ChemicalBook > CAS DataBase List > Tidutamab
Tidutamab
- Product Name
- Tidutamab
- CAS No.
- 2148354-90-7
- Chemical Name
- Tidutamab
- Synonyms
- Tidutamab;Research Grade Tidutamab;Research Grade Tidutamab (DHD91601)
- CBNumber
- CB98081145
- Formula Weight
- 0
- MOL File
- Mol file
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Tidutamab Chemical Properties,Usage,Production
Uses
Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC)[1].
in vivo
Tidutamab (XmAb-18087; 3 mg/kg; i.p.; single dose) stimulates human T cell killing of SSTR2+ A549 lung carcinoma tumors in NSG mice[1].
| Animal Model: | NSG mice[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection; single dose |
| Result: | lnduced anti-tumor activity in human PBMC-engrafted NSG mice. |
References
[1] Hyung LS, et, al. Anti-SSTR2 × anti-CD3 bispecific antibody induces potent killing of human tumor cells?in vitro?and in mice, and stimulates target-dependent T cell activation in monkeys: A potential immunotherapy for neuroendocrine tumors. Cancer Res?(2017) 77 (13_Supplement): 3633.
Tidutamab Preparation Products And Raw materials
Raw materials
Preparation Products
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Tidutamab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
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