Methyl 6-methylnicotinate

Uses

Product Name: Methyl 6-methylnicotinate
CAS No.: 5470-70-2
Chemical Name: Methyl 6-methylnicotinate
Synonyms: METHYL 6-METHYLPYRIDINE-3-CARBOXYLATE;M6MN;6-Methyl Methyl Smoke;Etoricoxib Impurity E;LABOTEST-BB LT00847843;Methyl-6-methylnictinate;METHYL 6-METHYLNICOTINATE;5-CARBOMETHOXY-2-PICOLINE;Methyle6-methylnicotinate;Etoricoxib Intermediate 6
CBNumber: CB9730818
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 5470-70-2.mol

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Methyl 6-methylnicotinate Property

Melting point:: 34-37 °C (lit.)
Boiling point:: 160 °C/106 mmHg (lit.)
Density: 1.2023 (rough estimate)
refractive index: 1.5810 (estimate)
Flash point:: 218 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 3.92±0.10(Predicted)
form: Liquid
color: Clear colorless to slightly yellow
BRN: 122940
InChI: InChI=1S/C8H9NO2/c1-6-3-4-7(5-9-6)8(10)11-2/h3-5H,1-2H3
InChIKey: VYPPZXZHYDSBSJ-UHFFFAOYSA-N
SMILES: C1=NC(C)=CC=C1C(OC)=O
CAS DataBase Reference: 5470-70-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 284777
Product name: Methyl 6-methylpyridine-3-carboxylate
Purity: 97%
Packaging: 10g
Price: $148.4
Updated: 2025/07/31

TCI Chemical

Product number: M1893
Product name: Methyl 6-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: M1893
Product name: Methyl 6-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $113
Updated: 2025/07/31

Usbiological

Product number: M3515-01
Product name: Methyl 6-Methylnicotinate
Packaging: 5g
Price: $418
Updated: 2021/12/16

Usbiological

Product number: 281663
Product name: Methyl 6-methylnicotinate
Packaging: 5g
Price: $292
Updated: 2021/12/16

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Methyl 6-methylnicotinate Chemical Properties,Usage,Production

Uses

It is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.

Chemical Properties

Brown Solid

Uses

Methyl 6-methylpyridine-3-carboxylate may be used in chemical synthesis studies.

Uses

Methyl 6-methylnicotinate is used in the treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 97, p. 4409, 1975 DOI: 10.1021/ja00848a053

Synthesis

67-56-1

3222-47-7

5470-70-2

To a stirred solution of 6-methylpyridine-3-carboxylic acid (40 g; 290 mmol; 1 equiv.) in methanol (0.75 L) was slowly added concentrated sulfuric acid (40 mL), and the reaction mixture was heated to reflux and held for 17 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure. Subsequently, the pH of the residue was adjusted to 7 with ice-cold saturated aqueous NaHCO3 and solid NaHCO3. The aqueous layer was extracted with ethyl acetate (3 x 500 mL), the organic layers were combined, washed with saturated brine, dried with anhydrous sodium sulfate, and the solvent was removed by filtration and under reduced pressure to give methyl 6-methylnicotinate (33 g, 75% yield) as an off-white solid. The product was confirmed by 1H NMR (CDCl3): δ 9.06 (s, 1H), 8.13 (dd, 1H, J = 2,8Hz), 7.20 (d, 1H, J = 8Hz), 3.89 (s, 3H), 2.58 (s, 3H).LCMS analysis showed: m/z = 152.4 [M + H]+, retention time RT = 2.36 min (using program P1, column W).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0152; 0153; 0154
[2] Journal of Organic Chemistry, 1981, vol. 46, # 15, p. 3040 - 3048
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 23, p. 5005 - 5022
[4] Patent: WO2010/48010, 2010, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2013/128421, 2013, A1. Location in patent: Page/Page column 80

Methyl 6-methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

5-Amino-2-methylpyridine

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Methyl 6-methylnicotinate Suppliers

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View Lastest Price from Methyl 6-methylnicotinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl 6-methylnicotinate 5470-70-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 5000kg/month
Release date: 2023-01-05

Asia Chem I and E (Jiangsu) Co Ltd

Product: Methyl 6-methylpyridine-3-carboxylate 5470-70-2
Price: US $65.58/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 3tons/month
Release date: 2021-11-09

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Methyl 6-methylnicotinate 5470-70-2
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-06-07

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LABOTEST-BB LT00847843

METHYL 6-METHYLPYRIDINE-3-CARBOXYLATE

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Methyl 6-methylpyridine-3-carboxylate 97%

6-methyl-3-pyridinecarboxylic acid methyl ester

Methyle6-methylnicotinate

6-Methyl Methyl Smoke

Etoricoxib Intermediate 6

Methyl 6-Methylnicotinate, 95+%

Etoricoxib Impurity E

Methyl6-Methylnicotinate&gt

M6MN

Methyl 6-methylnicotinate ISO 9001：2015 REACH

Methyl-6-Methylnicotinate (6-MNCT)

Etoricoxib Related Compound E

METHYL6 METHYL NICOTINATE (M6MN)

METHYLE 6 METHYLE NICOTINATE

Chemicalbook6-METHYLNICOTINICACIDMETHYLESTER

6-METHYLNICOTINATINIC ACID METHYL ESTER

Methyl-6-methyInicotinate

6- Methyl MethylNicotinate

Methyl 6-methyl-3-pyridinecarboxylate

Methyl 6-methylpyridin-3-carboxylate

5470-70-2

5770-70-2

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