Propyl chloroformate

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Propyl chloroformate

Product Name: Propyl chloroformate
CAS No.: 109-61-5
Chemical Name: Propyl chloroformate
Synonyms: NPCF;propyl carbonochloridate;PROPYL CHLOROCARBONATE;Propyl chloroforMat;PROPYL CHLOROFORMATE;Proply chloroformate;N-PROPYL CHLOROFORMATE;Chloride propyl forMate;Propyl chloridocarbonate;n-Propyl chlorocarbonate
CBNumber: CB9852781
Molecular Formula: C4H7ClO2
Formula Weight: 122.55
MOL File: 109-61-5.mol

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Propyl chloroformate Property

Boiling point:: 105-106 °C(lit.)
Density: 1.09 g/mL at 25 °C(lit.)
vapor pressure: 0.87 psi ( 20 °C)
refractive index: n20/D 1.404(lit.)
Flash point:: 84 °F
storage temp.: 2-8°C
solubility: benzene: miscible(lit.)
form: Oil
color: Colourless
Specific Gravity: 1.09
Merck: 13,7940
Dielectric constant: 11.2（20℃）
Stability:: Volatile
InChIKey: QQKDTTWZXHEGAQ-UHFFFAOYSA-N
LogP: 1.385 (est)
CAS DataBase Reference: 109-61-5(CAS DataBase Reference)
NIST Chemistry Reference: n-Propylchloroformate(109-61-5)
EPA Substance Registry System: Propyl chloroformate (109-61-5)

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Safety

Hazard Codes: T,F
Risk Statements: 10-23-34-22-11
Safety Statements: 26-36-45-16
RIDADR: UN 2740 6.1/PG 1
WGK Germany: 1
RTECS: LQ6830000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29151300
Hazardous Substances Data: 109-61-5(Hazardous Substances Data)
Toxicity: mouse,LC50,inhalation,319ppm/1H (319ppm),"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 4, Pg. 758, 1978.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 249467
Product name: Propyl chloroformate
Purity: 98%
Packaging: 25g
Price: $45.3
Updated: 2023/01/07

Sigma-Aldrich

Product number: 249467
Product name: Propyl chloroformate
Purity: 98%
Packaging: 100g
Price: $129
Updated: 2023/01/07

TRC

Product number: P835120
Product name: Propyl chloroformate
Packaging: 5g
Price: $110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026913
Product name: N-PROPYL CHLOROFORMATE
Purity: 95.00%
Packaging: 25G
Price: $1129.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026913
Product name: N-PROPYL CHLOROFORMATE
Purity: 95.00%
Packaging: 100G
Price: $2539.13
Updated: 2021/12/16

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Propyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

Propyl Chloroformate (PCF) is a colorless to yellow liquid, with a pungent odor. It reacts with water and spontaneous decomposes. It is miscible with benzene and ether.

Uses

Propyl Chloroformate is used as a dramatizing agent for the determination of morphine, codeine and 6-acetyl morphine in urine and blood using direct aqueous derivatization.

Application

Propyl chloroformate has been used:
as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry
in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate
N-propyl chloroformate is an intermediate of the fungicide propamocarb.

Preparation

Synthesis of Propyl chloroformate: Add n-propanol to the phosgene-passing kettle, start stirring, and then pass phosgene through the phosgene flowmeter. The phosgene-passing temperature is about 30 °C, and continue to pass the phosgene for several hours. When the end point is approached, sample and analyze, and stop when the standard is reached. Pass phosgene, cool, and then pass nitrogen to drive away phosgene and hydrogen chloride, destroy phosgene, and sample and analyze it as a product.
Reaction equation: CH3CH2CH2OH+COCl2→ClCOOCH2CH2CH3

Production Methods

Prepared by the reaction of liquid anhydrous n-propyl alcohol with molar excess of dry, chlorine-free phosgene at low temperature.

General Description

N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.

Reactivity Profile

Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Strongly irritating to eyes and mucous membranes. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin.

Fire Hazard

When heated to decomposition, Propyl chloroformate emits toxic fumes of chlorine containing compounds. Propyl chloroformate is a flammable/combustible material; Propyl chloroformate may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat or fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Runoff from fire control or dilution water may cause pollution. Gradually decomposed by water and alcohol. Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air.

Flammability and Explosibility

Flammable

Safety Profile

Poison by skin contact. Moderately toxic by ingestion and inhalation. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame, can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-. Used as a reactive intermediate to polymerization initiators.

Potential Exposure

Propyl chloroformate is used in organic synthesis; as an intermediate for polymerization initiators; may have been used as a military poison gas.

Shipping

UN2740 n-Propyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material. Inhalation Hazard Zone B

Incompatibilities

Propyl chloroformate forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water and alcohols. Reaction with water forms heat and hydrochloric acid. Attacks some metals and coating in the presence of moisture.

Propyl chloroformate Preparation Products And Raw materials

Raw materials

Flow Cell Hydrochloric acid

Preparation Products

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View Lastest Price from Propyl chloroformate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Propyl chloroformate 109-61-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Propyl chloroformate 109-61-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Propyl chloroformate 109-61-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

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