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tert-Butyl carbazate

Product Name
tert-Butyl carbazate
CAS No.
870-46-2
Chemical Name
tert-Butyl carbazate
Synonyms
tert-butyl hydrazinecarboxylate;carbazate;BOC-NHNH2;BOC-HYDRAZINE;T-BUTYLCARBAZATE;tert-Butyl N-aminocarbamate;HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER;BOC-HYDRAZIDE;TERT-BUTOXYCARBONYL HYDRAZIDE;T-BOC-HYDRAZIDE
CBNumber
CB9686391
Molecular Formula
C5H12N2O2
Formula Weight
132.16
MOL File
870-46-2.mol
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tert-Butyl carbazate Property

Melting point:
39-42 °C (lit.)
Boiling point:
63-65 °C/0.1 mmHg (lit.)
Density 
1.02
refractive index 
1.4496 (estimate)
Flash point:
197 °F
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in ethanol and methanol.
pka
10.74±0.20(Predicted)
form 
Crystalline Lumps
color 
White to slightly yellow
Sensitive 
Moisture Sensitive
BRN 
1756967
InChIKey
DKACXUFSLUYRFU-UHFFFAOYSA-N
CAS DataBase Reference
870-46-2(CAS DataBase Reference)
EPA Substance Registry System
Hydrazinecarboxylic acid, 1,1-dimethylethyl ester (870-46-2)
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Safety

Hazard Codes 
T-F,T,F
Risk Statements 
48-36/37/38-24/25-11
Safety Statements 
45-36/37/39-16-24/25
RIDADR 
1325
WGK Germany 
3
F 
21
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29280090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B91005
Product name
tert-Butyl carbazate
Purity
98%
Packaging
5g
Price
$38.5
Updated
2024/03/01
Sigma-Aldrich
Product number
B91005
Product name
tert-Butyl carbazate
Purity
98%
Packaging
25g
Price
$79.4
Updated
2024/03/01
Alfa Aesar
Product number
A12383
Product name
tert-Butyl carbazate, 98+%
Packaging
25g
Price
$74.2
Updated
2024/03/01
Alfa Aesar
Product number
A12383
Product name
tert-Butyl carbazate, 98+%
Packaging
100g
Price
$126.65
Updated
2024/03/01
Sigma-Aldrich
Product number
B91005
Product name
tert-Butyl carbazate
Purity
98%
Packaging
100g
Price
$148
Updated
2024/03/01
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tert-Butyl carbazate Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow lumps

Uses

Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection.

Uses

tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018
Chemical and Pharmaceutical Bulletin, 18, p. 217, 1970 DOI: 10.1248/cpb.18.217

Purification Methods

Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.]

tert-Butyl carbazate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Di-tert-butyl dicarbonate Hydrazine hydrate Isopropyl alcohol

Preparation Products

PYRIDIN-2-YLMETHYL-HYDRAZINE PYRIDIN-3-YLMETHYL-HYDRAZINE (2-METHOXY-1-METHYL-ETHYL)-HYDRAZINE PYRIDIN-4-YLMETHYL-HYDRAZINE CYCLOBUTYLHYDRAZINE 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
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tert-Butyl carbazate Suppliers

Australia 1 Belgium 4 Canada 2 China 451 Europe 1 France 2 Germany 14 India 72 Japan 8 Spain 1 Sweden 2 Switzerland 3 The Netherlands 1 United Kingdom 14 United States 52 Global 628
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View Lastest Price from tert-Butyl carbazate manufacturers

Hebei Longbang Technology Co., Ltd
Product
tert-Butyl carbazate 870-46-2
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-06-03
hebei hongtan Biotechnology Co., Ltd
Product
Tert-Butyl carbazate 870-46-2
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-13
Hebei Weibang Biotechnology Co., Ltd
Product
tert-Butyl carbazate 870-46-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01

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