Orilanolimab
- Product Name
- Orilanolimab
- CAS No.
- 2066544-85-0
- Chemical Name
- Orilanolimab
- Synonyms
- Orilanolimab;Research Grade Orilanolimab;Research Grade Orilanolimab (DHF14601)
- CBNumber
- CB98081105
- Formula Weight
- 0
- MOL File
- Mol file
Orilanolimab Property
- form
- Liquid
- color
- Colorless to light yellow
Orilanolimab Chemical Properties,Usage,Production
Uses
Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity[1][2].
in vivo
Orilanolimab (20 mg/kg; i.v.) significantly reduces the plasma concentration of HuLys11 in mouse model[1].
Orilanolimab (10-100 mg/kg; i.v.; once per 5 weeks) causes dose-dependent and specific reduction of total circulating levels of IgG cynomolgus monkeys[1].
References
[1] Blumberg LJ, et al. Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. Sci Adv. 2019 Dec 18;5(12):eaax9586. DOI:10.1126/sciadv.aax9586
[2] Blumberg L, et al. SYNT001: a humanized IgG4 monoclonal antibody that disrupts the interaction of FcRn and IgG for the treatment of IgG-mediated autoimmune diseases[J]. Blood, 2017, 130: 3483.
Orilanolimab Preparation Products And Raw materials
Raw materials
Preparation Products
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