Chlortetracycline hydrochloride

Product Name: Chlortetracycline hydrochloride
CAS No.: 64-72-2
Chemical Name: Chlortetracycline hydrochloride
Synonyms: CHLORTETRACYCLINE HCL;CTC;AUREOMYCIN;CHLOROTETRACYCLINE HYDROCHLORIDE;CHLOROTETRACYCLINE HCL;AUREOMYCIN HYDROCHLORIDE;u-6780;nsc-13252;Auxeomycin;Isphamycin
CBNumber: CB9737862
Molecular Formula: C22H24Cl2N2O8
Formula Weight: 515.34
MOL File: 64-72-2.mol

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Chlortetracycline hydrochloride Property

Melting point:: 210-215 °C (dec.)(lit.)
alpha: D23 -240°
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: 1 M NaOH: soluble50mg/mL
form: Powder
color: faint yellow to yellow
pka: 3.3(at 25℃)
Water Solubility: Soluble in water
Sensitive: Light Sensitive
Merck: 13,2211
BRN: 3858364
CAS DataBase Reference: 64-72-2(CAS DataBase Reference)
EPA Substance Registry System: Chlortetracycline hydrochloride (64-72-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: QI7800000
HazardClass: 3
HS Code: 29413020
Toxicity: LD50 orally in rats: 10300 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 26430
Product name: Chlortetracycline hydrochloride
Purity: suitable for fluorescence, BioReagent, from
Packaging: 5g
Price: $70.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46133
Product name: Chlortetracycline hydrochloride
Purity: VETRANAL?, analytical standard
Packaging: 250mg
Price: $74.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1129007
Product name: Chlortetracycline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $447
Updated: 2024/03/01

Alfa Aesar

Product number: J60095
Product name: Chlortetracycline hydrochloride
Packaging: 25g
Price: $128
Updated: 2024/03/01

Alfa Aesar

Product number: J60095
Product name: Chlortetracycline hydrochloride
Packaging: 100g
Price: $378
Updated: 2024/03/01

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Chlortetracycline hydrochloride Chemical Properties,Usage,Production

Description

Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.

Chemical Properties

Yellow Solid

Uses

antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis

Uses

Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.

Uses

An antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline

Uses

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

brand name

Aureomycin (Lederle).

General Description

Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.

Purification Methods

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]

Chlortetracycline hydrochloride Preparation Products And Raw materials

Raw materials

Hydrochloric acid Starch XANTHOPTERIN

Preparation Products

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View Lastest Price from Chlortetracycline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Chlortetracycline hydrochloride 64-72-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons/month
Release date: 2021-07-23

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Chlortetracycline hydrochloride 64-72-2
Price: US $0.00/kg
Min. Order: 25kg
Purity: ≥97.0%
Supply Ability: 1tons
Release date: 2024-04-28

Apeloa production Co.,Limited

Product: Chlortetracyclin hydrochloride 64-72-2
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1000
Release date: 2024-06-11

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