ChemicalBook > CAS DataBase List > Vardenafil dihydrochloride

Vardenafil dihydrochloride

Product Name: Vardenafil dihydrochloride
CAS No.: 224789-15-5
Chemical Name: Vardenafil dihydrochloride
Synonyms: Levitra;VARDANAFIL;Vardenafil 2HCl;Vardenafil DiHCl;VARDENAFIL CITRATE;Vardenafil Sexual Powder;Vardenafil dihydrochloride;Vardenafil dihydrochloride solution;VARDENAFILDIHYDROCHLORIDE(SUBJECTTOPATENTFREE);Vardenafil dihydrochloride 100 μg/mL in Acetonitrile
CBNumber: CB9712210
Molecular Formula: C23H33ClN6O4S
Formula Weight: 525.07
MOL File: 224789-15-5.mol

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Vardenafil dihydrochloride Property

Melting point:: 214-216°C
storage temp.: Refrigerator
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
color: White to Off-White
InChIKey: NOIHTGOGFDFCBN-UHFFFAOYSA-N
SMILES: C1N(S(=O)(=O)C2C=C(C3NC(=O)C4=C(C)N=C(CCC)N4N=3)C(OCC)=CC=2)CCN(CC)C1.Cl.Cl
CAS DataBase Reference: 224789-15-5(CAS DataBase Reference)

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: V098001
Product name: VardenafilDihydrochlorideSalt
Packaging: 50mg
Price: $400
Updated: 2021/12/16

Axon Medchem

Product number: Axon3396
Product name: Vardenafildihydrochloride-BAY38–9456
Purity: 99%
Packaging: 10mg
Price: $66
Updated: 2021/12/16

Axon Medchem

Product number: Axon3396
Product name: Vardenafildihydrochloride-BAY38–9456
Purity: 99%
Packaging: 50mg
Price: $132
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019443
Product name: VARDENAFIL DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.59
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 67460
Product name: VardenafilDiHClSalt
Packaging: 10mg
Price: $610
Updated: 2021/12/16

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Vardenafil dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Cyrstalline Solid

Uses

erectile dysfunction, PD5 inhibitor

Uses

Vardenafil Dihydrochloride Salt is a selective phosphodiesterase type 5 (PDE5) inhibitor.

Uses

A selective phsphodiesterase type 5 (PDE5) inhibitor.

in vivo

Vardenafil dihydrochloride (0.03 mg/kg; i.v.) exhibits facilitator effects in rats with cavernous nerve injury^[4].
Vardenafil dihydrochloride (0.17 mg/kg; i.v.; once daily; 7 d) protects liver against Con A–induced hepatitis, and decreases the expression of NF-??B and iNOS in hepatic tissue^[5].
Vardenafil dihydrochloride (10 mg/kg; p.o.; once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts^[6].

Animal Model:	Male rat (9-week-old) underwent surgery for laparotomy or bilateral cavernous nerve (CN) crush injury^[4]
Dosage:	0.03 mg/kg
Administration:	Intravenous injection
Result:	Restored normal erectile responses with a combind administration of BAY 60-4552 (0.03, 0.3 mg/kg).

Animal Model:	Liver injury induced by Con A in male Swiss albino mice (20 ± 2 g)^[5]
Dosage:	0.17 mg/kg
Administration:	Intravenous injection; once daily, for 7 days; as a pretreatment
Result:	Reduced the levels of serum transaminases and alleviated Con A-induced hepatitis.

Animal Model:	Male 7-week-old Zucker diabetic fatty (ZDF) rats (preserved ejection fraction, HFpEF)^[6]
Dosage:	10 mg/kg
Administration:	Oral gavage; once daily, for 25 weeks
Result:	Improved myofilament function in diabetic rat hearts.

IC 50

PDE5: 0.7 nM (IC₅₀); PDE1: 180 nM (IC₅₀); PDE6: 11 nM (IC₅₀)

Vardenafil dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vardenafil dihydrochloride manufacturers

Forest chemical technology

Product: Vardenafil dihydrochloride 224789-15-5
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 1 ton/year
Release date: 2025-01-09

Hebei Ganmiao New material Technology Co., LTD

Product: Vardenafil dihydrochloride 224789-15-5
Price: US $10.00-8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-06

Wuhan Xinhao Biotechnology Co., Ltd

Product: Vardenafil dihydrochloride 224789-15-5
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-08

224789-15-5, Vardenafil dihydrochlorideRelated Search:

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VARDENAFIL CITRATE

VARDANAFIL

VARDENAFILDIHYDROCHLORIDE(SUBJECTTOPATENTFREE)

1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine dihydrochloride

Levitra

Vardenafil dihydrochloride

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride

2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

Vardenafil dihydrochloride solution

Vardenafil DiHCl

Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, dihydrochloride

Vardenafil Sexual Powder

Vardenafil 2HCl

Vardenafil dihydrochloride 100 μg/mL in Acetonitrile

Vardenafil Dihydrochloride 1.0 mg/ml in Methanol (as free base)

224789-15-5

C23H32N6O4S2HClC23H34Cl2N6O4S

C23H32N6O4S2HCl

Active Pharmaceutical Ingredients

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

LEVITRA

224789-15-5