2,3-Difluorobenzyl alcohol

Product Name: 2,3-Difluorobenzyl alcohol
CAS No.: 75853-18-8
Chemical Name: 2,3-Difluorobenzyl alcohol
Synonyms: RARECHEM AL BD 0211;2,3-Difluorophenyl alcohol;2,3-DIFLUOROBENZYL ALCOHOL;2,3-difluoro-Benzenemethanol;(2,3-Difluorophenyl)methanol;2,3-Difluorobenzylalcohol98%;Benzenemethanol, 2,3-difluoro-;2,3-Difluorobenzyl Alcohol >2,3-Difluorobenzyl alcohol,94%;2,3-Difluorobenzyl alcohol 98%
CBNumber: CB9671979
Molecular Formula: C7H6F2O
Formula Weight: 144.12
MOL File: 75853-18-8.mol

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2,3-Difluorobenzyl alcohol Property

Boiling point:: 101.45°C (rough estimate)
Density: 1.282 g/mL at 25 °C (lit.)
refractive index: n20/D 1.492(lit.)
Flash point:: 201 °F
storage temp.: Sealed in dry,Room Temperature
form: Liquid
pka: 13.61±0.10(Predicted)
Specific Gravity: 1.282
color: Clear colorless to pale brown
Water Solubility: Slightly soluble in water.
BRN: 7089243
CAS DataBase Reference: 75853-18-8(CAS DataBase Reference)
NIST Chemistry Reference: 2,3-Difluorobenzyl alcohol(75853-18-8)

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Safety

Hazard Codes: Xi
Risk Statements: 41-36/37/38
Safety Statements: 26-39-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29062990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290262
Product name: 2,3-Difluorobenzyl alcohol
Purity: 94%
Packaging: 5g
Price: $55.5
Updated: 2022/05/15

TCI Chemical

Product number: D4619
Product name: 2,3-Difluorobenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 5g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: D4619
Product name: 2,3-Difluorobenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 25g
Price: $221
Updated: 2025/07/31

TRC

Product number: D451423
Product name: 2,3-Difluorobenzyl alcohol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2601-3-19
Product name: 2,3-Difluorobenzyl alcohol
Purity: 98%
Packaging: 5G
Price: $36
Updated: 2021/12/16

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2,3-Difluorobenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale brown liquid

Uses

It is used to produce 1-bromomethyl-2,3-difluoro-benzene with reagent PBr3 and solvent toluene at the temperature of 100°C for 1 hour. 2,3-Difluorobenzyl alcohol may be used in chemical synthesis studies.

Definition

ChEBI: 2,3-difluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by fluoro groups at positions 2 and 3 respectively. It is an organofluorine compound and a member of benzyl alcohols.

Synthesis

2646-91-5

75853-18-8

Step 1 (MW-Si): sodium borohydride (5.3 g, 140.84 mmol) was slowly added to a methanolic solution (200 mL) of 2,3-difluorobenzaldehyde (20 g, 140.84 mmol) in three batches (each batch was separated by more than 25 min) at 0 °C. The temperature rose to 50°C due to exothermic during the reaction. The reaction mixture was continued to be stirred for 1 hour and then the solvent was removed by distillation under reduced pressure. Subsequently, the residue was extracted by adding ethyl acetate and saturated ammonium chloride solution to the residue. After separation of the organic layer, the aqueous layer was extracted again with ethyl acetate. All organic layers were combined, washed sequentially with water and saturated brine, and then dried with anhydrous sodium sulfate. Finally, 20 g of MW-Si (2,3-difluorobenzyl alcohol) was obtained by vacuum concentration as a colorless liquid, which could be used in subsequent steps without further purification.

References

[1] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 169
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1345 - 1360

2,3-Difluorobenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Difluorobenzyl alcohol Suppliers

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View Lastest Price from 2,3-Difluorobenzyl alcohol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3-Difluorobenzyl alcohol 75853-18-8
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Career Henan Chemical Co

Product: 2,3-Difluorobenzyl alcohol 75853-18-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

75853-18-8, 2,3-Difluorobenzyl alcoholRelated Search:

Florfenicol Ethyl acetate 1,2-Difluorobenzene 3-Fluorobenzyl alcohol Benzyl alcohol 1,3-Difluorobenzene 4-Fluorobenzyl alcohol Transfluthrin ETHYL PENTAFLUOROBENZOATE 2,3-Difluorobenzoic acid Tetrafluorophthalic acid Tetrafluoroterephthalic acid 2,3,4,5-Tetrafluorobenzoic acid METHYL PENTAFLUOROBENZOATE 2,4-Dinitrofluorobenzene O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Pentafluorobenzoic acid 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID

2,3-DIFLUOROBENZYL ALCOHOL

2,3-Difluorobenzyl alcohol 98%

2,3-Difluorobenzylalcohol98%

2,3-Difluorobenzyl alcohol,94%

2,3-Difluorophenyl alcohol

2,3-difluorobenzyl alcohol / 2,3-difluorobenzyl alcohol

(2,3-Difluorophenyl)methanol

RARECHEM AL BD 0211

2,3-difluoro-Benzenemethanol

2,3-Difluorobenzyl Alcohol &gt

Benzenemethanol, 2,3-difluoro-

75853-18-8

ALCOHOL

C7 to C8

Building Blocks

Alcohols

Oxygen Compounds

Organic Building Blocks

Aromatic compound

Miscellaneous

Alcohols

C7 to C8

Oxygen Compounds

Fluorine series

Benzhydrols, Benzyl & Special Alcohols