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Pheniramine maleate

Product Name
Pheniramine maleate
CAS No.
132-20-7
Chemical Name
Pheniramine maleate
Synonyms
Pheneramine Maleate;PHENIRAMINE MALEATE SALT;pm241;Fervex;daneral;ho11513;inhiston;Trimetose;205-051-4;Antolozine
CBNumber
CB9727768
Molecular Formula
C20H24N2O4
Formula Weight
356.42
MOL File
132-20-7.mol
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Pheniramine maleate Property

Melting point:
104-108°C
Boiling point:
489.25°C (rough estimate)
Density 
1.2233 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
2-8°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form 
Solid
color 
White
Water Solubility 
>=1 g/100 mL at 24 ºC
λmax
262nm(lit.)
Merck 
14,7235
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
132-20-7(CAS DataBase Reference)
EPA Substance Registry System
Pheniramine maleate (132-20-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
UT0175000
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2646
Product name
Pheniramine Maleate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
300MG
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
P6902
Product name
Pheniramine maleate salt
Packaging
5g
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
1522301
Product name
Pheniramine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
P2271
Product name
Pheniramine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$139
Updated
2024/03/01
Sigma-Aldrich
Product number
P0850000
Product name
Pheniramine maleate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
p0850000
Price
$153
Updated
2024/03/01
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Pheniramine maleate Chemical Properties,Usage,Production

Chemical Properties

white powder

Originator

Trimeton Maleate, Schering ,US,1948

Uses

Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.

Definition

ChEBI: Pheniramine maleate is an organic molecular entity.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the Pheniramine, BP 139°-142°C/1-2 mm. The Pheniramine maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

General Description

White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.

General Description

Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.

Biochem/physiol Actions

Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.

Side effects

Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur. 

Pheniramine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pheniramine maleate Suppliers

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View Lastest Price from Pheniramine maleate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pheniramine maleate 132-20-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
100KG
Release date
2021-06-18
Baoji Guokang Bio-Technology Co., Ltd.
Product
Pheniramine maleate 132-20-7
Price
US $2150.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-20mt
Release date
2021-06-07
Hebei Weibang Biotechnology Co., Ltd
Product
Pheniramine maleate 132-20-7
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-01-21

132-20-7, Pheniramine maleateRelated Search:

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  • H1 histamine receptor antagonist.
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