Hydroxysafflor yellow A
- Product Name
- Hydroxysafflor yellow A
- CAS No.
- 78281-02-4
- Chemical Name
- Hydroxysafflor yellow A
- Synonyms
- HSYA;SAFFLOMIN A;Hydroxysafflor yellow;Hydroxysafflor yellow A;Hydroxysafflor yellow A-RM;Hydroxy safflower yellow pigment A;Hydroxylsafflower yellow pigment A;Hydroxysafflor yellow A,Safflomin A;Hydroxysafflor yellow A, 10 mM in DMSO;Hydroxysafflor yellow A,SaffloMin A,HSYA
- CBNumber
- CB9843710
- Molecular Formula
- C27H32O16
- Formula Weight
- 612.54
- MOL File
- 78281-02-4.mol
Hydroxysafflor yellow A Property
- Melting point:
- 184-186 °C
- Boiling point:
- 1015.8±65.0 °C(Predicted)
- Density
- 1.851±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
- pka
- 4.50±1.00(Predicted)
- form
- powder
- color
- Yellow-orange
- InChIKey
- LIPJRCGLQNIXGO-KGDWUUGINA-N
- LogP
- 1.688 (est)
Safety
- Safety Statements
- 24/25
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 300905
- Product name
- Safflomin A
- Packaging
- 20mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- orb259580
- Product name
- Safflomin A
- Purity
- 98%
- Packaging
- 20mg
- Price
- $408
- Updated
- 2021/12/16
- Product number
- 097908
- Product name
- Hydroxysafflor yellow A
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $431
- Updated
- 2021/12/16
- Product number
- OH08134
- Product name
- Hydroxysafflor yellow A
- Packaging
- 10mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- orb259580
- Product name
- Safflomin A
- Purity
- 98%
- Packaging
- 100mg
- Price
- $472.6
- Updated
- 2021/12/16
Hydroxysafflor yellow A Chemical Properties,Usage,Production
Chemical Properties
Derived from the dried flowers of Carthamus tinctorius L.
Uses
Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease[1][2][3][4][5][6].
Definition
ChEBI: Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol.
Biological Activity
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities. It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 μM.
in vivo
Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats. It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral is chemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.
References
[1] Yang G, et al. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302. PMID:26131104
[2] Zhu HJ, et al. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Oct;67(5):885-92. DOI:10.1007/s10616-014-9783-3
[3] Jin M, et al. Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury. Chin J Integr Med. 2016 Jan;22(1):36-41. DOI:10.1007/s11655-015-1976-x
[4] He Y, et al. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78. DOI:10.1007/s13105-015-0382-3
[5] Jin M, Xue et al. Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats. Chin J Integr Med. 2019 Oct;25(10):750-756. DOI:10.1007/s11655-018-2577-2
[6] Wu N, et al. Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer. Biomed Pharmacother. 2021 Apr;136:111227. DOI:10.1016/j.biopha.2021.111227
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Raw materials
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View Lastest Price from Hydroxysafflor yellow A manufacturers
- Product
- Hydroxysafflor yellow A 78281-02-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-12
- Product
- SAFFLOMIN A 78281-02-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-12