Nafamostat mesylate

Product Name: Nafamostat mesylate
CAS No.: 82956-11-4
Chemical Name: Nafamostat mesylate
Synonyms: FUTHAN;FUT-175;CS-128;Coahibitor;nafamstatmesilate;Nafamostat mesila;Nafomastatmesilate;Nafamstat mesylate;Nafmostat mesylate;NAFAMOSTAT MESYLATE
CBNumber: CB9764794
Molecular Formula: C21H25N5O8S2
Formula Weight: 539.58
MOL File: 82956-11-4.mol

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Nafamostat mesylate Property

Melting point:: 259-261°C
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Water (up to 25 mg/ml).
form: powder
color: white to beige
Merck: 14,6350
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months.
InChI: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChIKey: SRXKIZXIRHMPFW-UHFFFAOYSA-N
SMILES: CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1
CAS DataBase Reference: 82956-11-4(CAS DataBase Reference)

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Safety

RIDADR: 3077
WGK Germany: nwg
RTECS: DG2736000
HS Code: 29252900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N0289
Product name: Nafamostat mesylate
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $156
Updated: 2024/03/01

Sigma-Aldrich

Product number: N0289
Product name: Nafamostat mesylate
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $613
Updated: 2024/03/01

TCI Chemical

Product number: N0959
Product name: Nafamostat Mesylate
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: N0959
Product name: Nafamostat Mesylate
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 14837
Product name: Nafamostat (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

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Nafamostat mesylate Chemical Properties,Usage,Production

Description

Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.

Chemical Properties

Tan to pale orange solid

Originator

Torii (Japan)

Uses

A non-peptide proteaseinhibitor.

Uses

Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma

brand name

FUTHAN

Biological Activity

Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Biochem/physiol Actions

Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.

Synthesis

By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.

storage

Store at +4°C

References

1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80

Nafamostat mesylate Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Nafamostat mesylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Nafamostat mesylate 82956-11-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98.5～101.5%
Supply Ability: 10kg/month
Release date: 2021-06-17

Hebei Dangtong Import and export Co LTD

Product: Nafamostat mesylate 82956-11-4
Price: US $100.00-9800.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-09-10

airuikechemical co., ltd.

Product: nafamostat mesilate 82956-11-4
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-10

82956-11-4, Nafamostat mesylateRelated Search:

Denatonium Benzoate Anhydrous Pimecrolimus NAFAMOSTAT MESYLATE Betahistine mesylate Methyl benzoate p-Toluic acid 3-(Trifluoromethyl)benzoic acid Sodium benzoate 1-(1-NAPHTHYL)-2-THIOUREA m-Toluic acid Benzyl benzoate Methyl 4-methylbenzoate Emamectin benzoate Methyl 4-(bromomethyl)benzoate o-Toluic acid WIN 55,212-2 MESYLATE Gabexate mesylate Lignin Sulfonate

4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl

6-carbaMiMidoylnaphthalen-2-yl 4-guanidinobenzoate diMethanesulfonate

[amino-[6-[[4-(diaminomethyleneazaniumyl)phenyl]-oxomethoxy]-2-naphthyl]methylene]ammonium

[amino-[6-[4-(diaminomethyleneazaniumyl)benzoyl]oxy-2-naphthyl]methylene]ammonium

[amino-[6-[4-(diaminomethylideneazaniumyl)benzoyl]oxynaphthalen-2-yl]methylidene]azanium

[amino-[6-[4-(diaminomethylideneazaniumyl)phenyl]carbonyloxynaphthalen-2-yl]methylidene]azanium

Nafamostat mesylate, >=98%

5-methyl-1-{6-[(7-oxo-7h-furo[3,2-g]chromen-9-yl)oxy]hexyl}pyrimidine-2,4(1h,3h)-dione

Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate

ester,dimethanesulfonate

nafamstatmesilate

NAFAMOSTAT MESYLATE

FUT-175

FUTHAN

6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE

6-amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate

6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE

FUT-175,6-Amidino-2-naphthyl-4-guanidinoenzoate,mesylate

Nafomastatmesilate

FUT-175, 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate

4-Guanidinobenzoic acid 6-amidino-2-naphtyl·2(methanesulfonic acid)

Nafamstat mesylate

4-[(Aminoiminomethyl)amino]benzoicacid6-(aminoiminomethyl)-2-naphthalenylesterdimethanesulfonate

NafaMostat Mesilate, NafaMostat Mesylate

Nafamostat mesilate C21H25N5O8S2 high quality Casnumber： 82956-11-4

Nafamostat mesylate, 98%, broad spectrum, potent protease inhibitor

NafaMostat Mesylate(FUT-175)

Nafamostat mesila

Nafamostat mesylate Manufacturer/High quality/Best price/In stock CAS NO.82956-11-4

CS-128

Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)

Coahibitor

COAHIBITOR;FUT-175;FUTHAN

6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate

Nafamostat Mesylate &gt

Nafmostat mesylate

4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Bis(methanesulfonate)

6-Amidino-2-naphthyl 4-Guanidinobenzoate Bis(methanesulfonate)

Nafamostat Mesylate (10mM in DMSO)

Supply Nafamostat Mesylate CAS: 82956-11-4

Nafamostat Mesylate for Treatment Pancreatitis CAS No.:?82956-11-4

[13C6]-Nafamostat mesylate

Naphthalimostat methanesulfonate

Nafamostat mesilate (FUT-175)

Naphtholimus mesylate

Nafamostat Mesylate CRS

Nafamostate Mesylate

6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate methanesulfonate

82956-11-4

C21H25N5O8S2

C19H17N5O22C4O3S

C19H17N5O22CH4O3SC21H25N5O8S2

C19H17N5O22CH3SO3H

C19H17N5O22CH4O3S

Inhibitors

Aromatics

Intermediates & Fine Chemicals