Adintrevimab

Product Name: Adintrevimab
CAS No.: 2516243-54-0
Chemical Name: Adintrevimab
Synonyms: Adintrevimab;Research Grade Adintrevimab;Research Grade Adintrevimab (DVV00315)
CBNumber: CB810617124
Formula Weight: 0
MOL File: Mol file

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Adintrevimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Adintrevimab Chemical Properties,Usage,Production

Uses

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].

in vivo

Adintrevimab (9.25, 55, 333, or 2,000?μg; i.p.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner^[1].
Adintrevimab (5-25?mg/kg; i.v.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner^[1].

Animal Model:	Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020^[1].
Dosage:	9.25, 55, 333, or 2,000?μg (average range: 0.1 to 20?mg/kg)
Administration:	Intraperitoneal injection; single dose
Result:	Showed significant reduction in lung viral load and virus-induced lung pathology.

Animal Model:	Rhesus macaques (5.6-8.8?years old; 6 females [4.4-6.3?kg] and 6 males [6.1-8.5?kg]) infected with SARS-CoV-2/WA1/2020^[1].
Dosage:	5?mg/kg, 25?mg/kg
Administration:	Intravenous injection; single dose
Result:	Reduced pulmonary inflammation.

References

[1] Elizabeth E Zumbrun, et al. Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19. Antimicrob Agents Chemother. 2022 Dec 15;e0135322. DOI:10.1128/aac.01353-22

Adintrevimab Preparation Products And Raw materials

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Preparation Products

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Adintrevimab

Research Grade Adintrevimab (DVV00315)

Research Grade Adintrevimab

2516243-54-0