3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
- Product Name
- 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
- CAS No.
- 850567-56-5
- Chemical Name
- 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
- Synonyms
- 2-Chloro-5-(4,4,5,5-tetram;3-Amino-4-chlorobenzeneboronic acid;3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER;(3-AMINO-4-CHLORO)BENZENEBORONIC ACID, PINACOL ESTER;3-Amino-4-chlorobenzeneboronic acid, pinacol ester 95%;2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2-chloro-5-(tetraMethyl-1,3,2-dioxaborolan-2- yl)aniline;6-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline;2-Chloro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline;2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anil...
- CBNumber
- CB9729409
- Molecular Formula
- C12H17BClNO2
- Formula Weight
- 253.53
- MOL File
- 850567-56-5.mol
3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER Property
- Melting point:
- 142-144
- Boiling point:
- 361.5±32.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2?+-.0.10(Predicted)
- form
- solid
- color
- Light Brown
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A617578
- Product name
- 3-Amino-4-chlorophenylboronicacid,pinacolester
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- P000668976
- Product name
- 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
- Purity
- 97%
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- P000668976
- Product name
- 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- FA160699
- Product name
- 3-Amino-4-chlorobenzeneboronic acid, pinacol ester
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 8H60-5-Y1
- Product name
- 3-Amino-4-chlorobenzeneboronic acid, pinacol ester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production
Synthesis
913836-26-7
850567-56-5
General procedure for the synthesis of 3-amino-4-chlorophenylboronic acid pinacol ester from 2-(4-chloro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane: Compound 1 (55.0 g, 190 mmol) was placed in a three-necked flask, and ethanol (500 mL), water (100 mL), and ammonium chloride (20.4 g, 390 mmol) were sequentially added. 390 mmol). Iron powder (49 g, 880 mmol) was added slowly with stirring at room temperature. The reaction mixture was heated to 105 °C and refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and filtered through diatomaceous earth to remove excess iron powder. Ethanol was removed by distillation under reduced pressure and water (100 mL) and saturated aqueous sodium bicarbonate solution (150 mL) were added. Extracted with ethyl acetate (200 mL x 3), the organic phases were combined, washed sequentially with saturated aqueous sodium bicarbonate (150 mL) and saturated brine (150 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was rotary evaporated to dryness to give compound 2 (45.5 g, 179 mmol, 94% yield) in yellow liquid form.
References
[1] Patent: CN107383076, 2017, A. Location in patent: Paragraph 0005; 0008-0010
[2] Journal of Organic Chemistry, 2014, vol. 79, # 5, p. 1979 - 1988
3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER manufacturers
- Product
- 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER 850567-56-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03