Siltuximab
- Product Name
- Siltuximab
- CAS No.
- 541502-14-1
- Chemical Name
- Siltuximab
- Synonyms
- CNTO-328;Siltuximab;Siltuximab (anti-IL-6);Research Grade Siltuximab;Research Grade Siltuximab(DHC15801)
- CBNumber
- CB98080799
- Formula Weight
- 0
- MOL File
- Mol file
Siltuximab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Siltuximab Chemical Properties,Usage,Production
Uses
Siltuximab it is used for cancer treatment using anti-ICOS antibody if patient has low peripheral T cell receptor clonality.
Clinical Use
Chimeric (human-murine) immunoglobulin G1κ
(IgG1κ) monoclonal antibody:
Treatment of multicentric Castleman’s disease
(MCD)
in vivo
Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model[1].
Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model[4].
| Animal Model: | Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; 10 mg/kg; 3 times per week |
| Result: | Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells. Repressed PY-STAT3 levels in H1650 cells. Inhibited the growth of tumors with H322 and CAF cells. Inhibited the growth of tumors with H1650 and CAF cells. |
| Animal Model: | Female NOD-SCID mice with MCF-7 tumor[4] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks |
| Result: | Blocked MCF-7 engraftment, induced regressions in 90% of tumors. |
Drug interactions
Potentially hazardous interactions with other drugs
Live vaccines: risk of generalised infections - avoid.
Ciclosporin and tacrolimus: monitor levels on
initiation and discontinuation of siltuximab as it may
reduce the activity of CYP450.
Metabolism
As siltuximab is a monoclonal antibody, the expected consequence of metabolism is proteolytic degradation to small peptides and individual amino acids, and receptormediated clearance.
Siltuximab Preparation Products And Raw materials
Raw materials
Preparation Products
Siltuximab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58