Z-TYR-OME

Product Name: Z-TYR-OME
CAS No.: 13512-31-7
Chemical Name: Z-TYR-OME
Synonyms: CBZ-Tyr-OMe;Z-L-TYROSINE METHYL ESTER;Z-TYR-OME;Z-L-Tyr-OMe;Cbz-L-Tyr-OMe;Z-TYROSINE-OME;Z-TYR-OME USP/EP/BP;CBZ-L-TYROSINE METHYL ESTER;Z-L-tyrosine methyl ester99%;N-Cbz-L-tyrosine Methyl ester
CBNumber: CB9759271
Molecular Formula: C18H19NO5
Formula Weight: 329.35
MOL File: 13512-31-7.mol

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Z-TYR-OME Property

Melting point:: 93-97 °C(lit.)
Boiling point:: 528.1±50.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 9.75±0.15(Predicted)
form: Solid
Appearance: White to off-white Solid
optical activity: [α]20/D +48°, c = 1 in chloroform
CAS DataBase Reference: 13512-31-7(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 242850
Product name: Z-L-tyrosine methyl ester 99+%
Packaging: 1g
Price: $156
Updated: 2021/12/16

Chem-Impex

Product number: 06674
Product name: Z-L-tyrosine methyl ester
Purity: ≥ 99% (HPLC)
Packaging: 25G
Price: $62.1
Updated: 2021/12/16

Chem-Impex

Product number: 06674
Product name: Z-L-tyrosinemethylester,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 1G
Price: $13.5
Updated: 2021/12/16

Chem-Impex

Product number: 06674
Product name: Z-L-tyrosine methyl ester
Purity: ≥ 99% (HPLC)
Packaging: 5G
Price: $25.9
Updated: 2021/12/16

Activate Scientific

Product number: AS91167
Product name: N-Cbz-L-tyrosine Methyl Ester
Purity: 98+% ee
Packaging: 25g
Price: $71
Updated: 2021/12/16

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Z-TYR-OME Chemical Properties,Usage,Production

Uses

N-Cbz-L-tyrosine Methyl Ester is used in preparation of optically active Imidazolidione derivatives from N-Benzyloxycarbonyl-tyrosine Ester via Ethylation, reduction and successive treatment with Methanesulfonyl Chloride, Ethylenediamine and Lithium Hydroxide.

Synthesis

3417-91-2

501-53-1

13512-31-7

To the solid L-tyrosine methyl ester hydrochloride (Tyr-OMe-HCl) obtained above, 300 g of ethyl acetate (AcOEt) was added, 100 g of sodium carbonate (Na2CO3) and 50 g of water under stirring. Benzyl chloroformate (Z-Cl) was slowly added dropwise while controlling the pH of the reaction system to 8. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction system was free of L-tyrosine methyl ester hydrochloride (Tyr-OMe-HCl). Subsequently, citric acid was added to acidify the reaction solution to pH=3 and the layers were left to separate. The organic layer was washed to neutrality with brine. To the organic layer 20-50 g of anhydrous sodium sulfate (Na2SO4) was added and stirred for 4 hours for drying. The sodium sulfate (Na2SO4) was removed by filtration and the filtrate was concentrated and transferred to a crystallization kettle. Concentrate the concentrate with hot water until dry, add 200g of petroleum ether (PET), stirring until crystallization is complete. White crystals of N-Benzyloxycarbonyl-L-tyrosine methyl ester (ZL-Tyr-OMe) were obtained by filtration and dried to give 390 g of product with 4% moisture content.

References

[1] Journal of the American Chemical Society, 2004, vol. 126, # 32, p. 10162 - 10173
[2] Croatica Chemica Acta, 2003, vol. 76, # 1, p. 23 - 36
[3] Journal of Organic Chemistry, 1986, vol. 51, # 14, p. 2728 - 2735
[4] Journal of the American Chemical Society, 2004, vol. 126, # 40, p. 12897 - 12906
[5] Patent: CN103833593, 2016, B. Location in patent: Paragraph 0045; 0047

Z-TYR-OME Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-TYR-OME Suppliers

China 111 France 1 Germany 2 India 2 Japan 1 South Korea 1 Switzerland 2 United Kingdom 3 United States 17 Global 140

ChemPep, Inc.

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View Lastest Price from Z-TYR-OME manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Z-TYR-OME 13512-31-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-25

Career Henan Chemical Co

Product: Z-TYR-OME 13512-31-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

Career Henan Chemical Co

Product: Z-TYR-OME 13512-31-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-15

13512-31-7, Z-TYR-OMERelated Search:

N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt Z-TYR(BZL)-OH Z-TYR-NH2 N-CARBOBENZOXY-L-TYROSINE DICYCLOHEXYLAMINE SALT Z-TYR-TYR-OH Z-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE Z-TYR-ONP Z-TYR-OH Z-VAL-OSU Z-VAL-NH2 Z-VAL-PHE-OME Z-TLE-OH DCHA Z-TRP-OME Z-TYR(TBU)-OSU N-Cbz-L-Threonine Cbz-L-Threonine benzyl ester Z-THR-OSU N-Carbobenzyloxy-L-threonine methyl ester

N-CARBOBENZOXY-L-TYROSINE METHYL ESTER

N-ALPHA-CARBOBENZOXY-L-TYROSINE METHYL ESTER

Z-L-TYROSINE METHYL ESTER

Z-TYR-OME

Z-TYROSINE-OME

CBZ-L-TYROSINE METHYL ESTER

(S)-methyl 2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoate

N-Benzyloxycarbonyl-L-tyrosine Methyl ester

N-Cbz-L-tyrosine Methyl ester

CBZ-Tyr-OMe

N-(Benzyloxycarbonyl)tyrosine methyl ester

Cbz-L-Tyr-OMe

Z-L-Tyr-OMe

Z-L-tyrosine methyl ester99%

L-Tyrosine,N-[(phenylmethoxy)carbonyl]-, methyl ester

methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate

methyl(2S)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoate

Z-TYR-OME USP/EP/BP

N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester

Linaclotide Impurity 14 (Z-Tyr-OMe)

Tyrosine, N-carboxy-, N-benzyl methyl ester, L- (8CI)

13512-31-7

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Tyrosine

AMINOACIDS DERIVATIVES

Z-Amino Acids and Derivatives

Z-Amino acid series

Amino Acid Derivatives

Peptide Synthesis

Tyrosine