ChemicalBook > CAS DataBase List > 4-Amino-5-aminomethyl-2-methylpyrimidine

4-Amino-5-aminomethyl-2-methylpyrimidine

Product Name
4-Amino-5-aminomethyl-2-methylpyrimidine
CAS No.
95-02-3
Chemical Name
4-Amino-5-aminomethyl-2-methylpyrimidine
Synonyms
Grewe DiaMine;4-amino-2-methylpyrimidine-5-methylamine;2-methyl-4-amino-5-aminomethylpyrimidine;Thiamine Impurity 16;Thiamine Impurity 48;Vitamin B1 Impurity 9;Diazinon Impurity 6 (Diazoxon);Thiamine /Vitamin B1 Impurity 19;2-Methyl-4-aminopyrimidine-5-methanamine;5-Aminomethyl-2-methyl-4-pyrimidineamine
CBNumber
CB9757404
Molecular Formula
C6H10N4
Formula Weight
138.17
MOL File
95-02-3.mol
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4-Amino-5-aminomethyl-2-methylpyrimidine Property

Melting point:
270-272°C
Boiling point:
121-125 °C
Density 
1.207
vapor pressure 
0.012-0.019Pa at 20-25℃
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form 
Solid
pka
7.70±0.29(Predicted)
color 
Off-White to Beige
PH
10.65 at 20℃ and 10g/L
InChI
InChI=1S/C6H10N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,2,7H2,1H3,(H2,8,9,10)
InChIKey
OZOHTVFCSKFMLL-UHFFFAOYSA-N
SMILES
C1(C)=NC=C(CN)C(N)=N1
LogP
-2.27 at 20℃ and pH7
Surface tension
72.77mN/m at 1g/L and 20℃
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2633
Product name
4-Amino-5-aminomethyl-2-methylpyrimidine
Packaging
200MG
Price
$211
Updated
2024/03/01
TRC
Product number
A581865
Product name
4-Amino-5-aminomethyl-2-methylpyrimidine
Packaging
1g
Price
$440
Updated
2021/12/16
Usbiological
Product number
A1374-66
Product name
4-Amino-5-aminomethyl-2-methylpyrimidine, Dihydrochloride
Packaging
500mg
Price
$460
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17606
Product name
4-Amino-5-aminomethyl-2-methylpyrimidine
Packaging
2g
Price
$520
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
6342
Product name
4-Amino-5-aminomethyl-2-methylpyrimidine
Packaging
1g
Price
$790
Updated
2021/12/16
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4-Amino-5-aminomethyl-2-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Substrate for TenA enzyme in the thiamin salvage pathway

Definition

ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively.

Synthesis

In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].

References

[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.

4-Amino-5-aminomethyl-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-5-aminomethyl-2-methylpyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Amino-5-aminomethyl-2-methylpyrimidine 95-02-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000KG
Release date
2024-08-14
Dideu Industries Group Limited
Product
4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE 95-02-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-13

95-02-3, 4-Amino-5-aminomethyl-2-methylpyrimidine Related Search:

Thiamine disulfide Thiamine chloride Cocarboxylase Nimustine Prosultiamine THIAMINE MONOPHOSPHATE CHLORIDE Amprolium Hydrochloride Thiamine nitrate 4-Amino-5-aminomethyl-2-methylpyrimidine Cocarboxylase tetrahydrate Amprolium 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium dodecyl sulfate 5-PYRIMIDINEMETHANAMINE 2-Methylpyrimidine HYDROXYETHYLTHIAMINE HYDROCHLORIDE 5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE THIAMINE DISULFIDE NITRATE THIOCHROME

  • 4-AMINO-2-METHYL-5-PYRIMIDINEMETHANAMINE, DIHYDROCHLORIDE
  • 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE
  • 4-amino-2-methylpyrimidine-5-methylamine
  • 5-Pyrimidinemethanamine, 4-amino-2-methyl- (9CI)
  • 5-(Aminomethyl)-4-amino-2-methylpyrimidine
  • 5-PyriMidineMethanaMine,4-aMino-2-Methyl-
  • 4-Amino-5-aminomethyl-2-methylpyrimidine hydrochloride
  • 2-methyl-4-amino-5-aminomethylpyrimidine 2HCl
  • 2-methyl-4-amino-5-aminomethylpyrimidine
  • 4-Amino-2-methyl-5-pyrimidinemethanamine,dihydrochlorine
  • 2-Methyl-4-aminopyrimidine-5-methanamine
  • 2-Methyl-5-(aminomethyl)-4-pyrimidinamine
  • 5-Aminomethyl-2-methyl-4-pyrimidineamine
  • (4-amino-2-methyl-pyrimidin-5-yl)methylamine
  • Grewe DiaMine
  • Thiamine Impurity 16
  • 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE ISO 9001：2015 REACH
  • Thiamine Impurity 48
  • 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE
  • Thiamine /Vitamin B1 Impurity 19
  • Vitamin B1 Impurity 9
  • Diazinon Impurity 6 (Diazoxon)
  • 95-02-3
  • C6H12Cl2N4
  • C6H10N42HCl
  • Bases & Related Reagents
  • Nucleotides
  • Amines
  • Aromatics
  • Enzyme substrates
  • Heterocycles
  • Nucleotides and Nucleosides
  • Heterocycle-Pyrimidine series
  • PYRIMIDINE