- 1.282 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.492(lit.)
- Flash point:
- 201 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 13.61±0.10(Predicted)
- Specific Gravity
- 1.282
- color
- Clear colorless to pale brown
- Water Solubility
- Slightly soluble in water.
- BRN
- 7089243
- CAS DataBase Reference
- 75853-18-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,3-Difluorobenzyl alcohol(75853-18-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 41-36/37/38
- Safety Statements
- 26-39-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29062990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290262
- Product name
- 2,3-Difluorobenzyl alcohol
- Purity
- 94%
- Packaging
- 5g
- Price
- $55.5
- Updated
- 2022/05/15
- Product number
- D4619
- Product name
- 2,3-Difluorobenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- D4619
- Product name
- 2,3-Difluorobenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $221
- Updated
- 2025/07/31
- Product number
- D451423
- Product name
- 2,3-Difluorobenzyl alcohol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2601-3-19
- Product name
- 2,3-Difluorobenzyl alcohol
- Purity
- 98%
- Packaging
- 5G
- Price
- $36
- Updated
- 2021/12/16
2,3-Difluorobenzyl alcohol Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to pale brown liquid
Uses
It is used to produce 1-bromomethyl-2,3-difluoro-benzene with reagent PBr3 and solvent toluene at the temperature of 100°C for 1 hour. 2,3-Difluorobenzyl alcohol may be used in chemical synthesis studies.
Definition
ChEBI: 2,3-difluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by fluoro groups at positions 2 and 3 respectively. It is an organofluorine compound and a member of benzyl alcohols.
Synthesis
2646-91-5
75853-18-8
Step 1 (MW-Si): sodium borohydride (5.3 g, 140.84 mmol) was slowly added to a methanolic solution (200 mL) of 2,3-difluorobenzaldehyde (20 g, 140.84 mmol) in three batches (each batch was separated by more than 25 min) at 0 °C. The temperature rose to 50°C due to exothermic during the reaction. The reaction mixture was continued to be stirred for 1 hour and then the solvent was removed by distillation under reduced pressure. Subsequently, the residue was extracted by adding ethyl acetate and saturated ammonium chloride solution to the residue. After separation of the organic layer, the aqueous layer was extracted again with ethyl acetate. All organic layers were combined, washed sequentially with water and saturated brine, and then dried with anhydrous sodium sulfate. Finally, 20 g of MW-Si (2,3-difluorobenzyl alcohol) was obtained by vacuum concentration as a colorless liquid, which could be used in subsequent steps without further purification.
References
[1] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 169
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1345 - 1360
2,3-Difluorobenzyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Difluorobenzyl alcohol manufacturers
- Product
- 2,3-Difluorobenzyl alcohol 75853-18-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17
- Product
- 2,3-Difluorobenzyl alcohol 75853-18-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25