ChemicalBook > CAS DataBase List > Z-FA-FMK

Z-FA-FMK

Product Name
Z-FA-FMK
CAS No.
105637-38-5
Chemical Name
Z-FA-FMK
Synonyms
Z-FA-FMK;Z-PHE-ALA-FMK;Z-PHE-ALA-CH2F;(S,S)-Z-FA-FMK;CATHEPSIN B, INHIBITOR;Z-FA-FLUOROMETHYLKETONE;CATHEPSIN B, INHIBITOR I;Z-PHE-ALA-FLUOROMETHYLKETONE;CASPASE INHIBITOR, NEGATIVE CONTROL;Z-FA-FMK, Cysteine protease inhibitor
CBNumber
CB9749490
Molecular Formula
C21H23FN2O4
Formula Weight
386.42
MOL File
105637-38-5.mol
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Z-FA-FMK Property

Melting point:
125 - 127°C
Boiling point:
630.5±55.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO or DMF: 20 mM
form 
powder
pka
11.07±0.46(Predicted)
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1480
Product name
Z-Phe-Ala fluoromethyl ketone
Purity
≥90% (TLC), powder
Packaging
3mg
Price
$297
Updated
2025/07/31
ApexBio Technology
Product number
A8170
Product name
Z-FA-FMK
Packaging
10mM(in 1mL DMSO)
Price
$250
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000079
Product name
Z-FA-FMK
Purity
95.00%
Packaging
1MG
Price
$257.25
Updated
2021/12/16
ApexBio Technology
Product number
A8170
Product name
Z-FA-FMK
Packaging
1unit
Price
$28
Updated
2021/12/16
ApexBio Technology
Product number
A8170
Product name
Z-FA-FMK
Packaging
1mg
Price
$60
Updated
2021/12/16
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Z-FA-FMK Chemical Properties,Usage,Production

Uses

Cell permeable negative control for FMK-labelled caspase inhibitors. Also an irreversible inhibitor of cathepsins B, L, and S

Uses

Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.

Biological Activity

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor K-light-chain-enhancer of activated B cells (NF-KB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

Z-FA-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-FA-FMK Suppliers

China 66 Germany 1 Switzerland 2 United Kingdom 1 United States 13 Global 83
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105637-38-5, Z-FA-FMKRelated Search:

Z-DEVD-FMK Z-Vad-fmk, non-methylated Z-VAD-FMK BIOTIN-FA-FMK,BIOTIN-PHE-ALA-FLUOROMETHYLKETONE Caspase FMK Negative Control, Z-FA-FMK Z-FA-FMK Z-PHE-PHE-FLUOROMETHYLKETONE Z-PHE-DL-ALA-FLUOROMETHYLKETONE

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