ChemicalBook > CAS DataBase List > 3-Hydroxyphenylacetylene

3-Hydroxyphenylacetylene

Product Name
3-Hydroxyphenylacetylene
CAS No.
10401-11-3
Chemical Name
3-Hydroxyphenylacetylene
Synonyms
3-ETHYNYLPHENOL;4-ETHYNYL-PHENOL;Phenol, 3-ethynyl-;TIMTEC-BB SBB005886;3-HYDROXYPHENYLACETYLENE;Phenol, 3-ethynyl- (9CI);M-HYDROXYPHENYLACETYLENE;3-HYDROXYPHENYLACETYLENE, 95+%;3-Hydroxyphenylacetylene >=95.0%;3-HYDROXYPHENYLACETYLENE (3-Ethynylphenol)
CBNumber
CB9852635
Molecular Formula
C8H6O
Formula Weight
118.13
MOL File
10401-11-3.mol
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3-Hydroxyphenylacetylene Property

Melting point:
64-66 °C
Boiling point:
75°C 3mm
Density 
1.083 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5840(lit.)
Flash point:
218 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Miscible with dimethylformamide.
pka
9.30±0.10(Predicted)
form 
Crystalline Powder
color 
White to pale yellow
BRN 
2076613
InChI
InChI=1S/C8H6O/c1-2-7-4-3-5-8(9)6-7/h1,3-6,9H
InChIKey
AODMJIOEGCBUQL-UHFFFAOYSA-N
SMILES
C1(O)=CC=CC(C#C)=C1
CAS DataBase Reference
10401-11-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41-52/53
Safety Statements 
26-37/39
RIDADR 
2810
WGK Germany 
2
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29071990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
632023
Product name
3-Hydroxyphenylacetylene
Purity
≥95.0%
Packaging
1g
Price
$66.6
Updated
2025/07/31
Sigma-Aldrich
Product number
632023
Product name
3-Hydroxyphenylacetylene
Purity
≥95.0%
Packaging
5g
Price
$271
Updated
2025/07/31
TCI Chemical
Product number
E1421
Product name
3-Ethynylphenol
Purity
min. 98.0 %
Packaging
1G
Price
$277
Updated
2025/07/31
GFS CHEMICALS
Product number
81992
Product name
3-ETHYNYLPHENOL,95%
Packaging
10g
Price
$777.23
Updated
2021/12/16
TRC
Product number
E938110
Product name
3-Ethynylphenol
Packaging
100mg
Price
$65
Updated
2021/12/16
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3-Hydroxyphenylacetylene Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Uses

3-Hydroxyphenylacetylene is used as a fluorogenic and chromogenic probe for bacterial enzymes.

Synthesis

388061-72-1

10401-11-3

The general procedure for the synthesis of 3-hydroxyphenylacetylene from (3-hydroxyphenylalkynyl)trimethylsilane was as follows: (3-hydroxyphenylalkynyl)trimethylsilane was dissolved in a mixed solvent of THF (6 mL) and MeOH (6 mL), followed by the addition of 10% aqueous KOH solution (6 mL). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction mixture was neutralized with 1N HCl solution and the solvent was subsequently removed by rotary evaporation. The aqueous phase was extracted with CH2Cl2 and the organic phase was dried with anhydrous Na2SO4. Finally, purification by column chromatography (eluent: n-hexane/acetone, 5:1, v/v) afforded 3-hydroxyphenylacetylene (162.8 mg, 70% yield), the product was a yellow oil.

References

[1] Patent: US2009/68242, 2009, A1. Location in patent: Page/Page column 7
[2] Organic Letters, 2014, vol. 16, # 24, p. 6302 - 6305

3-Hydroxyphenylacetylene Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Hydroxyphenylacetylene Suppliers

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View Lastest Price from 3-Hydroxyphenylacetylene manufacturers

Career Henan Chemical Co
Product
3-Hydroxyphenylacetylene 10401-11-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

10401-11-3, 3-HydroxyphenylacetyleneRelated Search:

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