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Z-VAL-NH2

Product Name
Z-VAL-NH2
CAS No.
13139-28-1
Chemical Name
Z-VAL-NH2
Synonyms
Z-VAL-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
CBNumber
CB4438832
Molecular Formula
C13H18N2O3
Formula Weight
250.29
MOL File
13139-28-1.mol
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Z-VAL-NH2 Property

Boiling point:
452.2±38.0 °C(Predicted)
Density 
1.144±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
Solid
pka
11.09±0.46(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
V963035
Product name
Z-Val-NH2
Packaging
50mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
292018
Product name
Z-L-valine amide
Packaging
2g
Price
$347
Updated
2021/12/16
Chem-Impex
Product number
12362
Product name
Z-L-valineamide,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$34.83
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-1-SD
Product name
Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide
Packaging
500mg
Price
$104
Updated
2021/12/16
Chem-Impex
Product number
12362
Product name
Z-L-valineamide,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$110.1
Updated
2021/12/16
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Z-VAL-NH2 Chemical Properties,Usage,Production

Synthesis

1149-26-4

13139-28-1

The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365

Z-VAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-VAL-NH2 Suppliers

China 59 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 8 Global 73
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Nanjing Derno Pharmaceutical Technology Co., Ltd.
Tel
025-86957866 13952093866
Fax
025-68661287
Email
sales@dernopharm.com
Country
China
ProdList
932
Advantage
58
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from Z-VAL-NH2 manufacturers

Career Henan Chemical Co
Product
Z-VAL-NH2 13139-28-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99.99%
Supply Ability
1kg-10MT
Release date
2019-05-24

13139-28-1, Z-VAL-NH2Related Search:

Z-VAL-PHE-OH Z-VAL-OSU Z-VAL-GLY-OH Z-VAL-ONP Z-VAL-PRO-OH N-Carbobenzyloxy-L-valine Z-TYR-OH Z-TLE-OH DCHA Z-TRP-OME Z-TYR(TBU)-OSU Z-TYR-ONP Z-TYR-OME Z-L-Valine NCA Z-VAL-OET Z-VAL-PHE-OME Z-VAL-ALA-OH Z-VAL-SER-OH CBZ-L-VALINE METHYL ESTER

  • N-Benzyloxycarbonyl-L-valinamide
  • N-Benzyloxycarbonylvaline amide
  • Benzyloxycarbonyl-L-valinamide
  • (S)-N-Benzoyloxycarbonyl valinamide
  • Z-L-Val-NH2
  • N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE
  • Z-L-VALINE AMIDE
  • Z-VAL-NH2
  • CBZ-L-VALINE AMIDE
  • (S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate
  • CBZ-Val-NH2
  • (S)-N-(Benzyloxycarbonyl)valinamide
  • Benzyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate
  • benzyl N-[(1S)-1-carbamoyl-2-methylpropyl]carbamate
  • N-Cbz-L-valinamide
  • Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, phenylmethyl ester
  • benzylN-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate
  • Z-VAL-NH2 USP/EP/BP
  • Cbz-L-Val-NH2
  • 13139-28-1